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Systematic ReviewSystematic Review
Open Access

Breast cancer incidence after hormonal treatment for infertility

A meta-analysis of population-based studies

Amal Y. Zaman, Lama S. Alrefai, Dorar F. Alharbi, Rahaf A. Khurmi, Leen M. Abuanq, Ajyal A. Aljohani, Ibrahim M. Dighriri and Nada Elnugomi
Saudi Medical Journal May 2025, 46 (5) 441-449; DOI: https://doi.org/10.15537/smj.2025.46.5.20240544
Amal Y. Zaman
From the Department of Woman and Child Health (Zaman, Elnugomi), College of Medicine; from the College of Medicine (Alrefai, Alharbi, Khurmi, Abuanq, Aljohani), Taibah University, Al-Madinah Al-Munawarah, and from the Department of Pharmaceutical Care Services (Dighriri), King Abdulaziz Specialist Hospital, Taif, Kingdom of Saudi Arabia.
MD
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Lama S. Alrefai
From the Department of Woman and Child Health (Zaman, Elnugomi), College of Medicine; from the College of Medicine (Alrefai, Alharbi, Khurmi, Abuanq, Aljohani), Taibah University, Al-Madinah Al-Munawarah, and from the Department of Pharmaceutical Care Services (Dighriri), King Abdulaziz Specialist Hospital, Taif, Kingdom of Saudi Arabia.
MBBS, MD
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Dorar F. Alharbi
From the Department of Woman and Child Health (Zaman, Elnugomi), College of Medicine; from the College of Medicine (Alrefai, Alharbi, Khurmi, Abuanq, Aljohani), Taibah University, Al-Madinah Al-Munawarah, and from the Department of Pharmaceutical Care Services (Dighriri), King Abdulaziz Specialist Hospital, Taif, Kingdom of Saudi Arabia.
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Rahaf A. Khurmi
From the Department of Woman and Child Health (Zaman, Elnugomi), College of Medicine; from the College of Medicine (Alrefai, Alharbi, Khurmi, Abuanq, Aljohani), Taibah University, Al-Madinah Al-Munawarah, and from the Department of Pharmaceutical Care Services (Dighriri), King Abdulaziz Specialist Hospital, Taif, Kingdom of Saudi Arabia.
MBBS, MD
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Leen M. Abuanq
From the Department of Woman and Child Health (Zaman, Elnugomi), College of Medicine; from the College of Medicine (Alrefai, Alharbi, Khurmi, Abuanq, Aljohani), Taibah University, Al-Madinah Al-Munawarah, and from the Department of Pharmaceutical Care Services (Dighriri), King Abdulaziz Specialist Hospital, Taif, Kingdom of Saudi Arabia.
MBBS, MD
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Ajyal A. Aljohani
From the Department of Woman and Child Health (Zaman, Elnugomi), College of Medicine; from the College of Medicine (Alrefai, Alharbi, Khurmi, Abuanq, Aljohani), Taibah University, Al-Madinah Al-Munawarah, and from the Department of Pharmaceutical Care Services (Dighriri), King Abdulaziz Specialist Hospital, Taif, Kingdom of Saudi Arabia.
MBBS, MD
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Ibrahim M. Dighriri
From the Department of Woman and Child Health (Zaman, Elnugomi), College of Medicine; from the College of Medicine (Alrefai, Alharbi, Khurmi, Abuanq, Aljohani), Taibah University, Al-Madinah Al-Munawarah, and from the Department of Pharmaceutical Care Services (Dighriri), King Abdulaziz Specialist Hospital, Taif, Kingdom of Saudi Arabia.
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Nada Elnugomi
From the Department of Woman and Child Health (Zaman, Elnugomi), College of Medicine; from the College of Medicine (Alrefai, Alharbi, Khurmi, Abuanq, Aljohani), Taibah University, Al-Madinah Al-Munawarah, and from the Department of Pharmaceutical Care Services (Dighriri), King Abdulaziz Specialist Hospital, Taif, Kingdom of Saudi Arabia.
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References

  1. 1.↵
    1. Siegel RL,
    2. Miller KD,
    3. Jemal A.
    Cancer statistics, 2016. CA Cancer J Clin 2016; 66: 7-30.
