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Research ArticleOriginal Article
Open Access

Mycobacterium tuberculosis susceptibility in Saudi Arabia

Abdulrahman A. Alrajhi and Ali M. Al-Barrak
Saudi Medical Journal October 2002, 23 (10) 1227-1231;
Abdulrahman A. Alrajhi
Section of Infectious Diseases, Department of Medicine, King Faisal Specialist Hospital and Research Centre, MBC # 46, PO Box 3354, Riyadh 11211, Kingdom of Saudi Arabia. Tel. +996 (1) 4427494. Fax. +966 (1) 4427499. E-mail: [email protected]
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Ali M. Al-Barrak
Department of Medicine, Armed Forces Hospital, Riyadh, Kingdom of Saudi Arabia.
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Abstract

OBJECTIVE: To present the available susceptibility data of Mycobacterium tuberculosis (M. tuberculosis) isolates from the Kingdom of Saudi Arabia (KSA) published in peer-reviewed journals.

METHODS: In a meta-analysis, studies published between 1966 and 2001 were included. Publication sites include Medline-indexed and non-indexed. Numbers of grown and resistant isolates were tabulated for first-line anti-tuberculosis agents.

RESULTS: Twelve studies met the pre-set criteria. Data on 6,316 isolates between 1979 and 2000 were available. Resistance to at least one agent of the first-line anti-tuberculosis agents was 18.4%. Monoresistance to a single first-line agent was found in 10.9%, while polyresistance was noted in 7.6%. Multidrug-resistant M. tuberculosis was noted in 5.7% of all isolates. Resistance to isoniazid was most common noted in 11% of isolates. Resistance rates to other agents were: rifampin 9.7%, streptomycin 9.1%, pyrazinamide 3.1%, and ethambutol 2.5%. The overall resistance rate to at least one agent was not statistically different in isolates grown between 1979-1991 (18.5%) and 1989-2000 (18.3%). There were large regional variations and higher resistance rates in the Western and Southern regions.

CONCLUSION: Mycobacterium tuberculosis resistance rates to first-line antituberculosis agents and multidrug-resistant M. tuberculosis are high in KSA. A survey and monitoring program for drug-resistant tuberculosis will determine resistance rates at the community level.

  • Copyright: © Saudi Medical Journal

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Saudi Medical Journal: 23 (10)
Saudi Medical Journal
Vol. 23, Issue 10
1 Oct 2002
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Mycobacterium tuberculosis susceptibility in Saudi Arabia
Abdulrahman A. Alrajhi, Ali M. Al-Barrak
Saudi Medical Journal Oct 2002, 23 (10) 1227-1231;

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Mycobacterium tuberculosis susceptibility in Saudi Arabia
Abdulrahman A. Alrajhi, Ali M. Al-Barrak
Saudi Medical Journal Oct 2002, 23 (10) 1227-1231;
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© 2023 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

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