Skip to main content

Main menu

  • Home
  • Content
    • Latest
    • Archive
    • home
  • Info for
    • Authors
    • Reviewers
    • Subscribers
    • Institutions
    • Advertisers
    • Join SMJ
  • About Us
    • About Us
    • Editorial Office
    • Editorial Board
  • More
    • Advertising
    • Alerts
    • Feedback
    • Folders
    • Help
  • Other Publications
    • NeuroSciences Journal

User menu

  • My alerts
  • Log in

Search

  • Advanced search
Saudi Medical Journal
  • Other Publications
    • NeuroSciences Journal
  • My alerts
  • Log in
Saudi Medical Journal

Advanced Search

  • Home
  • Content
    • Latest
    • Archive
    • home
  • Info for
    • Authors
    • Reviewers
    • Subscribers
    • Institutions
    • Advertisers
    • Join SMJ
  • About Us
    • About Us
    • Editorial Office
    • Editorial Board
  • More
    • Advertising
    • Alerts
    • Feedback
    • Folders
    • Help
  • Follow psmmc on Twitter
  • Visit psmmc on Facebook
  • RSS
In BriefBrief Communication
Open Access

Risk of malignancy in thyroid nodules Bethesda III sub classification into nuclear atypia and architectural atypia. A retrospective study

