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Research ArticleOriginal Article
Open Access

Association between glucose variability and adverse in-hospital outcomes for Chinese patients with acute coronary syndrome

Xue-Lian Zhang, Ju-Ming Lu, Guang-Liang Shan, Zhao-Jun Yang and Wen-Ying Yang
Saudi Medical Journal October 2010, 31 (10) 1146-1151;
Xue-Lian Zhang
Department of Endocrinology, China-Japan Friendship Hospital, Chinese PLA General Hospital, Beijing, China.
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Ju-Ming Lu
Department of Endocrinology, China-Japan Friendship Hospital, Chinese PLA General Hospital, Beijing, China.
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Guang-Liang Shan
Department of Endocrinology, China-Japan Friendship Hospital, Chinese PLA General Hospital, Beijing, China.
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Zhao-Jun Yang
Department of Endocrinology, China-Japan Friendship Hospital, Chinese PLA General Hospital, Beijing, China.
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Wen-Ying Yang
Department of Endocrinology, China-Japan Friendship Hospital, Chinese PLA General Hospital, Beijing, China.
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Abstract

OBJECTIVE: To investigate the association between mean blood glucose (MBG) and glucose variability (GV) during hospitalization, and adverse in-hospital outcomes for patients with acute coronary syndrome (ACS).

METHODS: This is a retrospective cohort study and conducted in 2 tertiary hospitals in Beijing, China. All data were collected from the medical records concerning ACS patients admitted to the hospital between January 2003 to December 2006. Hyperglycemia was related to clinical outcomes (including major adverse cardiovascular events [MACEs] and in-hospital death) using coefficient of variation of blood glucose (GluCV) or mean blood glucose (MBG). Total cohort was stratified by GluCV or MBG quartiles. Diabetic and non-diabetic subgroups were then separately analyzed. Multivariate logistic regression analysis was performed to evaluate the independent risk factor of in-hospital death.

RESULTS: A total of 1756 cases were enrolled in this study. For total cohort or non-diabetic cohort, prevalence of adverse outcomes was higher in patients with higher MBG or GluCV (p for trend <0.001). For diabetic ACS patients, MACEs were found more common in MBG or GluCV quartiles (p for trend <0.001), in-hospital mortality increased across MBG (p for trend <0.001), or GluCV quartiles (p for trend=0.004). Multivariate logistic regression analysis showed that GluCV (odds ratio: 1.29) was a stronger predictor of in-hospital death than MBG (odds ratios: 1.20).

CONCLUSION: The GluCV is a better discriminator of in-hospital mortality than MBG in ACS patients.

  • Copyright: © Saudi Medical Journal

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Saudi Medical Journal: 31 (10)
Saudi Medical Journal
Vol. 31, Issue 10
1 Oct 2010
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Association between glucose variability and adverse in-hospital outcomes for Chinese patients with acute coronary syndrome
Xue-Lian Zhang, Ju-Ming Lu, Guang-Liang Shan, Zhao-Jun Yang, Wen-Ying Yang
Saudi Medical Journal Oct 2010, 31 (10) 1146-1151;

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Association between glucose variability and adverse in-hospital outcomes for Chinese patients with acute coronary syndrome
Xue-Lian Zhang, Ju-Ming Lu, Guang-Liang Shan, Zhao-Jun Yang, Wen-Ying Yang
Saudi Medical Journal Oct 2010, 31 (10) 1146-1151;
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© 2025 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

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