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Research ArticleOriginal Article
Open Access

An acquired form of Bernard Soulier syndrome associated with acute myeloid leukemia

Khalil A. Aziz
Saudi Medical Journal July 2005, 26 (7) 1095-1098;
Khalil A. Aziz
Senior Clinical Scientist, Regional Department of Immunology, Birmingham Heartlands Hospital, Bordesley Green East, Birmingham B9 5SS, United Kingdom. (Formerly affiliated to the University of Liverpool, Liverpool, United Kingdom). Tel. +1 (121) 4240185. Fax. +1 (121) 4243129. E-mail: [email protected]
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Abstract

OBJECTIVE: To investigate glycoprotein-1b (GP-1b) expression on platelets from patients with acute myeloid leukemia (AML).

METHODS: Purified platelets, obtained from AML-patients and normal control subjects, were examined for surface membrane GP1b-expression by flow cytometry and GP1b-mediated aggregation responses by aggregometry. The level of elastase in plasma from patients and controls was measured by enzymed-linked immunosorbent assay. The whole of this work was carried out at the University of Liverpool, Liverpool, United Kingdom during the period of 1994-2001.

RESULTS: Platelets from the majority of AML-patients showed reduced GP1b-expression and reduced GP1b-mediated aggregation responses. Reduction in platelet GP1b-expression was associated with increased plasma elastase levels.

CONCLUSION: The present study suggests that elastase, released from leukemic blasts, degrades platelet GP1b, resulting in dysfunctional circulating platelets in AML-patients. These results could explain the bleeding disorders observed in these patients.

  • Copyright: © Saudi Medical Journal

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial License (CC BY-NC), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Saudi Medical Journal: 26 (7)
Saudi Medical Journal
Vol. 26, Issue 7
1 Jul 2005
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An acquired form of Bernard Soulier syndrome associated with acute myeloid leukemia
Khalil A. Aziz
Saudi Medical Journal Jul 2005, 26 (7) 1095-1098;

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An acquired form of Bernard Soulier syndrome associated with acute myeloid leukemia
Khalil A. Aziz
Saudi Medical Journal Jul 2005, 26 (7) 1095-1098;
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© 2025 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

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