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Research ArticleOriginal Article
Open Access

Multi-drug resistance of Escherichia coli from the urinary tract

Akbar M. Rafay and Herbert N. Nsanze
Saudi Medical Journal March 2003, 24 (3) 261-264;
Akbar M. Rafay
Department of Microbiology and Immunology, Sultan Qaboos University Hospital, PO Box 259, Postal Code 113, Muscat, Sultanate of Oman. Tel. +968 515125. Fax. +968 515786. E-mail: [email protected]
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Herbert N. Nsanze
Department of Microbiology and Immunology, Sultan Qaboos University Hospital, Muscat, Sultanate of Oman.
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Abstract

OBJECTIVE: Resistance to antimicrobials of different structural classes has arisen in a multitude of bacterial species. This may complicate the therapeutic management of infections, including those of the urinary tract. The aim of this study is to show that antibiotic resistance surveillance is essential.

METHODS: A total of 11,126 urine samples were received at Sultan Qaboos University Hospital (SQUH), Muscat, Sultanate of Oman, for one year period (2001), they were cultured for bacterial pathogen and sensitivity was performed for all significant isolates.

RESULTS: Eight hundred and eighty-four samples were culture positive with Escherichia coli (E.coli) (N=445) as the most common enterobacteriaceae, followed by Klebsiella pneumoniae (N=161), unidentified Coliforms (N=56) and Klebsiella species (N=33). High rate of resistance to b-Lactams was seen for all Enterobacteriaceae, maximum resistance was against ampicillin (78.6%) followed by co-amoxiclav (44.6%), but cefuroxime demonstrated the least resistance. Resistance to quinolone ranged from 4.7%-21.2% for all Enterobacteriaceae, cotrimoxazole resistance for all Enterobacteriaceae was 32.1%. Multi-drug resistance of E.coli was analyzed, 11.2% (50 of 445) were resistant to 3 or more antimicrobials and considered multidrug resistant. Among the multidrug-resistant isolates, 88% were resistant co-amoxiclav or cotrimoxazole, gentamicin 62%, ciprofloxacin 66%, and nitrofurantoin 32%. The predominant phenotype among multidrug-resistant isolates (26%; 13 of 50) included resistance to co-amoxiclav, gentamicin, and cotrimoxazole. This was the most common phenotype followed by 20%, of co-amoxiclav, cotrimoxazole and ciprofloxacin.

CONCLUSION: In view of the current prevalence of multi-drug resistance among urinary tract isolates of E.coli at the SQUH (11.2%), continued surveillance will be beneficial.

  • Copyright: © Saudi Medical Journal

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Saudi Medical Journal: 24 (3)
Saudi Medical Journal
Vol. 24, Issue 3
1 Mar 2003
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Multi-drug resistance of Escherichia coli from the urinary tract
Akbar M. Rafay, Herbert N. Nsanze
Saudi Medical Journal Mar 2003, 24 (3) 261-264;

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Multi-drug resistance of Escherichia coli from the urinary tract
Akbar M. Rafay, Herbert N. Nsanze
Saudi Medical Journal Mar 2003, 24 (3) 261-264;
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© 2025 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

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