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Research ArticleOriginal Article
Open Access

The use of indomethacin for the prevention of intraventricular brain hemorrhage in high-risk neonates

Essam M. Al-Shawaf, Saleh A. Al-Alaiyan, Ali Y. Aqeel and Mohammed H. Gamal
Saudi Medical Journal March 2000, 21 (3) 274-277;
Essam M. Al-Shawaf
Department of Pediatrics, King Faisal Specialist Hospital & Research Centre, Riyadh, Kingdom of Saudi Arabia.
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Saleh A. Al-Alaiyan
Department of Pediatrics, King Faisal Specialist Hospital & Research Centre, PO Box 3354, Riyadh 11211, Kingdom of Saudi Arabia. Tel. +996 (1) 442 7761 Fax. +996 (1) 442 7784.
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Ali Y. Aqeel
Department of Pediatarics, King Faisal Specialist Hospital & Research Centre, Riyadh, Kingdom of Saudi Arabia.
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Mohammed H. Gamal
Department of Pediatrics, King Faisal Specialist Hospital & Research Centre, Riyadh, Kingdom of Saudi Arabia.
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Abstract

OBJECTIVE: The objective of this study was to determine the effect of indomethacin on reducing the incidence of intraventricular hemorrhage in premature infants treated in our units at King Faisal Specialist Hospital and Research Centre.

METHODS: This historical cohort study included 45 infants born with birth weights of 1250g or less and received indomethacin in the first 12 hours of life for intraventricular hemorrhage prevention. The treated infants were compared to 33 other infants with birth weights of 1250g or less who did not receive indomethacin for intraventricular hemorrhage prevention. Data collected included demographic, complications of prematurity, renal function and maternal data.

RESULTS: Mean birth weight (grams) and gestational age (week) were 928.6+/-34, 1066.2+/-38.9, 27.2+/-0.37 and 29+/-0.42 for the treated and the control infants. Overall incidence of intraventricular hemorrhage decreased significantly in the treated infants in comparison to the controls (P=0.0169). There was no infant with Grade 3-4 intraventricular hemorrhage found in the treated group while 2 developed grade 3-4 intraventricular in the control group which was insignificant. There were no statistically significant differences between the groups in terms of the complications of prematurity, Apgar scores at 5 minutes, airleak syndrome and the use of umbilical catheters. The total fluid intake in the first 4 days after starting the treatment was comparable between the groups. There were no significant differences between the groups in urine output in day 1, 3 and 4. However the urine output decreased significantly in day 2 in the treated group (P = 0.0349). There were no statistically significant differences in serum urea and creatinine between the groups.

CONCLUSION: Low dose indomethacin given in the first 12 hours of life was shown to be associated with a decrease in intraventricular hemorrhage in premature infants and it was not associated with significant adverse effect.

  • Copyright: © Saudi Medical Journal

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Saudi Medical Journal: 21 (3)
Saudi Medical Journal
Vol. 21, Issue 3
1 Mar 2000
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The use of indomethacin for the prevention of intraventricular brain hemorrhage in high-risk neonates
Essam M. Al-Shawaf, Saleh A. Al-Alaiyan, Ali Y. Aqeel, Mohammed H. Gamal
Saudi Medical Journal Mar 2000, 21 (3) 274-277;

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The use of indomethacin for the prevention of intraventricular brain hemorrhage in high-risk neonates
Essam M. Al-Shawaf, Saleh A. Al-Alaiyan, Ali Y. Aqeel, Mohammed H. Gamal
Saudi Medical Journal Mar 2000, 21 (3) 274-277;
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© 2023 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

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