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NewsThe Cochrane Library Newsalert
Open Access

Does having more chronic conditions increase older adults’ risk of declining kidney function?

Saudi Medical Journal January 2025, 46 (1) 110;
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DECEMBER 18, 2024 - Older adults with multiple chronic conditions may face a high risk of kidney function decline, according to new research published in the Journal of the American Geriatrics Society.

In the study, 3,094 older individuals from the Swedish National Study on Aging and Care in Kungsholmen were followed for 15 years.

There was an independent dose-response relationship between the number of chronic conditions and kidney function decline, so that as the number of chronic conditions increased, kidney function decline became more likely and steeper.

When considering the makeup of conditions rather than just the number, the risk of kidney function decline was especially high for people with cardiometabolic conditions. On the other hand, people with psychiatric and respiratory comorbidities did not appear to have elevated risks of kidney function decline, despite having a higher average number of conditions.

“Our findings emphasize the importance of a comprehensive assessment that considers not only the overall chronic disease burden, but also the complex interplay between diseases when evaluating the risk of kidney function decline in older adults,” said corresponding author Giorgi Beridze, MD, MMSc, of the Karolinska Institute and Stockholm University. “Individuals presenting with diseases that are characteristic of high-risk multimorbidity patterns may particularly benefit from increased kidney function monitoring, promotion of healthy lifestyle, and timely pharmacological interventions.”

URL upon publication: https://onlinelibrary.wiley.com/doi/10.1111/jgs.19298

Full citation: “Associations between multimorbidity and kidney function decline in old age: A population-based cohort study.” Giorgi Beridze, Lu Dai, Juan-Jesús Carrero, Alessandra Marengoni, Davide L. Vetrano, Amaia Calderón-Larrañaga. J Am Geriatr Soc. Published Online: 17 December 2024 (DOI: 10.1111/jgs.19298).

Copyright © 2019 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd., Reproduced with permission.

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This is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work.

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© 2025 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

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