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Research ArticleOriginal Article
Open Access

Comparing the clinical, histopathological and myoepithelial features of estrogen receptor positive and negative mammary carcinomas

Zuhal Gucin, Bilgin Aksoy, Feray Gunver, Esra Pasaoglu and Fadime Bahadir
Saudi Medical Journal April 2006, 27 (4) 470-476;
Zuhal Gucin
Pathology Department, Istanbul Training and Research Hospital, Ministry of Health, Istanbul, Turkey. Tel. +90 (212) 5884400 Ext.1812. E-mail: [email protected]
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  • For correspondence: [email protected]
Bilgin Aksoy
Department of Pathology, Istanbul Training and Research Hospital, Ministry of Health, Istanbul, Turkey.
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Feray Gunver
Department of Pathology, Istanbul Training and Research Hospital, Ministry of Health, Istanbul, Turkey.
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Esra Pasaoglu
Department of Pathology, Istanbul Training and Research Hospital, Ministry of Health, Istanbul, Turkey.
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Fadime Bahadir
Department of Pathology, Istanbul Training and Research Hospital, Ministry of Health, Istanbul, Turkey.
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Abstract

OBJECTIVE: The purpose of this study is to examine the relationship between hormone-receptor status and histological parameters, considering that some estrogen receptor (ER)-negative breast carcinoma are suggested to be of myoepithelial origin or differentiation; and to examine the presence of significant difference by myoepithelial markers and define their morphologies.

METHODS: For this research, 30 estrogen receptor-negative and 31 estrogen receptor-positive breast carcinomas diagnosed at the Pathology Department, Istanbul Training and Education Hospital, Istanbul, Turkey, between February 2003 and October 2004 were considered and compared clinically, microscopically and immunohistochemically considering myoepithelial markers using SMA, S100, keratin14.

RESULTS: We found a higher amount of grade 3 frequency pushing margins, solid islets, and presence of central necrosis in the estrogen receptor-negative group than in the positive group (p<0.001 and p<0.05). Six estrogen-negative and 2 estrogen-positive cases were found positive for myoepithelial markers; a difference which is non-significant (p=0.147). The presence of solid islets, fusiform, and clear cells was detected higher in myoepithelial positive tumors than in negative group (p<0.05).

CONCLUSION: For daily pathologic applications, some morphological properties of a breast carcinoma can give clues about ER and myoepithelial features. In estrogen receptor-negative tumors, there is a remarkable myoepithelial marker positivity. Studies involving broader series and different myoepithelial markers could give more reliable results.

  • Copyright: © Saudi Medical Journal

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial License (CC BY-NC), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Saudi Medical Journal: 27 (4)
Saudi Medical Journal
Vol. 27, Issue 4
1 Apr 2006
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Comparing the clinical, histopathological and myoepithelial features of estrogen receptor positive and negative mammary carcinomas
Zuhal Gucin, Bilgin Aksoy, Feray Gunver, Esra Pasaoglu, Fadime Bahadir
Saudi Medical Journal Apr 2006, 27 (4) 470-476;

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Comparing the clinical, histopathological and myoepithelial features of estrogen receptor positive and negative mammary carcinomas
Zuhal Gucin, Bilgin Aksoy, Feray Gunver, Esra Pasaoglu, Fadime Bahadir
Saudi Medical Journal Apr 2006, 27 (4) 470-476;
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© 2025 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

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