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Research ArticleOriginal Article
Open Access

P53 and heat shock protein 70 expressions in colorectal adenocarcinoma

Ali M. Shotar
Saudi Medical Journal October 2005, 26 (10) 1602-1606;
Ali M. Shotar
Department of Legal Medicine, Toxicology and Forensic Science, School of Medicine, Jordan University of Science and Technology, Irbid, PO Box 3030, Jordan. Tel. +962 (2) 7100483. Fax. +962 (2) 7205010. E-mail: [email protected]
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Abstract

OBJECTIVE: To examine the localization and over expression of heat shock protein 70 (HSP70) and p53 in patients with colorectal cancer and compared it with control tissue (including normal colon tissue).

METHODS: This was a retrospective study of 60 patients with colorectal adenocarcinoma at the Jordan University of Science and Technology (JUST), Irbid, Jordan from 1997 to 2000. The Pathology Department at JUST is the chief provider of surgical pathology services in the north of Jordan. It receives specimens from both government and private hospitals. Immunohistochemistry was the technique of choice.

RESULTS: The HSP70 was over expressed more highly in colorectal cancers than in the control tissue. Immuno-histochemistry showed that over expression of HSP70 had no statistically significant difference with any of the different prognostic factors assessed, mainly the grade and the stage. The p53 was over expressed in 60% of the cases. Control tissue (normal colon) was negative, p53, cell-cycle-related oncogene product, was strongly over expressed in the nuclei of the cancer cells of the cancer tissue. We found no significant difference in terms of size, patient age, lymph node state, and stage. The rate of expression was significantly less in high grade tumors than in intermediate and low grade ones.

CONCLUSION: The strong expression however, may be valuable in estimating a prognosis for patients with colo-rectal carcinoma.

  • Copyright: © Saudi Medical Journal

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Saudi Medical Journal: 26 (10)
Saudi Medical Journal
Vol. 26, Issue 10
1 Oct 2005
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P53 and heat shock protein 70 expressions in colorectal adenocarcinoma
Ali M. Shotar
Saudi Medical Journal Oct 2005, 26 (10) 1602-1606;

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P53 and heat shock protein 70 expressions in colorectal adenocarcinoma
Ali M. Shotar
Saudi Medical Journal Oct 2005, 26 (10) 1602-1606;
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© 2023 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

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