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Research ArticleOriginal Article
Open Access

Misoprostol for induction of labor in women with severe preeclampsia at or near term.

Kaima A. Frass, Alia A. Shuaib and Abdelrahman H. Al-Harazi
Saudi Medical Journal July 2011, 32 (7) 679-684;
Kaima A. Frass
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Alia A. Shuaib
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Abdelrahman H. Al-Harazi
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Abstract

OBJECTIVES: To examine the misoprostol efficacy and safety in induction of labor of women with severe preeclampsia at or near term when the cervix is unfavorable.

METHODS: A prospective comparative study was conducted in Al-Thawara General Hospital Sana'a , Yemen, from June 2009 to June 2010. One hundred and thirteen women met the inclusion criteria. They were divided into 2 groups. The study group (n = 56) and the control group (n = 57). The study group were given 50 µg of Misoprostol intravaginally every 4 hours to a maximum of 6 doses. Maternal age, gestational age, parity, initial cervical status, the rate of cesarean section, and neonatal outcomes were analyzed and compared to the control group.

RESULTS: The vaginal delivery was achieved in 69.6% in the study group versus 15.8% in the control group (p < 0.0001). The overall cesarean section was performed in 30.3% of the study group versus 84.2% (p < 0.0001). The mean time from insertion to delivery was 12.12 ± 2.1 hours and the mean dosing was 2.77±1.3. There were no significant differences between the 2 groups in the frequency of abnormal fetal heart rate, Apgar score and admission to the neonatal intensive care unit.

CONCLUSIONS: Misoprostol when given intravaginally in 50 mcg 4-hourly dosing regimen is an effective agent for ripening the cervix in this group of women.

  • Copyright: © Saudi Medical Journal

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Saudi Medical Journal: 32 (7)
Saudi Medical Journal
Vol. 32, Issue 7
1 Jul 2011
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Misoprostol for induction of labor in women with severe preeclampsia at or near term.
Kaima A. Frass, Alia A. Shuaib, Abdelrahman H. Al-Harazi
Saudi Medical Journal Jul 2011, 32 (7) 679-684;

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Misoprostol for induction of labor in women with severe preeclampsia at or near term.
Kaima A. Frass, Alia A. Shuaib, Abdelrahman H. Al-Harazi
Saudi Medical Journal Jul 2011, 32 (7) 679-684;
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© 2025 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

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