    OpenUrlCrossRefPubMed
  2. 2.↵
    WHO. Breast cancer. [Updated 2024; accessed 2024 June 20]. Available from: https://www.who.int/news-room/fact-sheets/detail/breast-cancer?gad_source=1&gclid=CjwKCAiArva5BhBiEiwA-oTnXUUAXwRc5XBVQb1qjXkI-U8ryOcq-w0mk3HX_uWGiZ-2B26Mv5QS5hoCisYQAvD_BwE
  3. 3.↵
    1. Houghton SC,
    2. Hankinson SE.
    Cancer progress and priorities: breast cancer. Cancer Epidemiol Biomarkers Prev 2021; 30: 822-844.
    OpenUrlFREE Full Text
  4. 4.↵
    1. Lipworth L.
    Epidemiology of breast cancer. Eur J Cancer Prev 1995; 4: 7-30.
    OpenUrlCrossRefPubMedWeb of Science
  5. 5.↵
    1. Bernstein L.
    Epidemiology of endocrine-related risk factors for breast cancer. J Mammary Gland Biol Neoplasia 2002; 7: 3-15.
    OpenUrlCrossRefPubMedWeb of Science
  6. 6.↵
    1. Stewart LM,
    2. Holman CD,
    3. Aboagye-Sarfo P,
    4. Finn JC,
    5. Preen DB,
    6. Hart R.
    In vitro fertilization, endometriosis, nulliparity and ovarian cancer risk. Gynecol Oncol 2013; 128: 260-264.
    OpenUrlCrossRefPubMed
  7. 7.↵
    1. Andersen CY,
    2. Kelsey T,
    3. Mamsen LS,
    4. Vuong LN.
    Shortcomings of an unphysiological triggering of oocyte maturation using human chorionic gonadotropin. Fertil Steril 2020; 114: 200-208.
    OpenUrlPubMed
  8. 8.↵
    1. Franceschi S,
    2. La Vecchia C,
    3. Negri E,
    4. Guarneri S,
    5. Montella M,
    6. Conti E, et al.
    Fertility drugs and risk of epithelial ovarian cancer in Italy. Hum Reprod 1994; 9: 1673-1675.
    OpenUrlCrossRefPubMedWeb of Science
  9. 9.↵
    1. Quaas AM,
    2. Legro RS.
    Pharmacology of medications used for ovarian stimulation. Best Pract Res Clin Endocrinol Metab 2019; 33: 21-33.
    OpenUrl
  10. 10.↵
    1. Schüler-Toprak S,
    2. Treeck O,
    3. Ortmann O.
    Human chorionic gonadotropin and breast cancer. Int J Mol Sci 2017; 18: 1587.
    OpenUrlPubMed
  11. 11.↵
    1. Hortobagyi GN,
    2. Stemmer SM,
    3. Burris HA,
    4. Yap YS,
    5. Sonke GS,
    6. Hart L, et al.
    Overall survival with ribociclib plus letrozole in advanced breast cancer. N Engl J Med 2022; 386: 942-950.
    OpenUrlCrossRefPubMed
  12. 12.↵
    1. Liu X,
    2. Yue J,
    3. Pervaiz R,
    4. Zhang H,
    5. Wang L.
    Association between fertility treatments and breast cancer risk in women with a family history or BRCA mutations: a systematic review and meta-analysis. Front Endocrinol (Lausanne) 2022; 13: 986477.
    OpenUrlPubMed
  13. 13.↵
    1. Cumpston M,
    2. Li T,
    3. Page MJ,
    4. Chandler J,
    5. Welch VA,
    6. Higgins JP, et al.
    Updated guidance for trusted systematic reviews: a new edition of the Cochrane handbook for systematic reviews of interventions. Cochrane Database Syst Rev 2019; 10: ED000142.
    OpenUrlCrossRefPubMed
  14. 14.↵
    1. Page MJ,
    2. Moher D.
    Evaluations of the uptake and impact of the preferred reporting items for systematic reviews and meta-analyses (PRISMA) statement and extensions: a scoping review. Syst Rev 2017; 6: 263.
    OpenUrlCrossRefPubMed
  15. 15.↵
    1. Taheripanah R,
    2. Balash F,
    3. Anbiaee R,
    4. Mahmoodi M,
    5. Akbari Sene A.
    Breast cancer and ovulation induction treatments. Clin Breast Cancer 2018; 18: 395-399.
    OpenUrlPubMed
  16. 16.↵
    1. Orgéas CC,
    2. Sanner K,
    3. Hall P,
    4. Conner P,
    5. Holte J,
    6. Nilsson SJ, et al.
    Breast cancer incidence after hormonal infertility treatment in Sweden: a cohort study. Am J Obstet Gynecol 2009; 200: 72.
