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Research ArticleOriginal Article
Open Access

Hypericum perforatum extracts healed gastric lesions induced by hypothermic restraint stress in Wistar rats

Muhammet K. Cayci and Hayri Dayioglu
Saudi Medical Journal June 2009, 30 (6) 750-754;
Muhammet K. Cayci
Department of Biology, Faculty of Science and Arts, Dumlupinar University, Merkez KampusTavsanli Yolu 10 Km 43270, Kutahya, Turkey. Tel. + 90 (274) 2652031 Ext. 3166. Fax. + 90 (274) 2652056. E-mail: [email protected] / [email protected]
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Hayri Dayioglu
Department of Biology, Faculty of Science and Arts, Dumlupinar University, Kutahya, Turkey.
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Abstract

OBJECTIVE: To investigate the healing effects of Hypericum perforatum (HP) on gastric mucosal damage induced by hypothermic restraint stress (HRS.

METHODS: Sixty Wistar breed rats of 200-250 gm were used in this study carried out at the Biology Department of Dumlupinar University, Kutahya, Turkey in 2006. The animals were divided into 6 groups, 2 of which were controls. The HRS were induced by strapping the rats on a wooden plank and keeping them for 3 hours at 4 degrees Celsius after a starvation period of 36 hours. After HRS, 25, 50, and 100 mg/kg/day Hypericum perforatum extracts (HPEs) were orally administrated to the 3 groups during the 3-day treatment. Fifty mg/kg ranitidine was administered everyday as subcutaneous injection to a group selected as a positive control. At the end of treatment, lesions in the stomach were evaluated macroscopically and microscopically.

RESULTS: Macroscopic analyses showed that treatment with HPEs 25, 50, and 100 mg/kg/day significantly healed lesions compared to control groups by 65, 95, and 75% (p=0.001). Treatment with ranitidine also healed ulcers significantly compared with the control groups. Histopathologic analyses indicated that 50 mg/kg/day HP produced the most significant effect.

CONCLUSION: Moderate doses of HP produced significant healing of HRS induced gastric ulcer in rats. The present study indicated that HPEs have therapeutic potential for the control of ulcers. Moderate doses of HP produced significant healing of HRS induced gastric ulcer in rats. The present study indicated that HPEs have therapeutic potential for the control of ulcers.

  • Copyright: © Saudi Medical Journal

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Saudi Medical Journal: 30 (6)
Saudi Medical Journal
Vol. 30, Issue 6
1 Jun 2009
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Hypericum perforatum extracts healed gastric lesions induced by hypothermic restraint stress in Wistar rats
Muhammet K. Cayci, Hayri Dayioglu
Saudi Medical Journal Jun 2009, 30 (6) 750-754;

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Hypericum perforatum extracts healed gastric lesions induced by hypothermic restraint stress in Wistar rats
Muhammet K. Cayci, Hayri Dayioglu
Saudi Medical Journal Jun 2009, 30 (6) 750-754;
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© 2025 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

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