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Research ArticleOriginal Article
Open Access

Comparison of the antiemetic effects of ondansetron and dexamethasone on middle ear surgery

Berrin Isik, Nedim Cekmen, Mustafa Arslan, Ozgur Ozsoylar, Aysegul Z. Kordan and Mehmet Akcabay
Saudi Medical Journal May 2006, 27 (5) 646-651;
Berrin Isik
Department of Anesthesiology and Reanimation, Faculty of Medicine, Gazi University, Bsevler, Ankara, Turkey.
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Nedim Cekmen
Department of Anesthesiology and Reanimation, Faculty of Medicine, Gazi University, Bsevler, Ankara, Turkey.
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Mustafa Arslan
48. Sokak, Seda Apartman?, 24/17, Yenimahalle-Kirikkale, Turkey. Tel. +90 (318) 2120526. E-mail: [email protected] / [email protected].
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  • For correspondence: [email protected] [email protected].
Ozgur Ozsoylar
Department of Anesthesiology and Reanimation, Faculty of Medicine, Gazi University, Bsevler, Ankara, Turkey.
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Aysegul Z. Kordan
Department of Anesthesiology and Reanimation, Faculty of Medicine, Gazi University, Bsevler, Ankara, Turkey.
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Mehmet Akcabay
Department of Anesthesiology and Reanimation, Faculty of Medicine, Gazi University, Bsevler, Ankara, Turkey.
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Abstract

OBJECTIVE: To compare the antiemetic efficacy of ondansetron and dexamethasone in adults undergoing middle ear surgery.

METHODS: This clinical research took place in the Faculty of Medicine, Gazi University, Turkey between January to December 2004. The study included 60 cases, classified by the American Society of Anesthesiology physical status group I-II, who underwent middle ear surgery. We carried out anesthesia induction with 5 mg.kg-1 sodium thiopental and performed muscle relaxation with 0.5 mg.kg-1 atracurium to be followed by orotracheal intubation. Anesthesia was maintained at 5 L.min-1 gas flows with 2-3% sevoflurane inhalation in 70/30% O2/N2O. We randomly distributed the cases into 2 groups, and the first group (Group O) was administered with 4 mg ondansetron intravenously (IV) at the stage of surgical skin closure and the second group (Group D) with 5 mg dexamethasone IV immediately after anesthesia induction. In the first 24 hours postoperatively, nausea vomiting score (NVS) and nausea, vomiting frequency, Metamizole-Na and non-steroidal anti-inflammatory drug use, the need for additional antiemetics and cost as well as the number of cases with nausea, vomiting and the need for extra antiemetics during 0-4, 4-12 and 12-24 hours were recorded, and their distribution to groups was evaluated.

RESULTS: The NVS was 0 (0-0) in group O compared with 1 (0-3) in group D (p=0.003). The use of additional antiemetics was found to be significantly lower in group O (1 ± 0.6) compared with group D (3.70 ± 1.02) (p=0.028). In comparing the cost, group O (9.8 dollars) was found to have a significantly higher cost compared with group D (1.1 dollars) (p<0.0001).

CONCLUSION: Ondansetron had a more significant effect on nausea and vomiting in the early period, however, no difference was found after 4 hours of administration. Furthermore, dexamethasone was found to cost less compared with ondansetron.

  • Copyright: © Saudi Medical Journal

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Saudi Medical Journal: 27 (5)
Saudi Medical Journal
Vol. 27, Issue 5
1 May 2006
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Comparison of the antiemetic effects of ondansetron and dexamethasone on middle ear surgery
Berrin Isik, Nedim Cekmen, Mustafa Arslan, Ozgur Ozsoylar, Aysegul Z. Kordan, Mehmet Akcabay
Saudi Medical Journal May 2006, 27 (5) 646-651;

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Comparison of the antiemetic effects of ondansetron and dexamethasone on middle ear surgery
Berrin Isik, Nedim Cekmen, Mustafa Arslan, Ozgur Ozsoylar, Aysegul Z. Kordan, Mehmet Akcabay
Saudi Medical Journal May 2006, 27 (5) 646-651;
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© 2025 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

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