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Research ArticleOriginal Article
Open Access

Does thyroid replacement therapy affect pulmonary function tests in patients with subclinical hypothyroidism?

Lokman Koral, Zeliha Hekimsoy, Cetin Yildirim, Bilgin Ozmen, Arzu Yorgancioglu and Alpaslan Girgin
Saudi Medical Journal March 2006, 27 (3) 329-332;
Lokman Koral
Department of Internal Medicine, Medical Faculty, Celal Bayar University, Manisa, Turkey.
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Zeliha Hekimsoy
Department of Internal Medicine, Division of Endocrinology and Metabolism, Medical Faculty, Celal Bayar University, Manisa, Turkey. E-mail: [email protected]
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  • For correspondence: [email protected]
Cetin Yildirim
Department of Pulmonology, Medical Faculty, Celal Bayar University, Manisa, Turkey.
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Bilgin Ozmen
Department of Internal Medicine, Division of Endocrinology and Metabolism Medical Faculty, Celal Bayar University, Manisa, Turkey.
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Arzu Yorgancioglu
Department of Pulmonology, Medical Faculty, Celal Bayar University, Manisa, Turkey.
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Alpaslan Girgin
Department of Internal Medicine, Medical Faculty, Medical Faculty, Celal Bayar University, Manisa, Turkey.
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Abstract

OBJECTIVE: Subclinical hypothyroidism is an elevation in serum thyroid-stimulating hormone (TSH) while having normal serum free thyroxine (FT4) and triiodothyronine (FT3) levels. The purpose of this prospective observational study was to evaluate the pulmonary function of patients diagnosed with subclinical hypothyroidism, both before and after treatment with thyroid hormone.

METHODS: This study took place at the Medical Faculty, Celal Bayar University, Manisa, Turkey between February 2003 and June 2004. Thirty-eight patients (37 females, one male) with subclinical hypothyroidism between 20 and 65 years of age were included in the study. Most were mildly obese. Arterial blood gases and pulmonary function tests were performed before treatment with thyroid hormone, and afterwards, the TSH value reached the normal range (indicating euthyroidism).

RESULTS: Oxygen saturation, but not partial oxygen pressure or partial carbon dioxide pressure, was statistically, but not clinically significantly higher after treatment with thyroid hormone (p=0.01). Pulmonary function tests were not significantly different before and after treatment with thyroid hormone.

CONCLUSION: In our subclinical hypothyroidism patients, pulmonary function tests were normal and did not significantly change with thyroid hormone replacement. The advantages of thyroid hormone replacement therapy, at least regarding respiratory function, seem to be clearly present in patients with overt, clinical hypothyroidism but not in patients with subclinical hypothyroidism.

  • Copyright: © Saudi Medical Journal

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Saudi Medical Journal: 27 (3)
Saudi Medical Journal
Vol. 27, Issue 3
1 Mar 2006
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Does thyroid replacement therapy affect pulmonary function tests in patients with subclinical hypothyroidism?
Lokman Koral, Zeliha Hekimsoy, Cetin Yildirim, Bilgin Ozmen, Arzu Yorgancioglu, Alpaslan Girgin
Saudi Medical Journal Mar 2006, 27 (3) 329-332;

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Does thyroid replacement therapy affect pulmonary function tests in patients with subclinical hypothyroidism?
Lokman Koral, Zeliha Hekimsoy, Cetin Yildirim, Bilgin Ozmen, Arzu Yorgancioglu, Alpaslan Girgin
Saudi Medical Journal Mar 2006, 27 (3) 329-332;
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© 2025 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

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