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Research ArticleOriginal Article
Open Access

Colorectal carcinoma from Saudi Arabia. Analysis of MLH-1, MSH-2 and p53 genes by immunohistochemistry and tissue microarray analysis.

Khawla S. Al-Kuraya, Prashant P. Bavi, Adnan A. Ezzat, Fouad A. Al-Dayel, Shahab Uddin, Valerie L. Atizado, Naif A. Al-Jomah, Samir S. Amr, Salwa S. Sheikh, Guido Sauter and Ronald Simon
Saudi Medical Journal March 2006, 27 (3) 323-328;
Khawla S. Al-Kuraya
Director, Biological Repository Centre and Director, Research Centre at King Fahad National Centre for Children's Cancer and Research, King Faisal Specialist Hospital and Research Centre, MBC 98-16, PO Box 3354, Riyadh 11211, Kingdom of Saudi Arabia. Tel. +966 (1) 2294444 Ext. 51813, +966 (1) 2055166. Fax. +966 (1) 2055170. E-mail: [email protected]
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  • For correspondence: [email protected]
Prashant P. Bavi
Research Centre, King Faisal Specialist Hospital and Research Centre, Riyadh
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Adnan A. Ezzat
Clinical Operations, King Faisal Specialist Hospital and Research Centre, Riyadh, Kingdom of Saudi Arabia.
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Fouad A. Al-Dayel
Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh
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Shahab Uddin
Research Centre, King Faisal Specialist Hospital and Research Centre, Riyadh, Kingdom of Saudi Arabia
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Valerie L. Atizado
Research Centre, King Faisal Specialist Hospital and Research Centre, Riyadh
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Naif A. Al-Jomah
Research Centre, King Faisal Specialist Hospital and Research Centre, Riyadh, Kingdom of Saudi Arabia.
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Samir S. Amr
Pathology Services Division, Saudi Aramco, Dhahran Health Centre, Dhahran, Kingdom of Saudi Arabia
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Salwa S. Sheikh
Pathology Services Division, Saudi Aramco, Dhahran Health Centre, Dhahran, Kingdom of Saudi Arabia
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Guido Sauter
Department of Pathology, University Medical Center Hamburg Eppendorf, Hamburg, Germany.
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Ronald Simon
Department of Pathology, University Medical Center Hamburg Eppendorf, Hamburg, Germany.
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Abstract

OBJECTIVE: To document the incidence and role of p53 and DNA mismatch repair proteins in colorectal carcinomas, and to evaluate the relative frequency of major molecular pathways in colorectal cancers from Saudi Arabia.

METHODS: We collected the formalin fixed, paraffin embedded tissues from 154 colorectal tumors (83 patients from King Faisal Specialist Hospital and Research Centre and 71 from Saudi Aramco Dhahran Health Centre) between January 1989 and December 2003. We analyzed the p53 and mismatch repair gene expression (hMSH-2, hMLH-1) by immunohistochemistry in tissue microarray format.

RESULTS: Expression loss of at least one mismatch repair gene was found in 33.8% of cases and significantly associated with the right-sided tumor location (p=0.0047). The p53 positivity was observed in 57.5% of tumors, and was inversely linked to expression loss of mismatch repair genes (p=0.0102).

CONCLUSION: The strong confirmation of the previously established associations between tumor phenotype, and mismatch repair gene alteration provided strong evidence for the validity of our experimental approach. Together with the higher incidence of right sided location in Saudi (46.6%) than in Western colon cancers (34.9%), the observed high prevalence of mismatch gene expression loss in Saudi tumors argues for a higher importance of microsatellite instability in this population. If confirmed, it will be interesting to see whether an increased level of familial or sporadic microsatellite instability cases is causing this variation.

  • Copyright: © Saudi Medical Journal

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Saudi Medical Journal: 27 (3)
Saudi Medical Journal
Vol. 27, Issue 3
1 Mar 2006
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Colorectal carcinoma from Saudi Arabia. Analysis of MLH-1, MSH-2 and p53 genes by immunohistochemistry and tissue microarray analysis.
Khawla S. Al-Kuraya, Prashant P. Bavi, Adnan A. Ezzat, Fouad A. Al-Dayel, Shahab Uddin, Valerie L. Atizado, Naif A. Al-Jomah, Samir S. Amr, Salwa S. Sheikh, Guido Sauter, Ronald Simon
Saudi Medical Journal Mar 2006, 27 (3) 323-328;

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Colorectal carcinoma from Saudi Arabia. Analysis of MLH-1, MSH-2 and p53 genes by immunohistochemistry and tissue microarray analysis.
Khawla S. Al-Kuraya, Prashant P. Bavi, Adnan A. Ezzat, Fouad A. Al-Dayel, Shahab Uddin, Valerie L. Atizado, Naif A. Al-Jomah, Samir S. Amr, Salwa S. Sheikh, Guido Sauter, Ronald Simon
Saudi Medical Journal Mar 2006, 27 (3) 323-328;
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© 2025 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

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