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Research ArticleOriginal Article
Open Access

Metallothionein expression in human prostate gland

Ziad M. Bataineh and Mohamad K. Nusier
Saudi Medical Journal November 2003, 24 (11) 1246-1249;
Ziad M. Bataineh
Associate Professor of Anatomy, Department of Anatomy, Jordan University of Science and Technology, School of Medicine, Irbid 22110, Jordan. Tel. +962 (2) 7201000 Ext. 23838. Fax. +962 (2) 7095010. E-mail: [email protected]
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Mohamad K. Nusier
Department of Biochemistry and Molecular Biology, Jordan University of Science and Technology, School of Medicine, Irbid, Jordan.
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Abstract

OBJECTIVE: This study is conducted to detect metallothionein (MT) distribution in the epithelial cells of prostate gland from patients with benign prostatic hypertrophy and adenocarcinoma.

METHODS: Prostatic tissues from patients with benign prostatic hypertrophy and adenocarcinoma were processed for immunocytochemistry using indirect peroxidase antiperoxidase procedure and primary antibody against MT. The samples were collected over a period of 2-3 years and were processed at Jordan University of Science and Technology, Irbid, Jordan in the year 2002.

RESULTS: All prostatic tissues showed a positive reaction for MT. In benign prostatic hypertrophy, MT was mainly localized in the nuclei of epithelial cells while in the adenocarcinoma; MT was mainly localized in the cytoplasm of the epithelial cells.

CONCLUSION: Metallothionein expression may be affected by the pathological status of the prostate. In addition, these findings could be used in diagnosing and evaluating the prognosis of different pathological conditions of the prostate.

  • Copyright: © Saudi Medical Journal

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Saudi Medical Journal: 24 (11)
Saudi Medical Journal
Vol. 24, Issue 11
1 Nov 2003
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Metallothionein expression in human prostate gland
Ziad M. Bataineh, Mohamad K. Nusier
Saudi Medical Journal Nov 2003, 24 (11) 1246-1249;

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Metallothionein expression in human prostate gland
Ziad M. Bataineh, Mohamad K. Nusier
Saudi Medical Journal Nov 2003, 24 (11) 1246-1249;
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© 2025 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

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