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Research ArticleOriginal Article
Open Access

Role of vitamins E and C in mitigating hypoxia- and exhaustive exercise-induced aberrant stem cell factor expression and impaired reproductive function in male Wistar rats

Fahaid H. Al-Hashem
Saudi Medical Journal April 2013, 34 (4) 354-363;
Fahaid H. Al-Hashem
Department of Physiology, College of Medicine, King Khalid University, Abha 61421, Kingdom of Saudi Arabia. Fax. +966 (7) 2418364. E-mail: [email protected]
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Abstract

OBJECTIVE: To evaluate and compare the potential role of vitamins E and C in protecting against acute swimming induced reproductive function damage at different altitudes.

METHODS: The study was carried between October and November 2010. A total of 36 adult male Wistar rats weighing 250+/-5 g, and aged 8 weeks were used in this study, which was carried at the Physiology laboratory of King Khalid University in Abha City (high altitude area [HA]), and at the College of Science, King Saud University in Riyadh city (low altitude area [LA]), Kingdom of Saudi Arabia. The rats of each area were divided into 3 groups (n=6 each): control, acute exercise stress, and vitamins E and C pretreated stress. At the end of the study, oxidative stress, reproductive function, histopathology, and expression of stem cell factor (CSF) were examined in all rats.

RESULTS: Living under HA conditions decreased expression of SCF, sperm count, and serum levels of reproductive hormones, and significantly increased testicle tissue oxidative stress and lipid peroxidation. Exhaustive exercise-induced stress at both altitudes resulted in similar results with more deteriorating effects in rats of HA compared with LA. Supplementation of vitamins E and C prior to stress induction at both altitudes prevented all these structural and functional aberrations from happening.

CONCLUSION: High altitude or strenuous exercise, or both, may impair male reproductive function, while vitamins E and C in combination potentially mitigate these adverse effects.

  • Copyright: © Saudi Medical Journal

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial License (CC BY-NC), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Saudi Medical Journal: 34 (4)
Saudi Medical Journal
Vol. 34, Issue 4
1 Apr 2013
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Role of vitamins E and C in mitigating hypoxia- and exhaustive exercise-induced aberrant stem cell factor expression and impaired reproductive function in male Wistar rats
Fahaid H. Al-Hashem
Saudi Medical Journal Apr 2013, 34 (4) 354-363;

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Role of vitamins E and C in mitigating hypoxia- and exhaustive exercise-induced aberrant stem cell factor expression and impaired reproductive function in male Wistar rats
Fahaid H. Al-Hashem
Saudi Medical Journal Apr 2013, 34 (4) 354-363;
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© 2025 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

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