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Research ArticleOriginal Article
Open Access

Lack of evidence of Epstein-Barr virus infection in patients with Castleman's disease. Molecular genetic analysis

Jaudah Al-Maghrabi, Suzanne Kamel-Reid and Denis J. Bailey
Saudi Medical Journal August 2006, 27 (8) 1125-1129;
Jaudah Al-Maghrabi
Department of Pathology, King Faisal Specialist Hospital & Research Centre, Jeddah, PO Box 40047, Jeddah 21499, MBC J-10, Kingdom of Saudi Arabia. Tel. +966 (2) 6677777 Ext. 7573. Fax. +966 (2) 6632611. E-mail: [email protected]/[email protected]
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  • For correspondence: [email protected] [email protected]
Suzanne Kamel-Reid
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada.
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Denis J. Bailey
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada.
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Abstract

OBJECTIVE: Epstein-Barr virus (EBV) infection is associated with a diverse group of malignancies and many lymphoproliferative disorders. Castleman's disease (CD) is atypical lymphoproliferative disorder. The role of EBV in the pathogenesis of CD is not clear yet. The objective of this study is to investigate the EBV status in CD.

METHODS: We searched medical records for cases of CD at the Toronto General Hospital, Toronto, Canada and King Abdulaziz University Hospital, Jeddah, Saudi Arabia. Twenty cases were found. The presence of EBV was analyzed using polymerase chain reaction. Polymerase chain reaction were performed at the Department of Pathology and Laboratory Medicine, Toronto General Hospital. The study started in 2001 and completed in 2005.

RESULTS: The age range was 16-90 years. Seventeen patients manifested the localized form of CD. There were 11 males 9 females. Epstein-Barr virus genome was detected only in 2 cases; both were males and have plasma cell type. One is a localized type and the other is of a multicentric type. One patient revealed clonal rearrangement of the immunoglobulin H.

CONCLUSION: The number of cases is small; however it appears that EBV is less likely to play a significant role in the pathogenesis of CD; however, it seems to be associated with clonal progression.

  • Copyright: © Saudi Medical Journal

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Saudi Medical Journal: 27 (8)
Saudi Medical Journal
Vol. 27, Issue 8
1 Aug 2006
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Lack of evidence of Epstein-Barr virus infection in patients with Castleman's disease. Molecular genetic analysis
Jaudah Al-Maghrabi, Suzanne Kamel-Reid, Denis J. Bailey
Saudi Medical Journal Aug 2006, 27 (8) 1125-1129;

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Lack of evidence of Epstein-Barr virus infection in patients with Castleman's disease. Molecular genetic analysis
Jaudah Al-Maghrabi, Suzanne Kamel-Reid, Denis J. Bailey
Saudi Medical Journal Aug 2006, 27 (8) 1125-1129;
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© 2023 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

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