Fahad Alwadi, Mohammed Alessa, Elaf Abdulkarim Alamer, Hamad F. Alrabiah, Abdulaziz Alaraifi, Abdulaziz Alsalem, Majed Mohamed Pharaon and Rahaf Khalid Alhabib
Saudi Medical Journal April 2025, 46 (4) 425-428; DOI: https://doi.org/10.15537/smj.2025.46.4.202040805
Fahad Alwadi
From the Division of Otolaryngology-Head and Neck Surgery, Department of Surgery (Alwadi, Alessa, Alaraifi, Alsalem) and from the Department of Pathology and Laboratory Medicine (Pharaon, Alhabib), King Abdulaziz Medical City, Ministry of National Guard Health Affairs; from the Department of Otolaryngology-Head and Neck Surgery (Alessa) and from the College of Medicine (Alessa, Alrabiah), King Saud University; from the College of Medicine (Alamer), King Abdulaziz Medical City, Ministry of National Guard Health Affairs; and from the Department of Pathology and Laboratory Medicine King Abdulaziz Medical University for Health Sciences and Department of Pathology and Laboratory Medicine, King Abdullah International Medical Research Center (Pharaon), Riyadh, Kingdom of Saudi Arabia.
MBBS
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mohammed Alessa
From the Division of Otolaryngology-Head and Neck Surgery, Department of Surgery (Alwadi, Alessa, Alaraifi, Alsalem) and from the Department of Pathology and Laboratory Medicine (Pharaon, Alhabib), King Abdulaziz Medical City, Ministry of National Guard Health Affairs; from the Department of Otolaryngology-Head and Neck Surgery (Alessa) and from the College of Medicine (Alessa, Alrabiah), King Saud University; from the College of Medicine (Alamer), King Abdulaziz Medical City, Ministry of National Guard Health Affairs; and from the Department of Pathology and Laboratory Medicine King Abdulaziz Medical University for Health Sciences and Department of Pathology and Laboratory Medicine, King Abdullah International Medical Research Center (Pharaon), Riyadh, Kingdom of Saudi Arabia.
MBBS, FRCSC
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Elaf Abdulkarim Alamer
From the Division of Otolaryngology-Head and Neck Surgery, Department of Surgery (Alwadi, Alessa, Alaraifi, Alsalem) and from the Department of Pathology and Laboratory Medicine (Pharaon, Alhabib), King Abdulaziz Medical City, Ministry of National Guard Health Affairs; from the Department of Otolaryngology-Head and Neck Surgery (Alessa) and from the College of Medicine (Alessa, Alrabiah), King Saud University; from the College of Medicine (Alamer), King Abdulaziz Medical City, Ministry of National Guard Health Affairs; and from the Department of Pathology and Laboratory Medicine King Abdulaziz Medical University for Health Sciences and Department of Pathology and Laboratory Medicine, King Abdullah International Medical Research Center (Pharaon), Riyadh, Kingdom of Saudi Arabia.
MBBS
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Elaf Abdulkarim Alamer
  • For correspondence: [email protected]
Hamad F. Alrabiah
From the Division of Otolaryngology-Head and Neck Surgery, Department of Surgery (Alwadi, Alessa, Alaraifi, Alsalem) and from the Department of Pathology and Laboratory Medicine (Pharaon, Alhabib), King Abdulaziz Medical City, Ministry of National Guard Health Affairs; from the Department of Otolaryngology-Head and Neck Surgery (Alessa) and from the College of Medicine (Alessa, Alrabiah), King Saud University; from the College of Medicine (Alamer), King Abdulaziz Medical City, Ministry of National Guard Health Affairs; and from the Department of Pathology and Laboratory Medicine King Abdulaziz Medical University for Health Sciences and Department of Pathology and Laboratory Medicine, King Abdullah International Medical Research Center (Pharaon), Riyadh, Kingdom of Saudi Arabia.
MBBS
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Abdulaziz Alaraifi
From the Division of Otolaryngology-Head and Neck Surgery, Department of Surgery (Alwadi, Alessa, Alaraifi, Alsalem) and from the Department of Pathology and Laboratory Medicine (Pharaon, Alhabib), King Abdulaziz Medical City, Ministry of National Guard Health Affairs; from the Department of Otolaryngology-Head and Neck Surgery (Alessa) and from the College of Medicine (Alessa, Alrabiah), King Saud University; from the College of Medicine (Alamer), King Abdulaziz Medical City, Ministry of National Guard Health Affairs; and from the Department of Pathology and Laboratory Medicine King Abdulaziz Medical University for Health Sciences and Department of Pathology and Laboratory Medicine, King Abdullah International Medical Research Center (Pharaon), Riyadh, Kingdom of Saudi Arabia.
MBBS
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Abdulaziz Alsalem
From the Division of Otolaryngology-Head and Neck Surgery, Department of Surgery (Alwadi, Alessa, Alaraifi, Alsalem) and from the Department of Pathology and Laboratory Medicine (Pharaon, Alhabib), King Abdulaziz Medical City, Ministry of National Guard Health Affairs; from the Department of Otolaryngology-Head and Neck Surgery (Alessa) and from the College of Medicine (Alessa, Alrabiah), King Saud University; from the College of Medicine (Alamer), King Abdulaziz Medical City, Ministry of National Guard Health Affairs; and from the Department of Pathology and Laboratory Medicine King Abdulaziz Medical University for Health Sciences and Department of Pathology and Laboratory Medicine, King Abdullah International Medical Research Center (Pharaon), Riyadh, Kingdom of Saudi Arabia.
MBBS
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Majed Mohamed Pharaon
From the Division of Otolaryngology-Head and Neck Surgery, Department of Surgery (Alwadi, Alessa, Alaraifi, Alsalem) and from the Department of Pathology and Laboratory Medicine (Pharaon, Alhabib), King Abdulaziz Medical City, Ministry of National Guard Health Affairs; from the Department of Otolaryngology-Head and Neck Surgery (Alessa) and from the College of Medicine (Alessa, Alrabiah), King Saud University; from the College of Medicine (Alamer), King Abdulaziz Medical City, Ministry of National Guard Health Affairs; and from the Department of Pathology and Laboratory Medicine King Abdulaziz Medical University for Health Sciences and Department of Pathology and Laboratory Medicine, King Abdullah International Medical Research Center (Pharaon), Riyadh, Kingdom of Saudi Arabia.
MBBS
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Rahaf Khalid Alhabib
From the Division of Otolaryngology-Head and Neck Surgery, Department of Surgery (Alwadi, Alessa, Alaraifi, Alsalem) and from the Department of Pathology and Laboratory Medicine (Pharaon, Alhabib), King Abdulaziz Medical City, Ministry of National Guard Health Affairs; from the Department of Otolaryngology-Head and Neck Surgery (Alessa) and from the College of Medicine (Alessa, Alrabiah), King Saud University; from the College of Medicine (Alamer), King Abdulaziz Medical City, Ministry of National Guard Health Affairs; and from the Department of Pathology and Laboratory Medicine King Abdulaziz Medical University for Health Sciences and Department of Pathology and Laboratory Medicine, King Abdullah International Medical Research Center (Pharaon), Riyadh, Kingdom of Saudi Arabia.
MBBS
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • eLetters
  • Info & Metrics
  • References
  • PDF
Loading

