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Research ArticleOriginal Article
Open Access

Mechanism of CD11b down-regulation from phorbol myristate acetate stimulated polymorphonuclear neutrophils

Khalil A. Aziz
Saudi Medical Journal October 2005, 26 (10) 1596-1601;
Khalil A. Aziz
Regional Department of Immunology, Birmingham Heartlands Hospital, Bordesley Green East, Birmingham B9 5SS, United Kingdom. Tel. +44 (121) 4240185. Fax. +44 (121) 4243129. E-mail: [email protected]
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Abstract

OBJECTIVE: To investigate the mechanism of CD11b down-regulation in phorbol myristate acetate (PMA) stimulated polymorphonuclear leukocytes (PMN).

METHODS: Purified PMN were stimulated with PMA in the presence, or absence, of various enzyme inhibitors. Following stimulation, PMN CD11b expression was examined by flow cytometry and Western-blotting. The entire work was carried out at Liverpool University between the period of 1998 and 2001.

RESULTS: Stimulation of PMN with PMA induced the down-regulation of CD11b by a mechanism involving a combination of an oxidant and a serine protease; most likely the primary granule derived elastase.

CONCLUSION: The present study shows for the first time the cooperation of both oxidants and enzymes in the down-regulation of PMN adhesion receptors.

  • Copyright: © Saudi Medical Journal

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Saudi Medical Journal: 26 (10)
Saudi Medical Journal
Vol. 26, Issue 10
1 Oct 2005
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Mechanism of CD11b down-regulation from phorbol myristate acetate stimulated polymorphonuclear neutrophils
Khalil A. Aziz
Saudi Medical Journal Oct 2005, 26 (10) 1596-1601;

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Mechanism of CD11b down-regulation from phorbol myristate acetate stimulated polymorphonuclear neutrophils
Khalil A. Aziz
Saudi Medical Journal Oct 2005, 26 (10) 1596-1601;
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© 2023 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

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