Skip to main content

Main menu

  • Home
  • Content
    • Latest
    • Archive
    • home
  • Info for
    • Authors
    • Reviewers
    • Subscribers
    • Institutions
    • Advertisers
    • Join SMJ
  • About Us
    • About Us
    • Editorial Office
    • Editorial Board
  • More
    • Advertising
    • Alerts
    • Feedback
    • Folders
    • Help
  • Other Publications
    • NeuroSciences Journal

User menu

  • My alerts
  • Log in

Search

  • Advanced search
Saudi Medical Journal
  • Other Publications
    • NeuroSciences Journal
  • My alerts
  • Log in
Saudi Medical Journal

Advanced Search

  • Home
  • Content
    • Latest
    • Archive
    • home
  • Info for
    • Authors
    • Reviewers
    • Subscribers
    • Institutions
    • Advertisers
    • Join SMJ
  • About Us
    • About Us
    • Editorial Office
    • Editorial Board
  • More
    • Advertising
    • Alerts
    • Feedback
    • Folders
    • Help
  • Follow psmmc on Twitter
  • Visit psmmc on Facebook
  • RSS
Research ArticleOriginal Article
Open Access

Effects of green tea and vitamin E in the testicular tissue of streptozotocin-induced diabetic rats

Gulnur T. Kaplanoglu, Meltem Bahcelioglu, Rabet Gozil, Fatma Helvacioglu, Ece Buru, Mustafa A. Tekindal, Deniz Erdogan and Engin Calguner
Saudi Medical Journal July 2013, 34 (7) 734-743;
Gulnur T. Kaplanoglu
Department of Histology and Embryology, Faculty of Medicine, Gazi University, Besevler 06500, Ankara, Turkey. Tel. +90 (532) 3859300. Fax. +90 (312) 2024647. E-mail: [email protected] / [email protected]
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: [email protected] [email protected]
Meltem Bahcelioglu
Department of Histology and Embryology, Faculty of Medicine, Gazi University, Besevler 06500, Ankara, Turkey. Tel. +90 (532) 3859300. Fax. +90 (312) 2024647. E-mail: [email protected] / [email protected]
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: [email protected] [email protected]
Rabet Gozil
Department of Histology and Embryology, Faculty of Medicine, Gazi University, Besevler 06500, Ankara, Turkey. Tel. +90 (532) 3859300. Fax. +90 (312) 2024647. E-mail: [email protected] / [email protected]
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: [email protected] [email protected]
Fatma Helvacioglu
Department of Histology and Embryology, Faculty of Medicine, Gazi University, Besevler 06500, Ankara, Turkey. Tel. +90 (532) 3859300. Fax. +90 (312) 2024647. E-mail: [email protected] / [email protected]
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: [email protected] [email protected]
Ece Buru
Department of Histology and Embryology, Faculty of Medicine, Gazi University, Besevler 06500, Ankara, Turkey. Tel. +90 (532) 3859300. Fax. +90 (312) 2024647. E-mail: [email protected] / [email protected]
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: [email protected] [email protected]
Mustafa A. Tekindal
Department of Histology and Embryology, Faculty of Medicine, Gazi University, Besevler 06500, Ankara, Turkey. Tel. +90 (532) 3859300. Fax. +90 (312) 2024647. E-mail: [email protected] / [email protected]
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: [email protected] [email protected]
Deniz Erdogan
Department of Histology and Embryology, Faculty of Medicine, Gazi University, Besevler 06500, Ankara, Turkey. Tel. +90 (532) 3859300. Fax. +90 (312) 2024647. E-mail: [email protected] / [email protected]
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: [email protected] [email protected]
Engin Calguner
Department of Histology and Embryology, Faculty of Medicine, Gazi University, Besevler 06500, Ankara, Turkey. Tel. +90 (532) 3859300. Fax. +90 (312) 2024647. E-mail: [email protected] / [email protected]
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: [email protected] [email protected]
  • Article
  • eLetters
  • Info & Metrics
  • PDF
Loading

Abstract

OBJECTIVE: To investigate the possible therapeutic or protective effects of green tea in diabetic rat's testicular tissue, either as a single agent, or together with vitamin E.

METHODS: The present study was carried out at the Faculty of Medicine, Gazi University, Ankara, Turkey from May to August 2011 for 10 weeks. Forty-eight adult male Wistar albino rats, weighting 250-300 g, were divided into 8 groups: control; nondiabetic vitamin E (0.4 mg/kg/NG); nondiabetic green tea (300 mg/kg/NG); nondiabetic vitamin E plus green tea administered groups; diabetic group (60 mg/kg/IV streptozotocin); diabetic vitamin E; diabetic green tea; and diabetic vitamin E plus green tea administered groups. Proliferative and apoptotic indexes were determined using anti-PCNA antibody immunohistochemistry and TUNEL assays respectively. Tubule degeneration was evaluated using the Johnson's score and also seminiferous tubules diameters, epithelial thickness were measured.

RESULTS: Histopathological examination in diabetic group revealed degenerative changes in the seminiferous tubules together with a statistically significant decrease in PCNA positive cells, in epithelial thickness, diameter of the tubules and in Johnson's score, while exhibited an increase in the number of apoptotic cells. When all these findings are considered together, the most successful protective effects in diabetes were obtained in the combined antioxidant group.

CONCLUSION: Combined therapy of vitamin E and green tea in diabetes was more effective than monotherapy. Therefore, these antioxidants may be use as a supporting therapy for reproductive dysfunction.

  • Copyright: © Saudi Medical Journal

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial License (CC BY-NC), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PreviousNext
Back to top

In this issue

Saudi Medical Journal: 34 (7)
Saudi Medical Journal
Vol. 34, Issue 7
1 Jul 2013
  • Table of Contents
  • Table of Contents (PDF)
  • Cover (PDF)
  • Index by author
Download PDF
Email Article

Thank you for your interest in spreading the word on Saudi Medical Journal.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Effects of green tea and vitamin E in the testicular tissue of streptozotocin-induced diabetic rats
(Your Name) has sent you a message from Saudi Medical Journal
(Your Name) thought you would like to see the Saudi Medical Journal web site.
Citation Tools
Effects of green tea and vitamin E in the testicular tissue of streptozotocin-induced diabetic rats
Gulnur T. Kaplanoglu, Meltem Bahcelioglu, Rabet Gozil, Fatma Helvacioglu, Ece Buru, Mustafa A. Tekindal, Deniz Erdogan, Engin Calguner
Saudi Medical Journal Jul 2013, 34 (7) 734-743;

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Effects of green tea and vitamin E in the testicular tissue of streptozotocin-induced diabetic rats
Gulnur T. Kaplanoglu, Meltem Bahcelioglu, Rabet Gozil, Fatma Helvacioglu, Ece Buru, Mustafa A. Tekindal, Deniz Erdogan, Engin Calguner
Saudi Medical Journal Jul 2013, 34 (7) 734-743;
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Bookmark this article

Jump to section

  • Article
  • eLetters
  • Info & Metrics
  • PDF

Related Articles

  • No related articles found.
  • Google Scholar

Cited By...

  • No citing articles found.
  • Google Scholar

More in this TOC Section

  • Longitudinal analysis of foodborne disease outbreaks in Saudi Arabia
  • Psychological stress and its association with bronchial asthma in Saudi Arabia
  • The factors affecting comfort and the comfort levels of patients hospitalized in the coronary intensive care unit
Show more Original Article

Similar Articles

CONTENT

  • home

JOURNAL

  • home

AUTHORS

  • home
Saudi Medical Journal

© 2025 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

Powered by HighWire