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Research ArticleOriginal Article
Open Access

The effect of acute normovolemic hemodilution and acute hypervolemic hemodilution on coagulation and allogeneic transfusion

Fatma Saricaoglu, Seda B. Akinci, Varol Celiker and Ulku Aypar
Saudi Medical Journal May 2005, 26 (5) 792-798;
Fatma Saricaoglu
Department of Anesthesiology and Reanimation, Hacettepe University Sihhiye, Ankara 06100,Turkey. Tel. +90 (312) 3051264. Fax. +90 (312) 3109600. E-mail: [email protected]
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Seda B. Akinci
Department of Anesthesiology and Reanimation, Medical Faculty, Hacettepe University, Sihhiye, Ankara, Turkey.
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Varol Celiker
Department of Anesthesiology and Reanimation, Medical Faculty, Hacettepe University, Sihhiye, Ankara, Turkey.
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Ulku Aypar
Department of Anesthesiology and Reanimation, Medical Faculty, Hacettepe University, Sihhiye, Ankara, Turkey.
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Abstract

OBJECTIVE: In this study, acute normovolemic hemodilution (ANH) and hypervolemic hemodilution (HHD) were compared with no hemodilution with regards to the effectiveness in blood usage and coagulation parameters.

METHODS: The study was performed from February to August 2001 at Hacettepe University Hospital, Ankara, Turkey. Thirty patients undergoing hip arthroplasty surgery were prospectively randomized into: ANH group [autologous blood 15 mL kg-1 was withdrawn and replaced by 6% hydroxyethylstarch (HES)] or HHD group (HES was administered without removal of any autologous blood) or the control group (no hemodilution). In all groups, blood was given when hemoglobin concentration was <9 g dl-1.

RESULTS: Three groups were clinically similar regarding blood loss, mean arterial pressures and coagulation parameters. But allogeneic transfusion requirements were significantly less in hemodilution groups (20% in ANH, 40% in HHD) compared to the control group (100% of patients).

CONCLUSION: We conclude that hemodilution (both ANH and HHD) decreases the demand for homologous blood without adversely affecting hemodynamics or coagulation parameters and HHD seems to be a simple and valuable alternative to ANH in orthopedic patient undergoing hip replacement.

  • Copyright: © Saudi Medical Journal

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Saudi Medical Journal: 26 (5)
Saudi Medical Journal
Vol. 26, Issue 5
1 May 2005
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The effect of acute normovolemic hemodilution and acute hypervolemic hemodilution on coagulation and allogeneic transfusion
Fatma Saricaoglu, Seda B. Akinci, Varol Celiker, Ulku Aypar
Saudi Medical Journal May 2005, 26 (5) 792-798;

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The effect of acute normovolemic hemodilution and acute hypervolemic hemodilution on coagulation and allogeneic transfusion
Fatma Saricaoglu, Seda B. Akinci, Varol Celiker, Ulku Aypar
Saudi Medical Journal May 2005, 26 (5) 792-798;
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© 2025 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

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