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Research ArticleOriginal Article
Open Access

Expression of transforming growth factor-beta 1 and connective tissue growth factor in women with pelvic organ prolapse.

Xiao-Ying Qi, Li Hong, Feng-Qin Guo, Qiong Fu, Lu Chen and Bing-Shu Li
Saudi Medical Journal May 2011, 32 (5) 474-478;
Xiao-Ying Qi
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Li Hong
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Feng-Qin Guo
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Qiong Fu
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Lu Chen
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Bing-Shu Li
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Abstract

OBJECTIVES: To investigate the presence of transforming growth factor-beta 1 (TGF-ß1) and connective tissue growth factor (CTGF) in women with pelvic organ prolapse (POP).

METHODS: This study was conducted from May to December 2009. Fifty patients with POP that underwent vaginal hysterectomy in the Department of Gynecology, Renmin Hospital of Wuhan University, Hubei, Wuhan, China were enrolled in this study. They were divided into: Group 1 (n=10); Group 2 (n=10); and Group 3 (n=10) according to Pelvic Organ Prolapse Quantitation (POP-Q). Meanwhile, 20 cases treated by vaginal hysterectomy for other benign gynecological diseases were selected as the control group. Immunohistochemical staining and Western blot were performed to detect the expression of TGF-ß1 and CTGF.

RESULTS: Immunohistochemical staining of TGF-ß1 and CTGF were mainly expressed in the cytoplasm of fibroblast cells. The expression of TGF-ß1 and CTGF protein was significantly negatively correlated with POP-Q stage. There were significantly positive correlations between the expression of TGF-ß1 and CTGF protein. The expression of TGF-ß1 protein among the 3 POP groups were all significantly lower than that of the control group, while there was no significant differences in the expression of TGF-ß1 protein among the POP groups, excluding the comparison between Groups 1 and 3. The expression of CTGF protein in the 3 POP groups were all significantly lower than that of the control group, and significant differences were also detected among the 3 POP groups.

CONCLUSIONS: In this study, we found that the TGF-ß1 and CTGF protein expression may be associated with POP, especially in POP-Q stages.

  • Copyright: © Saudi Medical Journal

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Saudi Medical Journal: 32 (5)
Saudi Medical Journal
Vol. 32, Issue 5
1 May 2011
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Expression of transforming growth factor-beta 1 and connective tissue growth factor in women with pelvic organ prolapse.
Xiao-Ying Qi, Li Hong, Feng-Qin Guo, Qiong Fu, Lu Chen, Bing-Shu Li
Saudi Medical Journal May 2011, 32 (5) 474-478;

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Expression of transforming growth factor-beta 1 and connective tissue growth factor in women with pelvic organ prolapse.
Xiao-Ying Qi, Li Hong, Feng-Qin Guo, Qiong Fu, Lu Chen, Bing-Shu Li
Saudi Medical Journal May 2011, 32 (5) 474-478;
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© 2025 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

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