References

  1. 1.↵
    1. Flemban AF,
    2. Kabrah S,
    3. Alahmadi H,
    4. Alqurashi RK,
    5. Turaes AS,
    6. Almaghrabi R et al.
    Patterns of Thyroid Cancer Mortality and Incidence in Saudi Arabia: A 30-Year Study. Diagnostics 2022; 12.
  2. 2.↵
    1. Alqahtani WS,
    2. Almufareh NA,
    3. Domiaty DM,
    4. Albasher G,
    5. Alduwish MA,
    6. Alkhalaf H et al.
    Epidemiology of cancer in Saudi Arabia thru 2010–2019: a systematic review with constrained meta-analysis. AIMS Public Health 2020; 7.
  3. 3.↵
    1. Cibas ES,
    2. Ali SZ.
    The 2017 Bethesda System for Reporting Thyroid Cytopathology. Thyroid 2017; 27.
  4. 4.↵
    1. Ali SZ,
    2. Baloch ZW,
    3. Cochand-Priollet B,
    4. Schmitt FC,
    5. Vielh P,
    6. Vanderlaan PA.
    The 2023 Bethesda System for Reporting Thyroid Cytopathology. Thyroid 2023; 33.
  5. 5.↵
    1. Erdogan-Durmus S,
    2. Balta H,
    3. Demirtas R,
    4. Kurt A.
    Malignancy rates of atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) cases: A tertiary center study. Acta Endocrinol (Copenh) 2021; 17.
  6. 6.↵
    1. Ioachim D.
    The Bethesda System for Reporting Thyroid Cytopathology 2nd Edition Revised 2018. Acta Endocrinologica (Bucharest) 2018; 14.
  7. 7.↵
    1. Johnson DN,
    2. Cavallo AB,
    3. Uraizee I,
    4. Tanager K,
    5. Lastra RR,
    6. Antic T et al.
    A proposal for separation of nuclear atypia and architectural atypia in Bethesda Category III (AUS/FLUS) based on differing rates of thyroid malignancy. Am J Clin Pathol 2019; 151.
  8. 8.
    1. Glass RE,
    2. Levy JJ,
    3. Motanagh SA,
    4. Vaickus LJ,
    5. Liu X.
    Atypia of undetermined significance in thyroid cytology: Nuclear atypia and architectural atypia are associated with different molecular alterations and risks of malignancy. Cancer Cytopathol 2021; 129.
  9. 9.↵
    1. Rosario PW,
    2. Calsolari MR.
    Importance of cytological subclassification of thyroid nodules with Bethesda category III cytology (AUS/FLUS) into architectural atypia only and nuclear atypia: A prospective study. Diagn Cytopathol 2017; 45.
  10. 10.↵
    1. Mosca L,
    2. Ferraz da Silva LF,
    3. Carneiro PC,
    4. Chacon DA,
    5. Furtado de Araujo-Neto VJ,
    6. Furtado de Araujo-Filho VJ et al.
    Malignancy rates for bethesda III subcategories in thyroid fine needle aspiration biopsy (FNAB). Clinics 2018; 73.
  11. 11.↵
    1. Liu X,
    2. Wang J,
    3. Du W,
    4. Dai L,
    5. Fang Q.
    Predictors of malignancy in thyroid nodules classified as Bethesda Category III. Front Endocrinol (Lausanne) 2022; 13.
  12. 12.↵
    1. Zarif H,
    2. Ghandurah S,
    3. Al-Garni M,
    4. Binmahfooz S,
    5. Alsaywid B,
    6. Satti M.
    Thyroid nodules cytopathology applying the Bethesda system with histopathological correlation. Saudi J Med Med Sci 2018; 6.
  13. 13.↵
    1. Zhao H,
    2. Guo HQ,
    3. Zhao LL,
    4. Cao J,
    5. Sun Y,
    6. Wang C et al.
    Subclassification of the Bethesda Category III (AUS/FLUS): A study of thyroid FNA cytology based on ThinPrep slides from the National Cancer Center in China. Cancer Cytopathol 2021; 129.
  14. 14.↵
    1. Kim SJ,
    2. Roh J,
    3. Baek JH,
    4. Hong SJ,
    5. Shong YK,
    6. Kim WB et al.
    Risk of malignancy according to sub-classification of the atypia of undetermined significance or follicular lesion of undetermined significance (AUS/FLUS) category in the Bethesda system for reporting thyroid cytopathology. Cytopathology 2017; 28.
  15. 15.↵
    1. Huang J,
    2. Shi H,
    3. Song M,
    4. Liang J,
    5. Zhang Z,
    6. Chen X et al.
    Surgical outcome and malignant risk factors in patients with thyroid nodule classified as Bethesda Category III. Front Endocrinol (Lausanne) 2021; 12.
PreviousNext
Back to top

