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Research ArticleOriginal Article
Open Access

The ultrastructural alterations in rat corneas with experimentally-induced diabetes mellitus

Gulnur Take, Gulten Karabay, Deniz Erdogan and Izzet Duyar
Saudi Medical Journal November 2006, 27 (11) 1650-1655;
Gulnur Take
Department of Histology and Embryology, Faculty of Medicine, Gazi University, Besevler 06500, Ankara, Turkey. Tel. +90 (312) 2024614 / +90 5323859300. Fax: +90 (312) 2124647. E-mail: [email protected]
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Gulten Karabay
Department of Histology and Embryology, School of Medicine, Baskent University, Turkey.
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Deniz Erdogan
Department of Histology and Embryology, School of Medicine, Gazi University, Turkey.
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Izzet Duyar
Department of Anthropology, Scholl of Letters, Ankara University, Ankara, Turkey.
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Abstract

OBJECTIVE: To examine the ultrastructural changes of rat corneas in streptozotocin (STZ) induced diabetes mellitus and the follow-up insulin treatment.

METHODS: Sprague-Dawley type rats was used for experimental procedures during the period from January to April 2003 at Baskent University, Ankara, Turkey. Rats were studied in 4 groups; group 1: controls, group 2: sham controls (single dose IV sodium citrate), group 3: STZ-induced diabetes mellitus (single dose 45 mg/kg STZ intravenously), group 4: diabetes mellitus + insulin treatment (8 U/day).

RESULTS: We observed degenerative changes in the epithelial layer, stromal keratocytes and endothelial cells in diabetic group. In contrast, the corneal layers have revealed positive alterations in the insulin-treated group. The statistical analyses showed significant narrowing in the epithelial layer in the diabetic group (p=0.002), whereas thickening was observed in the epithelial basement membrane and Descemet's membrane (p=0.002).

CONCLUSION: It was determined that diabetes mellitus causes degenerative changes in cornea, which are positively influenced by short-term insulin treatment.

  • Copyright: © Saudi Medical Journal

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial License (CC BY-NC), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Saudi Medical Journal: 27 (11)
Saudi Medical Journal
Vol. 27, Issue 11
1 Nov 2006
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The ultrastructural alterations in rat corneas with experimentally-induced diabetes mellitus
Gulnur Take, Gulten Karabay, Deniz Erdogan, Izzet Duyar
Saudi Medical Journal Nov 2006, 27 (11) 1650-1655;

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The ultrastructural alterations in rat corneas with experimentally-induced diabetes mellitus
Gulnur Take, Gulten Karabay, Deniz Erdogan, Izzet Duyar
Saudi Medical Journal Nov 2006, 27 (11) 1650-1655;
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© 2025 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

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