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Research ArticleOriginal Article
Open Access

Pretreatment with stellate ganglion blockade before ischemia reduces infarct size in rat hearts

Nebahat Gulcu-Bulut, Ersoz Gonca, Hasan Kocoglu, Omer Bozdogan and Kazim Karaaslan
Saudi Medical Journal February 2010, 31 (2) 148-152;
Nebahat Gulcu-Bulut
Department of Anesthesiology, Medical Faculty, Abant Izzet Baysal University, Bolu 14280, Turkey. Tel. +90 (374) 2534656/3123. Fax. +90 (374) 2534616. E-mail: [email protected]
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Ersoz Gonca
Department of Anesthesiology, Medical Faculty, Abant Izzet Baysal University, Bolu 14280, Turkey. Tel. +90 (374) 2534656/3123. Fax. +90 (374) 2534616. E-mail: [email protected]
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Hasan Kocoglu
Department of Anesthesiology, Medical Faculty, Abant Izzet Baysal University, Bolu 14280, Turkey. Tel. +90 (374) 2534656/3123. Fax. +90 (374) 2534616. E-mail: [email protected]
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Omer Bozdogan
Department of Anesthesiology, Medical Faculty, Abant Izzet Baysal University, Bolu 14280, Turkey. Tel. +90 (374) 2534656/3123. Fax. +90 (374) 2534616. E-mail: [email protected]
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Kazim Karaaslan
Department of Anesthesiology, Medical Faculty, Abant Izzet Baysal University, Bolu 14280, Turkey. Tel. +90 (374) 2534656/3123. Fax. +90 (374) 2534616. E-mail: [email protected]
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Abstract

OBJECTIVE: To investigate the role of stellate ganglion blockade (SGB) in cardio-protection against ischemia reperfusion injury.

METHODS: This prospective randomized, experimental study was carried out between August and October 2008 in the Department of Anesthesia, Abant Izzet Baysal University, Bolu, Turkey. Twenty-one rats were randomly divided into 3 groups; group 1 - SGB group (rats with percutaneous ganglion blockade), group 2 - preconditioned (P) group (rats that were subjected to ischemia and then reperfusion periods for 5 minutes), and group 3 - control group (rats that were injected with normal saline).

RESULTS: During the ligation period, the length of arrhythmia was significantly shorter in group 2 compared with group 3 (p<0.001). The arrhythmia score in groups 1 and 2 was significantly lower compared with group 3 (p<0.001). In the reperfusion period, the length of arrhythmia was not significantly different in all study groups (p>0.05). But the arrhythmia score was significantly lower both in group 1 and group 3, compared with group 2 (p<0.02). Both in the ischemic and reperfusion periods, the incidence of arrhythmia was lowest in group 1. The infarct size was measured significantly less in groups 1 and 2 compared with group 3 (p<0.001).

CONCLUSION: Pretreatment with the left SGB leads to lower arrhythmia scores and reduced infarct size in the Langendorff-perfused rat hearts compared with group 3, but not with group 2.

  • Copyright: © Saudi Medical Journal

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial License (CC BY-NC), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Saudi Medical Journal: 31 (2)
Saudi Medical Journal
Vol. 31, Issue 2
1 Feb 2010
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Pretreatment with stellate ganglion blockade before ischemia reduces infarct size in rat hearts
Nebahat Gulcu-Bulut, Ersoz Gonca, Hasan Kocoglu, Omer Bozdogan, Kazim Karaaslan
Saudi Medical Journal Feb 2010, 31 (2) 148-152;

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Pretreatment with stellate ganglion blockade before ischemia reduces infarct size in rat hearts
Nebahat Gulcu-Bulut, Ersoz Gonca, Hasan Kocoglu, Omer Bozdogan, Kazim Karaaslan
Saudi Medical Journal Feb 2010, 31 (2) 148-152;
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© 2025 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

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