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Research ArticleOriginal Article
Open Access

The effect of obesity and periodontitis on the expression of antimicrobial peptides in gingival tissues

Mohammad S. Al-Zahrani, Khalid H. Zawawi and Faris M. Altaf
Saudi Medical Journal May 2013, 34 (5) 525-530;
Mohammad S. Al-Zahrani
Department of Oral Basic and Clinical Sciences, Faculty of Dentistry, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.
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Khalid H. Zawawi
Department of Oral Basic and Clinical Sciences, Faculty of Dentistry, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.
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Faris M. Altaf
Department of Oral Basic and Clinical Sciences, Faculty of Dentistry, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.
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Abstract

OBJECTIVE: To compare the expression of human beta-defensins (HBD) in the gingival tissues of obese and normal weight systemically healthy subjects.

METHODS: This cross-sectional study was conducted at the Faculty of Dentistry, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia from March 2010 to November 2011. Twenty obese (10 affected with periodontitis and 10 periodontally healthy), and 20 normal weight subjects (10 affected with periodontitis and 10 periodontally healthy) were selected. Gingival tissue samples were collected and subjected to immunohistochemistry assay to evaluate the expression of HBD-1 and -2.

RESULTS: In the epithelium, the staining was almost limited to the basal and supra-basal cells, while the superficial layers and keratin were negative. In the connective tissue, some of the chronic inflammatory cells and fibroblasts were also stained. Endothelial cells lining blood or lymphatic vessels were mostly positive with HBD-2 and were almost negative with HBD-1. The percentage of positively stained areas did not show any differences in the expression of HBD-1 and -2 in obese compared to normal weight subjects whether they were affected or not affected with periodontitis.

CONCLUSION: The results of this study did not demonstrate an association between the expression of HBD-1 and -2 and obesity and periodontitis.

  • Copyright: © Saudi Medical Journal

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial License (CC BY-NC), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Saudi Medical Journal: 34 (5)
Saudi Medical Journal
Vol. 34, Issue 5
1 May 2013
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The effect of obesity and periodontitis on the expression of antimicrobial peptides in gingival tissues
Mohammad S. Al-Zahrani, Khalid H. Zawawi, Faris M. Altaf
Saudi Medical Journal May 2013, 34 (5) 525-530;

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The effect of obesity and periodontitis on the expression of antimicrobial peptides in gingival tissues
Mohammad S. Al-Zahrani, Khalid H. Zawawi, Faris M. Altaf
Saudi Medical Journal May 2013, 34 (5) 525-530;
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© 2025 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

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