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Research ArticleOriginal Article
Open Access

Safety and efficacy of weekly somapacitan for growth hormone deficiency in children

A 72-week observational study

Abdulmoein E. Al-Agha, Hasan M. Aljefri, Shahd E. Kafi, Aliaa S. Alamri and Abdullah A. Alghamdi
Saudi Medical Journal March 2025, 46 (3) 269-273; DOI: https://doi.org/10.15537/smj.2025.46.3.20240937
Abdulmoein E. Al-Agha
From the Department of Pediatric (Al-Agha, Aljefri, Kafi, Alamri); and from the Department of Community Medicine (Alghamdi), King Abdulaziz University Hospital, Jeddah, Kingdom of Saudi Arabia.
DCH, FRCPCH
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  • ORCID record for Abdulmoein E. Al-Agha
  • For correspondence: [email protected]
Hasan M. Aljefri
From the Department of Pediatric (Al-Agha, Aljefri, Kafi, Alamri); and from the Department of Community Medicine (Alghamdi), King Abdulaziz University Hospital, Jeddah, Kingdom of Saudi Arabia.
MBBS, MD
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Shahd E. Kafi
From the Department of Pediatric (Al-Agha, Aljefri, Kafi, Alamri); and from the Department of Community Medicine (Alghamdi), King Abdulaziz University Hospital, Jeddah, Kingdom of Saudi Arabia.
MBBS, SB-Peds
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Aliaa S. Alamri
From the Department of Pediatric (Al-Agha, Aljefri, Kafi, Alamri); and from the Department of Community Medicine (Alghamdi), King Abdulaziz University Hospital, Jeddah, Kingdom of Saudi Arabia.
MBBS
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Abdullah A. Alghamdi
From the Department of Pediatric (Al-Agha, Aljefri, Kafi, Alamri); and from the Department of Community Medicine (Alghamdi), King Abdulaziz University Hospital, Jeddah, Kingdom of Saudi Arabia.
MBBS
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Article Figures & Data

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  • Figure 1
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    Figure 1

    - Comparison of height velocity measurements by gender across sequential time intervals in patients receiving weekly somapacitan therapy.

  • Figure 2
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    Figure 2

    - Longitudinal changes in serum insulin-like growth factor-1 levels over 72 weeks for treatment-naive patients compared to patients switched from daily growth hormone therapy.

Tables

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    Table 1

    - Height velocity by gender across various intervals in patients receiving somapacitan therapy.

    IntervalsFemaleMaleP-values
    12 weeks8.82±5.238.96±5.150.800
    24 weeks8.05±3.958.58±3.720.499
    36 weeks8.91±3.658.73±2.560.831
    72 weeks7.83±5.807.88±1.730.603

    Values are presented as mean ± standard deviation (SD).

      • View popup
      Table 2

      - Height velocity comparison between naive and switched patients across different intervals.

      IntervalsNaiveSwitchedP-values
      12 weeks9.52±5.187.64±4.950.018
      24 weeks9.06±3.847.33±3.470.010
      36 weeks8.76±3.098.88±2.780.950
      72 weeks8.33±3.457.00±2.830.883

      Values are presented as mean ± standard deviation (SD).

        • View popup
        Table 3

        - Changes in insulin-like growth factor-1 levels between treatment-naive patients and patients switched from daily growth hormone therapy over specified intervals.

        TimeNaiveSwitched
        Baseline152.82±70.62202.86±131.62
        12 weeks277.71±106.25306.45±117.40
        24 weeks276.44±111.61332.59±135.89
        36 weeks300.01±94.57348.46±129.67
        72 weeks405.26±60.13456.85±17.32

        Values are presented as mean ± standard deviation (SD).

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        Saudi Medical Journal: 46 (3)
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        1 Mar 2025
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        Safety and efficacy of weekly somapacitan for growth hormone deficiency in children
        Abdulmoein E. Al-Agha, Hasan M. Aljefri, Shahd E. Kafi, Aliaa S. Alamri, Abdullah A. Alghamdi
        Saudi Medical Journal Mar 2025, 46 (3) 269-273; DOI: 10.15537/smj.2025.46.3.20240937

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        Safety and efficacy of weekly somapacitan for growth hormone deficiency in children
        Abdulmoein E. Al-Agha, Hasan M. Aljefri, Shahd E. Kafi, Aliaa S. Alamri, Abdullah A. Alghamdi
        Saudi Medical Journal Mar 2025, 46 (3) 269-273; DOI: 10.15537/smj.2025.46.3.20240937
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        Keywords

        • growth hormone
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        • effectiveness
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