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Research ArticleOriginal Article
Open Access

Morphologic alterations and immunohistochemical analysis of alpha-fetoprotein and CD34 in chorionic villi of anembryonic pregnancy

Sevim Aydin, Mehmet Ozeren, Engin Yenilmez, Esin Yulug, Umit Cobanoglu and Haluk Arvas
Saudi Medical Journal February 2006, 27 (2) 154-160;
Sevim Aydin
Karadeniz Teknik Universitesi, Tip Fakultesi Farabi Hastanesi, Histoloji ve Embriyoloji Anabilim Dali, 61080, Trabzon, Turkey. Tel. +90 (462) 3775516. Fax. +90 (462) 3252270. E-mail: [email protected]
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Mehmet Ozeren
Department of Obstetrics and Gynecology
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Engin Yenilmez
Department of Histology and Embryology
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Esin Yulug
Department of Histology and Embryology
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Umit Cobanoglu
Department of Pathology, Karadeniz Technical University, School of Medicine, Trabzon, Turkey.
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Haluk Arvas
Department of Histology and Embryology
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Abstract

OBJECTIVE: To investigate the morphology of chorionic villi using light and electron microscopy, especially the expression of alpha-fetoprotein (AFP) in trophoblastic cells and the process of maturation and margination vasculogenesis proper using CD34 immunohistochemistry in tissues from the first trimester of pregnancy loss due to anembryonic pregnancy in comparison with embryonic pregnancy.

METHODS: The study consisted of 2 groups: 9 patients with anembryonic pregnancies and 9 patients with embryonic pregnancies between 6 and 10 weeks of gestational age registered at the Department of Gynecology and Obstetrics, University Hospital of Karadeniz Technical University, Turkey, from March 2003 to December 2004. We examined the chorionic villi using light and electron microscopy. For immunohistochemical staining, we used AFP and CD34.

RESULTS: Microscopically, pathologic changes were shown in syncytiotrophoblast cells of anembryonic pregnancies and AFP was strongly expressed by villous trophoblastic cells compared to embryonic pregnancies. We determined the CD34 positivity in both groups. In anembryonic pregnancies, vascular elements were much fewer in number compared with embryonic pregnancies (p<0.001) and were located in the formed of hemangioblastic cords.

CONCLUSION: Placental vasculogenesis is a basic feature in all types of pregnancy and a relationship exists between trophoblast cells and vessels in the chorionic villi with the potential to influence each other's functions. Defective chorionic villus vascularization is associated with embryonic death. This study may support the hypothesis, as suggested by previous studies, that anembryonic pregnancy results from early embryonic death and subsequent reabsorption rather than from the nondevelopment of an embryo.

  • Copyright: © Saudi Medical Journal

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Saudi Medical Journal: 27 (2)
Saudi Medical Journal
Vol. 27, Issue 2
1 Feb 2006
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Morphologic alterations and immunohistochemical analysis of alpha-fetoprotein and CD34 in chorionic villi of anembryonic pregnancy
Sevim Aydin, Mehmet Ozeren, Engin Yenilmez, Esin Yulug, Umit Cobanoglu, Haluk Arvas
Saudi Medical Journal Feb 2006, 27 (2) 154-160;

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Morphologic alterations and immunohistochemical analysis of alpha-fetoprotein and CD34 in chorionic villi of anembryonic pregnancy
Sevim Aydin, Mehmet Ozeren, Engin Yenilmez, Esin Yulug, Umit Cobanoglu, Haluk Arvas
Saudi Medical Journal Feb 2006, 27 (2) 154-160;
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© 2025 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

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