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Research ArticleOriginal Article
Open Access

Role of biopsy in pediatric lymphadenopathy

Ghazala Hanif, Shahid I Ali, Anum Shahid, Fakeha Rehman and Uzma Mirza
Saudi Medical Journal June 2009, 30 (6) 798-802;
Ghazala Hanif
Department of Pathology, The Children's Hospital and The Institute of Child Health, 41-B,Staff Colony, Allama Iqbal Medical College, Lahore, Pakistan. Tel. +92 (042) 5167533. E-mail: [email protected]
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Shahid I Ali
Department of Pathology, The Children's Hospital and The Institute of Child Health, 41-B,Staff Colony, Allama Iqbal Medical College, Lahore, Pakistan. Tel. +92 (042) 5167533. E-mail: [email protected]
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Anum Shahid
Department of Pathology, The Children's Hospital and The Institute of Child Health, 41-B,Staff Colony, Allama Iqbal Medical College, Lahore, Pakistan. Tel. +92 (042) 5167533. E-mail: [email protected]
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Fakeha Rehman
Department of Pathology, The Children's Hospital and The Institute of Child Health, 41-B,Staff Colony, Allama Iqbal Medical College, Lahore, Pakistan. Tel. +92 (042) 5167533. E-mail: drghazalahan[email protected]
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Uzma Mirza
Department of Pathology, The Children's Hospital and The Institute of Child Health, 41-B,Staff Colony, Allama Iqbal Medical College, Lahore, Pakistan. Tel. +92 (042) 5167533. E-mail: [email protected]
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Abstract

OBJECTIVE: To determine the role of lymph node biopsy in the diagnosis of lymphadenopathy and to find out the pattern of different diseases in relation to age, gender, and the site of lymph nodes involved.

METHODS: This retrospective study was carried out at the Histopathology Department of the Children's Hospital and The Institute of Child Health, Lahore, Pakistan, over a period of 9 years, from January 1999 to December 2007. Tissue samples were collected from 898 children presenting with lymphadenopathy, and the diagnosis was confirmed on histology and through various specific tests. The clinical data of the patients were collected from computerized hospital records.

RESULTS: Among the total 898 consecutive lymph node biopsies, the most common pathology encountered was reactive hyperplasia in 356 children (39.6%), followed by tuberculosis in 262 (29.1%) and malignant lymphomas in 132 children (14.6%). The rest of the lesions include; 72 cases of granulomatous lymphadenitis (8%), 13 of histiocytosis X (1.4%), 44 (4.9%) of metastatic tumors, 16 of chronic inflammation (1.8%), and 3 cases of Kikuchi's disease (0.3%). The cause of lymphadenopathy was found to be significantly associated with age, gender, and site of the lymph nodes involved.

CONCLUSION: Lymphadenopathy is a relatively common condition in the pediatric age group. Although 39.6% of children had reactive hyperplasia of unknown etiology, 60.3% children presented with a specific diagnosis. Lymphadenopathy is a relatively common condition in the pediatric age group. Although 39.6% of children had reactive hyperplasia of unknown etiology, 60.3% children presented with a specific diagnosis.

  • Copyright: © Saudi Medical Journal

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Saudi Medical Journal: 30 (6)
Saudi Medical Journal
Vol. 30, Issue 6
1 Jun 2009
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Role of biopsy in pediatric lymphadenopathy
Ghazala Hanif, Shahid I Ali, Anum Shahid, Fakeha Rehman, Uzma Mirza
Saudi Medical Journal Jun 2009, 30 (6) 798-802;

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Role of biopsy in pediatric lymphadenopathy
Ghazala Hanif, Shahid I Ali, Anum Shahid, Fakeha Rehman, Uzma Mirza
Saudi Medical Journal Jun 2009, 30 (6) 798-802;
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© 2023 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

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