In this issue

Saudi Medical Journal: 46 (4)
Saudi Medical Journal
Vol. 46, Issue 4
1 Apr 2025
  • Table of Contents
  • Cover (PDF)
  • Index by author
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on Saudi Medical Journal.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Risk of malignancy in thyroid nodules Bethesda III sub classification into nuclear atypia and architectural atypia. A retrospective study
(Your Name) has sent you a message from Saudi Medical Journal
(Your Name) thought you would like to see the Saudi Medical Journal web site.
Citation Tools
Risk of malignancy in thyroid nodules Bethesda III sub classification into nuclear atypia and architectural atypia. A retrospective study
Fahad Alwadi, Mohammed Alessa, Elaf Abdulkarim Alamer, Hamad F. Alrabiah, Abdulaziz Alaraifi, Abdulaziz Alsalem, Majed Mohamed Pharaon, Rahaf Khalid Alhabib
Saudi Medical Journal Apr 2025, 46 (4) 425-428; DOI: 10.15537/smj.2025.46.4.202040805

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Risk of malignancy in thyroid nodules Bethesda III sub classification into nuclear atypia and architectural atypia. A retrospective study
Fahad Alwadi, Mohammed Alessa, Elaf Abdulkarim Alamer, Hamad F. Alrabiah, Abdulaziz Alaraifi, Abdulaziz Alsalem, Majed Mohamed Pharaon, Rahaf Khalid Alhabib
Saudi Medical Journal Apr 2025, 46 (4) 425-428; DOI: 10.15537/smj.2025.46.4.202040805
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Bookmark this article

Jump to section

  • Article
    • ABSTRACT
    • Methods
    • Results
    • Discussion
    • Acknowledgment
    • Footnotes
    • References
  • Figures & Data
  • eLetters
  • References
  • Info & Metrics
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • No citing articles found.
  • Google Scholar

More in this TOC Section

  • Successful management of human parainfluenza virus-3 outbreak in a tertiary neonatal intensive care unit
  • Experience of pediatric liver disease at a university hospital in Western Saudi Arabia
Show more Brief Communication

Similar Articles

Keywords

  • thyroid neoplasms
  • thyroid nodule
  • thyroid cancer
  • atypia of undetermined significance
  • follicular lesion of undetermined significance

CONTENT

  • home

JOURNAL

  • home

AUTHORS

  • home
Saudi Medical Journal

© 2025 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

Powered by HighWire