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Research ArticleOriginal Article
Open Access

Effect of labor duration on fetal fibrinolysis. A pilot study

Shabih Manzar
Saudi Medical Journal June 2000, 21 (6) 543-544;
Shabih Manzar
Department of Pediatrics, King Fahd University Hospital, PO Box 40211, Al-Khobar, 31952, Kingdom of Saudi Arabia. Tel/Fax. +966 (3) 8976941.
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Abstract

OBJECTIVE: Activation of neonatal and maternal fibrinolysis at birth has been shown earlier. To evaluate further on the effect of labor duration on the fetal fibrinolysis, we conducted this preliminary study.

METHODS: An indirect assessment of activation of fetal fibrinolysis was carried out, by measuring the cord blood D-dimer. The cord blood samples were obtained randomly from 11 women undergoing vaginal delivery at term. Specimens were analyzed within 2 hours by using latex agglutination test. Pregnancy details were obtained from the delivery ward register.

RESULTS: The mean duration of labor was noted to be 5.4 hours (3.5- 9.46). The mean maternal age was 25.5 years (21-34). The mean gravidity was 2.4 (1-5) and the mean parity was 1.4 (1-4). No effect of duration of labor on the cord blood D-dimer concentration was observed.

CONCLUSION: Our findings suggested that it is not the time or duration of labor process that is involved in the activation of fetal fibrinolysis. The role of uterotropins and uterotonins (oxytocin, prostaglandins and endothelin-1), in activation of fetal fibrinolysis, should be evaluated in further studies.

  • Copyright: © Saudi Medical Journal

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Saudi Medical Journal: 21 (6)
Saudi Medical Journal
Vol. 21, Issue 6
1 Jun 2000
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Effect of labor duration on fetal fibrinolysis. A pilot study
Shabih Manzar
Saudi Medical Journal Jun 2000, 21 (6) 543-544;

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Effect of labor duration on fetal fibrinolysis. A pilot study
Shabih Manzar
Saudi Medical Journal Jun 2000, 21 (6) 543-544;
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© 2025 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

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