Skip to main content

Main menu

  • Home
  • Content
    • Latest
    • Archive
    • home
  • Info for
    • Authors
    • Reviewers
    • Subscribers
    • Institutions
    • Advertisers
    • Join SMJ
  • About Us
    • About Us
    • Editorial Office
    • Editorial Board
  • More
    • Advertising
    • Alerts
    • Feedback
    • Folders
    • Help
  • Other Publications
    • NeuroSciences Journal

User menu

  • My alerts
  • Log in

Search

  • Advanced search
Saudi Medical Journal
  • Other Publications
    • NeuroSciences Journal
  • My alerts
  • Log in
Saudi Medical Journal

Advanced Search

  • Home
  • Content
    • Latest
    • Archive
    • home
  • Info for
    • Authors
    • Reviewers
    • Subscribers
    • Institutions
    • Advertisers
    • Join SMJ
  • About Us
    • About Us
    • Editorial Office
    • Editorial Board
  • More
    • Advertising
    • Alerts
    • Feedback
    • Folders
    • Help
  • Follow psmmc on Twitter
  • Visit psmmc on Facebook
  • RSS
In BriefIn this issue
Open Access

In this issueReview ArticleOriginal ArticleCase Report

Saudi Medical Journal August 2024, 45 (8) 757;
  • Article
  • Figures & Data
  • eLetters
  • Info & Metrics
  • References
  • PDF
Loading

Review Article

The protagonist of contemporary and emerging nanotechnology-based theranostics and therapeutic approaches in reshaping intensive care unit

Xie & Chen explore the current impact of nanotechnology, with a particular focus on bacterial infections and severe acute respiratory syndrome coronavirus 2, which significantly strain healthcare systems, and then discuss how nanotechnology can enhance existing treatment methodologies. They have highlight the effectiveness of the nanotechnology-based bactericide Bio-Kil in reducing bacterial counts in an intensive care unit. The aim is to educate healthcare professionals on the existing role and prospects of nanotechnology in addressing prevalent infectious diseases. They concluded that innovative methods of analysis and artificial devices are always needed to integrate nanotechnology-based procedures into clinical practice. Various efforts are also necessary to equip chronic injury treatment in terms of area and targeted effectiveness to avoid unwanted occurrences and interventions that might hamper the biological behavior of nanotechnologies in the human body.

Figure
  • Download figure
  • Open in new tab
  • Download powerpoint

Future potential for nanotechnology advancement in emergency medicine investigation and practice in the next years.

see page 759

Original Article

Identification of effective diagnostic genes and immune cell infiltration characteristics in small cell lung cancer by integrating bioinformatics analysis and machine learning algorithms

Chen et al identify potential diagnostic markers for small cell lung cancer (SCLC) and investigate the correlation with immune cell infiltration. Machine learning (ML) is used to identify candidate diagnostic genes for SCLC. The area under the receiver operating characteristic curves is applied to assess diagnostic efficacy. Immune cell infiltration analyses are carried out. The gene ontology analysis show that differentially expressed genes (DEGs) are enriched in 455 functional annotations, some of which are associated with immunity. The kyoto encyclopedia of genes and genomes analysis reveal that there are 9 signaling pathways enriched. The disease ontology analysis indicate that DEGs are related to 116 diseases. They concluded that this study identified 2 diagnostic genes, ZWINT and NRCAM, that were related to immune cell infiltration by integrating bioinformatics analysis and ML algorithms. These genes could serve as potential diagnostic biomarkers and provide possible molecular targets for immunotherapy in SCLC.

Figure
  • Download figure
  • Open in new tab
  • Download powerpoint

Least absolute shrinkage and selection operator regression plot (the X-axis is logλ, and the Y-axis is the cross-validation error).

see page 771

Inflammatory markers in systemic immune-inflammatory index and inflammatory response index to predict early pregnancy loss

Çallıoğlu et al uncover the predictive value of systemic immune-inflammatory index and systemic inflammatory response index (SIRI) on early pregnancy loss. A total of 535 individuals are enrolled in this retrospective analysis. The early pregnancy losses (EPL) group include patients between 18-35 years old who experience EPL.The EPL group have significantly lower plateletcrit (p=0.04), platelet distribution width (p<0.0001), and red cell distribution width (p<0.0001) and higher monocyte (p<0.0001) and SIRI (p<0.0001) values than the control group. They concluded that this study provides compelling evidence that various inflammatory pathways may significantly contribute to EPL pathogenesis. Moreover, our findings suggest that SIRI could be a more effective marker in predicting EPL in an ongoing pregnancy, thereby potentially revolutionizing early pregnancy loss diagnostics.

Figure
  • Download figure
  • Open in new tab
  • Download powerpoint

Receiver operating characteristic curves for comparisons.

see page 808

Case Report

Obstructive uropathy in STAT 3 hyper immunoglobulin E syndrome. A 5 year old Middle Eastern boy

Bukhari & Alsaidalani present a 5-year-old Middle Eastern boy with symptoms suggestive of obstructive uropathy secondary to multiple large pelviabdominal abscesses and acute kidney injury with hyperkalemia that necessitated admission to the intensive care unit. Upon further investigation, the patient’s genetic test demonstrated a heterozygous missense variant in the STAT3 gene. The patient completely recovered and did not require further admission after initiating prophylactic antibiotics. Although deep-seated infections are uncommon in STAT3 hyper IgE syndrome, skin and lung infections are most commonly observed. Multiple deep collections can occur and require prompt intervention and aggressive treatment. They concluded that an early referral to a clinical immunologist, especially with inborn errors of immunity are suspected, this leads to the early diagnosis of this syndrome, and early intervention.

Figure
  • Download figure
  • Open in new tab
  • Download powerpoint

Coronal reformats showing right upper lobe pneumatocele.

see page 851

  • Copyright: © Saudi Medical Journal

This is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work.

PreviousNext
Back to top

In this issue

Saudi Medical Journal: 45 (8)
Saudi Medical Journal
Vol. 45, Issue 8
1 Aug 2024
  • Table of Contents
  • Cover (PDF)
  • Index by author
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on Saudi Medical Journal.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
In this issueReview ArticleOriginal ArticleCase Report
(Your Name) has sent you a message from Saudi Medical Journal
(Your Name) thought you would like to see the Saudi Medical Journal web site.
Citation Tools
In this issueReview ArticleOriginal ArticleCase Report
Saudi Medical Journal Aug 2024, 45 (8) 757;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
In this issueReview ArticleOriginal ArticleCase Report
Saudi Medical Journal Aug 2024, 45 (8) 757;
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Bookmark this article

Jump to section

  • Article
  • Figures & Data
  • eLetters
  • References
  • Info & Metrics
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • No citing articles found.
  • Google Scholar

More in this TOC Section

  • In this issueOriginal ArticleSystematic ReviewsScoping Review
  • In this issueSystematic ReviewOriginal Articles
  • In this issueReview ArticleSystematic ReviewOriginal ArticleCase Report
Show more In this issue

Similar Articles

CONTENT

  • home

JOURNAL

  • home

AUTHORS

  • home
Saudi Medical Journal

© 2025 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

Powered by HighWire