Neonatal Group B Streptococcus infection at a single center in Al-Madinah Al-Munawarah, Saudi Arabia

Article Figures & Data

Table 1

- Study participants’ demographics.

Characteristics	n (%)
Sample size	64 (100)
Gender
Female	30 (46.9)
Male	34 (53.1)
Gestational age
Preterm	10 (15.6)
Term	54 (84.4)
Mode of delivery
Vaginal	46 (71.9)
Cesarean section	18 (28.1)
Birthweight, mean±SD	2.4±0.73 kg
2.1-3.5 kg	35 (54.6)
1.2 kg - 600 g	29 (45.4)
Age at diagnosis, mean±SD	10±12.4 days
Temperature (fever)
Yes (>36.5)	10 (15.6)
No (≤36.5)	54 (84.4)
CBC results:
RBC (5.1-5.3 million/mm³)	4.9±1.5 million/mm³
WBC (9,000-30,000/mm³)^*	10,000±1000/mm³
PLT (150×10³ - 450×10³/mcL)	300×10³±100.6/mcL
Cardiorespiratory instability
Ventilated	20 (31.3)
Shocked	15 (23.4)
No need	29 (45.3)
Participants categories
EOD	34 (53.1)
LOD	30 (46.9)

Values are presented as numbers and precentages (%) or mean ± standard deviation (SD).

RBC: red blood cells, WBC: white blood cells, PLT: platelets, EOD: early-onset disease at 0-6 days, LOD: late-onset disease at 7-90 days

↵* Approximately 7.8% of infected neonatal had leukopenia (WBCs of <3,000/mm³) wherase, 59 (92.2%) pateintes had normal WBCs level.

Table 2

- Group B Streptococcus screening and the pregnancy record of the mother.

Characteristics	n (%)
Total sample size	64 (100)
Screens for GBS
Positive	4 (6.2)
Negative	4 (6.2)
None	56 (87.5)
Predisposing risk factors among the mothers of newborns (n=25)
Sample size	25 (39.1)
Age (years)	20±5.4 years
Gestational age
Preterm	10 (40.0)
Term	15 (60.0)
Mode of delivery
Vaginal	15 (60.0)
Cesarean section	10 (40.0)
Fever at the time of labor	11 (44.0)
Prolonged premature rupture of the membrane	9 (36.0)
Screens for GBS in 25 mothers
Positive	4 (16.0)
Negative	4 (16.0)
None	17 (68.0)

Values are presented as numbers and precentages or mean ± standard deviation (SD). GBS: Group B Streptococcus

Table 3

- The associations between risk factors for Group B Streptococcus infection and the onset of Group B Streptococcus.

Characteristics	Total	EOD	LOD
Sample size	64 (100)	34 (53.1)	30 (46.9)
Gender
Female	30 (46.9)	15 (44.1)	15 (50.0)
Male	34 (53.1)	19 (55.9)	15 (50.0)
Gestational age
Preterm	10 (15.6)	7 (20.6)	3 (10.0)^*
Term	54 (84.4)	27 (79.4)	27 (90.0)
Mode of delivery
Vaginal	46 (71.9)	24 (70.6)	22 (73.3)
Cesarean section	18 (28.1)	7 (13.3)	8 (26.7)
Prolonged rupture of membranes of >18 hours	11 (17.2)	9 (26.5)^*	2 (6.0)
Intrapartum fever	14 (21.9)	10 (29.4)^*	4 (13.3)
Birthweight
2.1-3.5 kg	35 (54.6)	13 (38.2)	22 (73.3)
1.2 kg - 600 g	29 (45.4)	21 (61.8)^*	8 (26.7)
Age at diagnosis, mean±SD	10±12.4 days	5±1.4 days	9±2.2 days
Diagnosis
Sepsis	50 (78.1)	32 (94.1)^*	18 (60.0)
Meningitis	10 (15.6)	1 (2.9)	9 (30.0)^*
Pneumonia	4 (6.3)	1 (2.9)	3 (10.0)
GBS screening (for mothers)
Yes	8 (12.5)	3 (8.8)	5 (16.7)
No	56 (87.5)	31 (91.2)^*	25 (83.3)
Outcomes
Alive	57 (89.1)	32 (94.1)	25 (83.3)
Dead	7 (10.9)	2 (5.9)	5 (16.7)^*

Values are presented as numbers and precentages or mean ± standard deviation (SD).

EOD: early-onset disease at 0-6 days, LOD: late-onset disease at 7-90 days, GBS: Group B Streptococcus