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Research ArticleOriginal Article
Open Access

Molecular prevalence of point mutations conferring resistance to clarithromycin in Helicobacter pylori in the United Arab Emirates

Mubarak S. Alfaresi, Abdulla A. Eltom, Saeed S. Alshaikh, Elwin H. Buchel, Lamya S. Saeed and Monther M. Aljenaibi
Saudi Medical Journal May 2005, 26 (5) 763-766;
Mubarak S. Alfaresi
Clinical Microbiologist, Zayed Military Hospital, PO Box 3740, Abu-Dhabi, United Arab Emirates. Tel. +9712 4055863. Fax. +9712 4492075. E-mail: [email protected]
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  • For correspondence: [email protected]
Abdulla A. Eltom
Department of Gastroenterology and Endoscopy, Zayed Military Hospital, Abu-Dhabi, United Arab Emirates.
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Saeed S. Alshaikh
Department of Gastroenterology and Endoscopy, Zayed Military Hospital, Abu-Dhabi, United Arab Emirates.
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Elwin H. Buchel
Department of Gastroenterology and Endoscopy, Zayed Military Hospital, Abu-Dhabi, United Arab Emirates.
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Lamya S. Saeed
Department of Gastroenterology and Endoscopy, Zayed Military Hospital, Abu-Dhabi, United Arab Emirates.
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Monther M. Aljenaibi
Department of Gastroenterology and Endoscopy, Zayed Military Hospital, Abu-Dhabi, United Arab Emirates.
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Abstract

OBJECTIVE: The aim of the study was to find the prevalence of point mutations conferring resistance to clarithromycin in Helicobacter pylori (H. pylori) in the United Arab Emirates.

METHODS: Gastric biopsy samples were obtained from 9 dyspeptic patients attending the endoscopy department in Zayed Military Hospital, Abu-Dhabi, UAE during the period from January to September 2004. Real-time polymerase chain reaction (PCR) was carried out for these biopsies to determine the point mutations.

RESULTS: Of the 55 (60%) real-time biopsies that were PCR positive for H. pylori, 36 (65.5%) were found to have mutant genes. The A(2142/43)G mutation was more common (63.6%) than the A(2142)C mutation (18.2%).

CONCLUSION: Point mutations A(2442/43)G and A(2142)C and the combination of both were common among our patients. Perhaps the highest reported yet. Mutation at A(2142/43)G is far more common than mutation at A(2142)C.

  • Copyright: © Saudi Medical Journal

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Saudi Medical Journal: 26 (5)
Saudi Medical Journal
Vol. 26, Issue 5
1 May 2005
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Molecular prevalence of point mutations conferring resistance to clarithromycin in Helicobacter pylori in the United Arab Emirates
Mubarak S. Alfaresi, Abdulla A. Eltom, Saeed S. Alshaikh, Elwin H. Buchel, Lamya S. Saeed, Monther M. Aljenaibi
Saudi Medical Journal May 2005, 26 (5) 763-766;

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Molecular prevalence of point mutations conferring resistance to clarithromycin in Helicobacter pylori in the United Arab Emirates
Mubarak S. Alfaresi, Abdulla A. Eltom, Saeed S. Alshaikh, Elwin H. Buchel, Lamya S. Saeed, Monther M. Aljenaibi
Saudi Medical Journal May 2005, 26 (5) 763-766;
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© 2025 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

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