    OpenUrlPubMed
  17. 17.↵
    1. Calderon-Margalit R,
    2. Friedlander Y,
    3. Yanetz R,
    4. Kleinhaus K,
    5. Perrin MC,
    6. Manor O, et al.
    Cancer risk after exposure to treatments for ovulation induction. Am J Epidemiol 2009; 169: 365-375.
    OpenUrlCrossRefPubMedWeb of Science
  18. 18.↵
    1. Lerner-Geva L,
    2. Rabinovici J,
    3. Olmer L,
    4. Blumstein T,
    5. Mashiach S,
    6. Lunenfeld B.
    Are infertility treatments a potential risk factor for cancer development? Perspective of 30 years of follow-up. Gynecol Endocrinol 2012; 28: 809-814.
    OpenUrlCrossRefPubMed
  19. 19.↵
    1. Bıldırcın FD,
    2. Özdemir A,
    3. Karlı P,
    4. Çetinkaya MB.
    Breast cancer and ovulation induction. J Surg Med 2019; 3: 612-618.
    OpenUrl
  20. 20.↵
    1. Basudan AM.
    Breast cancer incidence patterns in the Saudi female population: a 17-year retrospective analysis. Medicina (Kaunas) 2022; 58: 1617.
    OpenUrlPubMed
  21. 21.↵
    1. Gauthier E,
    2. Paoletti X,
    3. Clavel-Chapelon F.
    Breast cancer risk associated with being treated for infertility: results from the French E3N cohort study. Hum Reprod 2004; 19: 2216-2221.
    OpenUrlCrossRefPubMedWeb of Science
  22. 22.↵
    1. Kotsopoulos J,
    2. Librach CL,
    3. Lubinski J,
    4. Gronwald J,
    5. Kim-Sing C,
    6. Ghadirian P, et al.
    Infertility, treatment of infertility, and the risk of breast cancer among women with BRCA1 and BRCA2 mutations: a case-control study. Cancer Causes Control 2008; 19: 1111-1119.
    OpenUrlCrossRefPubMedWeb of Science
  23. 23.↵
    1. Jensen A,
    2. Sharif H,
    3. Svare EI,
    4. Frederiksen K,
    5. Kjaer SK.
    Risk of breast cancer after exposure to fertility drugs: results from a large Danish cohort study. Cancer Epidemiol Biomarkers Prev 2007; 16: 1400-1407.
    OpenUrlAbstract/FREE Full Text
  24. 24.↵
    1. Reigstad MM,
    2. Larsen IK,
    3. Myklebust TÅ,
    4. Robsahm TE,
    5. Oldereid NB,
    6. Omland AK, et al.
    Risk of breast cancer following fertility treatment--a registry based cohort study of parous women in Norway. Int J Cancer 2015; 136: 1140-1148.
    OpenUrlCrossRefPubMed
  25. 25.↵
    1. Burkman RT,
    2. Tang MT,
    3. Malone KE,
    4. Marchbanks PA,
    5. McDonald JA,
    6. Folger SG, et al.
    Infertility drugs and the risk of breast cancer: findings from the National Institute of Child Health and Human Development Women’s Contraceptive and Reproductive Experiences study. Fertil Steril 2003; 79: 844-851.
    OpenUrlCrossRefPubMedWeb of Science
  26. 26.↵
    1. Terry KL,
    2. Willett WC,
    3. Rich-Edwards JW,
    4. Michels KB.
    A prospective study of infertility due to ovulatory disorders, ovulation induction, and incidence of breast cancer. Arch Intern Med 2006; 166: 2484-2489.
    OpenUrlCrossRefPubMedWeb of Science
  27. 27.↵
    1. Doyle P,
    2. Maconochie N,
    3. Beral V,
    4. Swerdlow AJ,
    5. Tan SL.
    Cancer incidence following treatment for infertility at a clinic in the UK. Hum Reprod 2002; 17: 2209-2213.
    OpenUrlCrossRefPubMedWeb of Science
  28. 28.↵
    1. Cooley A,
    2. Matthews L,
    3. Zelivianski S,
    4. Hardy A,
    5. Jeruss JS.
    Effect of infertility treatment and pregnancy-related hormones on breast cell proliferation in vitro. Hum Reprod 2012; 27: 146-152.
    OpenUrlCrossRefPubMed
  29. 29.
