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Research ArticleOriginal Article
Open Access

Modulation of proinflammatory cytokines and leukocyte mobilization by melatonin in response to sterile tissue injury in Wistar albino rats

Hussein F. Sakr and Bahjat Al-Ani
Saudi Medical Journal May 2013, 34 (5) 470-476;
Hussein F. Sakr
Department of Physiology, College of Medicine, King Khalid University, Abha 61421, Kingdom of Saudi Arabia. Tel. +966 540273993. E-mail: [email protected]
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Bahjat Al-Ani
Department of Physiology, College of Medicine, King Khalid University, Abha 61421, Kingdom of Saudi Arabia. Tel. +966 540273993. E-mail: [email protected]
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Abstract

OBJECTIVE: To test the hypothesis that the neurohormone, melatonin, differentially activates the release of the proinflammatory cytokines, such as, interleukin-1 beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha), as well as inducing leukocyte mobilization into the peripheral blood in response to a sterile tissue injury.

METHODS: This study was conducted between November 2011 and September 2012 at the Department of Physiology, College of Medicine, King Khalid University, Abha, Kingdom of Saudi Arabia. Sterile tissue injury of either skin injury or gastric ulceration was induced in equal numbers in Wistar albino rats aged 7-8 weeks (150-200 g) (20 each), with each group being equally divided into melatonin treated or vehicle-treated.

RESULTS: Melatonin treatment and sterile tissue injuries significantly (p<0.05) increased the plasma levels of IL-1beta and TNF-alpha compared to baseline levels. However, higher levels of IL-1beta compared with TNF-alpha were obtained only with melatonin treatment. Furthermore, melatonin treatment significantly increased (p<0.05) total leukocyte counts before the induction of skin injury and gastric ulceration, and remained elevated for a longer period than injured, but vehicle-treated rats. In addition, our methods of inducing skin injury or gastric ulceration caused an increase in leukocyte levels in the blood circulation (p<0.05).

CONCLUSION: Melatonin differentially stimulated plasma IL-1beta and TNF-alpha, and increased blood leukocyte counts before and after sterile tissue injuries. It is worth pursuing further investigation into the therapeutic effect of melatonin in inflammatory disease that involves leukocyte recruitment to sites of injury.

  • Copyright: © Saudi Medical Journal

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial License (CC BY-NC), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Saudi Medical Journal: 34 (5)
Saudi Medical Journal
Vol. 34, Issue 5
1 May 2013
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Modulation of proinflammatory cytokines and leukocyte mobilization by melatonin in response to sterile tissue injury in Wistar albino rats
Hussein F. Sakr, Bahjat Al-Ani
Saudi Medical Journal May 2013, 34 (5) 470-476;

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Modulation of proinflammatory cytokines and leukocyte mobilization by melatonin in response to sterile tissue injury in Wistar albino rats
Hussein F. Sakr, Bahjat Al-Ani
Saudi Medical Journal May 2013, 34 (5) 470-476;
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© 2025 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

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