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Research ArticleOriginal Article
Open Access

In vitro and in vivo therapeutic activity of ibuprofen against dermatophytes

Ali S. Al-Janabi
Saudi Medical Journal May 2009, 30 (5) 624-628;
Ali S. Al-Janabi
Department of Clinical Laboratory, College of Pharmacy, University of Kerbala, Iraq. Tel. +96 7811411260. E-mail: [email protected]
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Abstract

OBJECTIVE: To evaluate the in vitro and in vivo therapeutic activity of ibuprofen against dermatophytes.

METHODS: The period of study ranged from June to September 2008. For in vitro investigation of ibuprofen activity, measurement of colony diameter, and dry weight were employed against 4 isolated strains of dermatophytes from 46 patients (30-43 years) suffering from dermatophytoses at Morgan Hospital, Hilla City, Iraq in June 2008. For the in vivo evaluation of ibuprofen, rabbits as the main subjects, were infected with dermatophytes and treated with prepared ibuprofen cream (15mg/gm).

RESULTS: In vitro application of ibuprofen showed cidal activity on 4 strains of dermatophytes at minimum inhibitory concentrations of 200 ug/ml. The infected rabbits were successfully cured of dermatophytoses after treatment with ibuprofen cream.

CONCLUSION: Based on in vitro and in vivo application, Ibuprofen can be used as a short-term cure for dermatophytoses.

  • Copyright: © Saudi Medical Journal

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Saudi Medical Journal: 30 (5)
Saudi Medical Journal
Vol. 30, Issue 5
1 May 2009
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In vitro and in vivo therapeutic activity of ibuprofen against dermatophytes
Ali S. Al-Janabi
Saudi Medical Journal May 2009, 30 (5) 624-628;

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In vitro and in vivo therapeutic activity of ibuprofen against dermatophytes
Ali S. Al-Janabi
Saudi Medical Journal May 2009, 30 (5) 624-628;
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© 2025 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

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