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Research ArticleOriginal Article
Open Access

Venous occlusion with lidocaine for preventing propofol induced pain. A prospective double-blind randomized study

Islam M. Massad, Hamdi M. Abu-Ali, Sami A. Abu-Halaweh and Izdiad Z. Badran
Saudi Medical Journal July 2006, 27 (7) 997-1000;
Islam M. Massad
Department of General Surgery, Division of Anesthesia and Intensive Care, Jordan University Hospital, PO Box 13046, Amman 11942, Jordan. Tel.+962 (6) 5353666 Ext 2420. E-mail. [email protected]
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  • For correspondence: [email protected]
Hamdi M. Abu-Ali
Department of General Surgery, Division of Anesthesia and Intensive Care, Faculty of Medicine, Jordan University Hospital, Amman, Jordan.
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Sami A. Abu-Halaweh
Department of General Surgery, Division of Anesthesia and Intensive Care, Faculty of Medicine, Jordan University Hospital, Amman, Jordan.
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Izdiad Z. Badran
Department of General Surgery, Division of Anesthesia and Intensive Care, Faculty of Medicine, Jordan University Hospital, Amman, Jordan.
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Abstract

OBJECTIVE: Pain is a well-known complication of intravenous administration of propofol, and to find out the optimal method to decrease this pain, we studied 4 methods of delivering propofol.

METHODS: The study took place at Jordan University Hospital, Amman, Jordan between November 2004 and March 2005 on 200 patients. The patients were divided into 4 groups, group I (n=50), the control group, propofol 1% was given alone. Group II (n=50), patients received propofol 1% premixed with 40 mg of lidocaine. Group III (n=50), patients received propofol 1% 60 seconds after giving 40 mg of lidocaine. Group IV (n=50), patients had venous occlusion for 60 seconds with the use of lidocaine 1% (40 mg), followed by release of the occlusion and administration of the propofol. Pain was assessed during injection and categorized into: no pain, pain, and pain with behavioral changes.

RESULTS: In group I (control), 35 patient complained of pain, compared to 26 in group II, 23 in group III, and 7 patients in group IV, with a significant reduction in the incidence and intensity of pain in group II, III, and IV compared with the control (p<0.005). The best reduction of intensity and incidence was achieved in group VI, when compared with groups I, II and III (p<0.005), with no statistical difference between group II and III when compared with each other.

CONCLUSION: Of the 4 methods studied, the optimal method to decrease the incidence and intensity of pain resulting from propofol injection is to inject lidocaine while applying venous occlusion for 60 seconds prior to administering propofol.

  • Copyright: © Saudi Medical Journal

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Saudi Medical Journal: 27 (7)
Saudi Medical Journal
Vol. 27, Issue 7
1 Jul 2006
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Venous occlusion with lidocaine for preventing propofol induced pain. A prospective double-blind randomized study
Islam M. Massad, Hamdi M. Abu-Ali, Sami A. Abu-Halaweh, Izdiad Z. Badran
Saudi Medical Journal Jul 2006, 27 (7) 997-1000;

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Venous occlusion with lidocaine for preventing propofol induced pain. A prospective double-blind randomized study
Islam M. Massad, Hamdi M. Abu-Ali, Sami A. Abu-Halaweh, Izdiad Z. Badran
Saudi Medical Journal Jul 2006, 27 (7) 997-1000;
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© 2025 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

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