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Research ArticleOriginal Article
Open Access

Plasma homocysteine levels and Vitamin B status in patients with Pseudoexfoliation syndrome

M. Sinan Saricaoglu, Ahmet Karakurt, Ahmet Sengun and Hikmet Hasiripi
Saudi Medical Journal June 2006, 27 (6) 833-837;
M. Sinan Saricaoglu
Third Eye Clinic, Ankara Numune Training ana Research Hospital, Sihhiye, Ankara, Turkey. Tel. +90 (312) 4264711. Fax. +90 (312) 4264712. E-mail: [email protected]
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Ahmet Karakurt
Third Eye Clinic, Ankara Numune Training and Research Hospital, Ankara, Turkey.
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Ahmet Sengun
Third Eye Clinic, Ankara Numune Training and Research Hospital, Ankara, Turkey.
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Hikmet Hasiripi
Third Eye Clinic, Ankara Numune Training and Research Hospital, Ankara, Turkey.
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Abstract

OBJECTIVE: To determine and compare the plasma levels of homocysteine and vitamin B (B6, B12 and folate) in patients with Pseudoexfoliation syndrome (PEXS), pseudoexfoliation glaucoma (PEXG), retinal vein occlusion with pseudoexfoliation (PEX+RVO) and in normal individuals.

METHODS: The current study was conducted in the Third Eye Clinic, Ankara Numune Training and Research Hospital, Turkey, between August 2004 and February 2005. Twenty cases with PEXS (Group 1), 20 cases with PEXG (Group 2), 16 cases with PEX+RVO (central or branch retinal vein occlusion) (Group 3) and 20 normal individuals (control group) were included in the study. Those who use vitamin supplements or drugs affecting the plasma homocysteine levels were excluded from the study.

RESULTS: Plasma homocysteine levels were 17.6±4.4 mmol/l in Group 1, 18.5±4.5 mmol/l in Group 2, 22.2±6.0 mmol/l in Group 3, and 14.0±3.1 mmol/l in the control group. It was highest in Group 3 (p<0.001). The ratio of hyperhomocysteinemia was calculated as 35% (Group 1), 45% (Group 2), 68.7% (Groups 3) and 15% (control). These values were statistically higher in the groups with PEXS than in the control group (p=0.009). We did not find any statistically significant difference between the groups with respect to the levels of vitamin B6 and B12 (p>0.05), but the level of folate was lowest in Group 3 (p<0.001).

CONCLUSION: Hyperhomocysteinemia is a risk factor for thromboembolic vasculopathy in patients with PEXS and PEXG. Therefore, vitamin B supplementation should be considered in these patients when hyperhomocysteinemia is detected.

  • Copyright: © Saudi Medical Journal

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Saudi Medical Journal: 27 (6)
Saudi Medical Journal
Vol. 27, Issue 6
1 Jun 2006
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Plasma homocysteine levels and Vitamin B status in patients with Pseudoexfoliation syndrome
M. Sinan Saricaoglu, Ahmet Karakurt, Ahmet Sengun, Hikmet Hasiripi
Saudi Medical Journal Jun 2006, 27 (6) 833-837;

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Plasma homocysteine levels and Vitamin B status in patients with Pseudoexfoliation syndrome
M. Sinan Saricaoglu, Ahmet Karakurt, Ahmet Sengun, Hikmet Hasiripi
Saudi Medical Journal Jun 2006, 27 (6) 833-837;
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© 2023 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

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