    1. Stewart LM,
    2. Holman CD,
    3. Hart R,
    4. Bulsara MK,
    5. Preen DB,
    6. Finn JC.
    In vitro fertilization and breast cancer: is there cause for concern? Fertil Steril 2012; 98: 334-340.
    OpenUrlCrossRefPubMed
  30. 30.↵
    1. Reigstad MM,
    2. Larsen IK,
    3. Myklebust TÅ,
    4. Robsahm TE,
    5. Oldereid NB,
    6. Omland AK, et al.
    Cancer risk among parous women following assisted reproductive technology. Hum Reprod 2015; 30: 1952-1963.
    OpenUrlCrossRefPubMed
  31. 31.↵
    1. Jensen A,
    2. Sharif H,
    3. Kjaer SK.
    Use of fertility drugs and risk of uterine cancer: results from a large Danish population-based cohort study. Am J Epidemiol 2009; 170: 1408-1414.
    OpenUrlCrossRefPubMedWeb of Science
  32. 32.↵
    1. Beebeejaun Y,
    2. Athithan A,
    3. Copeland TP,
    4. Kamath MS,
    5. Sarris I,
    6. Sunkara SK.
    Risk of breast cancer in women treated with ovarian stimulation drugs for infertility: a systematic review and meta-analysis. Fertil Steril 2021; 116: 198-207.
    OpenUrlPubMed
  33. 33.↵
    1. Cetin I,
    2. Cozzi V,
    3. Antonazzo P.
    Infertility as a cancer risk factor - a review. Placenta 2008; 29: 169-177.
    OpenUrlCrossRefPubMed
  34. 34.↵
    1. Silva Idos S,
    2. Wark PA,
    3. McCormack VA,
    4. Mayer D,
    5. Overton C,
    6. Little V, et al.
    Ovulation-stimulation drugs and cancer risks: a long-term follow-up of a British cohort. Br J Cancer 2009; 100: 1824-1831.
    OpenUrlCrossRefPubMedWeb of Science
  35. 35.↵
    1. Cullinane C,
    2. Gillan H,
    3. Geraghty J,
    4. Evoy D,
    5. Rothwell J,
    6. McCartan D, et al.
    Fertility treatment and breast-cancer incidence: meta-analysis. BJS Open 2022; 6: zrab149.
    OpenUrl
  36. 36.↵
    1. Sergentanis TN,
    2. Diamantaras AA,
    3. Perlepe C,
    4. Kanavidis P,
    5. Skalkidou A,
    6. Petridou ET.
    IVF and breast cancer: a systematic review and meta-analysis. Hum Reprod Update 2014; 20: 106-123.
    OpenUrlCrossRefPubMed
  37. 37.↵
    1. van den Belt-Dusebout AW,
    2. Spaan M,
    3. Lambalk CB,
    4. Kortman M,
    5. Laven JS,
    6. van Santbrink EJ, et al.
    Ovarian stimulation for in vitro fertilization and long-term risk of breast cancer. JAMA 2016; 316: 300-312.
    OpenUrlPubMed
  38. 38.↵
    1. Al-Shami K,
    2. Awadi S,
    3. Khamees A,
    4. Alsheikh AM,
    5. Al-Sharif S,
    6. Ala’ Bereshy R, et al.
    Estrogens and the risk of breast cancer: a narrative review of literature. Heliyon 2023; 9: e20224.
    OpenUrl
  39. 39.↵
    1. Satpathi S,
    2. Gaurkar SS,
    3. Potdukhe A,
    4. Wanjari MB.
    Unveiling the role of hormonal imbalance in breast cancer development: a comprehensive review. Cureus 2023; 15: e41737.
    OpenUrl
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Breast cancer incidence after hormonal treatment for infertility
Amal Y. Zaman, Lama S. Alrefai, Dorar F. Alharbi, Rahaf A. Khurmi, Leen M. Abuanq, Ajyal A. Aljohani, Ibrahim M. Dighriri, Nada Elnugomi
Saudi Medical Journal May 2025, 46 (5) 441-449; DOI: 10.15537/smj.2025.46.5.20240544

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Breast cancer incidence after hormonal treatment for infertility
Amal Y. Zaman, Lama S. Alrefai, Dorar F. Alharbi, Rahaf A. Khurmi, Leen M. Abuanq, Ajyal A. Aljohani, Ibrahim M. Dighriri, Nada Elnugomi
Saudi Medical Journal May 2025, 46 (5) 441-449; DOI: 10.15537/smj.2025.46.5.20240544
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