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Research ArticleOriginal Article
Open Access

In-hospital adverse clinical outcomes of ST elevation myocardial infarction patients with renal dysfunction. Insights from the Saudi Project for Assessment of Coronary Events.

Hussam F. Al Faleh, Abdulkareem O. AlSuwaida, Ahmad S. Hersi, Anhar Ullah, Ali M. AlShahrani, Khalid A. Al-Nemer, Shukri M. Al-Saif, Amir M. Taraben, Tarek S. Kashour, Waqar H. Ahmed, Mohammed A. Balghith and Khalid F. Al-Habib
Saudi Medical Journal August 2011, 32 (8) 806-812;
Hussam F. Al Faleh
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Abdulkareem O. AlSuwaida
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Ahmad S. Hersi
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Anhar Ullah
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Ali M. AlShahrani
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Khalid A. Al-Nemer
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Shukri M. Al-Saif
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Amir M. Taraben
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Tarek S. Kashour
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Waqar H. Ahmed
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Mohammed A. Balghith
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Khalid F. Al-Habib
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Abstract

OBJECTIVES: To explore the prognostic value of baseline estimated glomerular filtration rate (eGFR) in Saudi patients presenting with ST elevation myocardial infarction (STEMI), and its impact on hospital therapies.

METHODS: The STEMI patients with a baseline serum Creatinine enrolled in the SPACE (Saudi Project for Assessment of Coronary Events) registry were analyzed. This study was performed in several regions in Saudi Arabia between December 2005 to December 2007. Based on eGFR levels, patients were classified into: more than 90.1 ml/min (normal renal function), 90-60.1 (borderline/mildly impaired renal function), 60-30 (moderate renal dysfunction), and less than 30 ml/min/1.73 m2 (severe renal dysfunction).

RESULTS: Two thousand and fifty-eight patients qualified for this study. Of these, 1058 patients had renal dysfunction. Patients with renal dysfunction were older, and had a higher prevalence of risk factors for atherosclerosis. Patients with moderate or severe renal dysfunction were less likely to be treated with beta blockers, angiotensin converting enzymes inhibitors, statins, or reperfusion therapies. Significantly worse outcomes were seen with lower eGFR in a stepwise fashion. The adjusted odds ratio of in-hospital death in patients with eGFR less than 30 ml/min was 5.3 (95% CI, 1.15-25.51, p=0.0383).

CONCLUSIONS: A low baseline eGFR in STEMI patients is an independent predictor of all major adverse cardiovascular outcomes, and a marker for less aggressive in-hospital therapy.

  • Copyright: © Saudi Medical Journal

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Saudi Medical Journal: 32 (8)
Saudi Medical Journal
Vol. 32, Issue 8
1 Aug 2011
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In-hospital adverse clinical outcomes of ST elevation myocardial infarction patients with renal dysfunction. Insights from the Saudi Project for Assessment of Coronary Events.
Hussam F. Al Faleh, Abdulkareem O. AlSuwaida, Ahmad S. Hersi, Anhar Ullah, Ali M. AlShahrani, Khalid A. Al-Nemer, Shukri M. Al-Saif, Amir M. Taraben, Tarek S. Kashour, Waqar H. Ahmed, Mohammed A. Balghith, Khalid F. Al-Habib
Saudi Medical Journal Aug 2011, 32 (8) 806-812;

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In-hospital adverse clinical outcomes of ST elevation myocardial infarction patients with renal dysfunction. Insights from the Saudi Project for Assessment of Coronary Events.
Hussam F. Al Faleh, Abdulkareem O. AlSuwaida, Ahmad S. Hersi, Anhar Ullah, Ali M. AlShahrani, Khalid A. Al-Nemer, Shukri M. Al-Saif, Amir M. Taraben, Tarek S. Kashour, Waqar H. Ahmed, Mohammed A. Balghith, Khalid F. Al-Habib
Saudi Medical Journal Aug 2011, 32 (8) 806-812;
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© 2025 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

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