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Research ArticleOriginal Article
Open Access

Detection of extended-spectrum b-lactamases in members of the family enterobacteriaceae at a teaching hospital, Riyadh, Kingdom of Saudi Arabia

Hanan A. Babay
Saudi Medical Journal February 2002, 23 (2) 186-190;
Hanan A. Babay
Department of Pathology/Microbiology, King Khalid University Hospital, PO Box 2925, Riyadh 11461, Kingdom of Saudi Arabia. Fax. +966 (1) 4672462. E-mail: [email protected]
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Abstract

OBJECTIVE: To determine the prevalence of extended spectrum b-lactamase at King Khalid University Hospital, Riyadh, Kingdom of Saudi Arabia and to compare the ability of the disc diffusion, double disc potentiation methods and the extended-spectrum b-lactamase E test to detect exended-spectrum b-lactamase among enterobacteriaceae.

METHODS: This study was undertaken during the time period period January 1 through to September 30 1999, at King Khalid University Hospital, Riyadh, Kingdom of Saudi Arabia. A total of 187 multiresistant isolates of enterobacteriacae from different clinical specimens were tested for the extended-spectrum b-lactamases. The performance of disc diffusion, double disc potentiation methods using cefotaxime, ceftazidime, ceftriaxone and aztreonamand the extended-spectrum b-lactamase E based on the reduction of the minimum inhibitory concentration of ceftazidime in the presence of clavulanic acid were compared for the detection of extended-spectrum b-lactamase production.

RESULTS: Thirty six percent of our isolates produced extended-spectrum b-lactamases. Among these 42% were Klebsiella pneumoniae and 20% were Escherichia coli. Other species of Enterobacteriaceae produced extended-spectrum b-lactamase in low numbers. Disc diffusion method was not suitable for detecting extended-spectrum b-lactamases among the isolates. Double disc potentiation performed comparably well with the extended-spectrum b-lactamases E test.

CONCLUSION: Extended-spectrum b-lactamases occurs in Klebsiella pneumoniae and Escherichia coli at a significant number. The use of double disc potentiation method for screening is practical and the extended-spectrum b-lactamase E test with ceftazidime is a useful confirmatory test for extended-spectrum b-lactamase production.

  • Copyright: © Saudi Medical Journal

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Saudi Medical Journal: 23 (2)
Saudi Medical Journal
Vol. 23, Issue 2
1 Feb 2002
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Detection of extended-spectrum b-lactamases in members of the family enterobacteriaceae at a teaching hospital, Riyadh, Kingdom of Saudi Arabia
Hanan A. Babay
Saudi Medical Journal Feb 2002, 23 (2) 186-190;

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Detection of extended-spectrum b-lactamases in members of the family enterobacteriaceae at a teaching hospital, Riyadh, Kingdom of Saudi Arabia
Hanan A. Babay
Saudi Medical Journal Feb 2002, 23 (2) 186-190;
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© 2025 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

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