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Research ArticleOriginal Article
Open Access

Effect of acrylamide on testis of albino rats. Ultrastructure and DNA cytometry study

Hesham N. Mustafa
Saudi Medical Journal July 2012, 33 (7) 722-731;
Hesham N. Mustafa
Department of Anatomy, Faculty of Medicine, King Abdulaziz University, PO Box 80205, Jeddah 21589, Kingdom of Saudi Arabia. Tel. +966 566764762. E-mail: [email protected]
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Abstract

OBJECTIVE: To explore the harmful effects of acrylamide on the structure of testis in albino rats, in an attempt to clarify its potential risks on human health.

METHODS: The present study was carried out in the Department of Anatomy, Faculty of Medicine, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia from December 2010 to December 2011. Forty-eight adult male albino rats (250-300 g) were divided randomly into 6 groups. Electron microscopy and histochemical techniques using Feulgen stain were used to conduct the morphological study. In addition, DNA cytometry method was used.

RESULTS: Rats treated with acrylamide 25 mg/kg body weight for 10 days showed mild affection, whether acrylamide was administered orally or intraperitoneally. On the other hand, the testis of the group treated with a dose of 50 mg/kg/10 days showed damage, especially with intraperitoneal administration in comparison to oral treatment. This was in the form of degeneration of germ cells, numerous multinucleated giant cells with sloughed seminiferous epithelium, and vacuolation in-between the germ cells.

CONCLUSION: Exposure to acrylamide produced degenerative changes in the testis, which were more prominent with a longer period of exposure. Recommendations are necessary to decrease acrylamide level in different foods, and ways to decrease acrylamide formation during preparation of different foods should be advertised.

  • Copyright: © Saudi Medical Journal

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial License (CC BY-NC), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Saudi Medical Journal: 33 (7)
Saudi Medical Journal
Vol. 33, Issue 7
1 Jul 2012
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Effect of acrylamide on testis of albino rats. Ultrastructure and DNA cytometry study
Hesham N. Mustafa
Saudi Medical Journal Jul 2012, 33 (7) 722-731;

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Effect of acrylamide on testis of albino rats. Ultrastructure and DNA cytometry study
Hesham N. Mustafa
Saudi Medical Journal Jul 2012, 33 (7) 722-731;
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© 2025 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

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