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Research ArticleOriginal Article
Open Access

Pre-treatment and post-treatment changes in platelet indices in patients with immune thrombocytopenia

Serdal Korkmaz, Ali U. Uslu, Bahattin Aydin, Ozgur Dogan and Mehmet Sencan
Saudi Medical Journal June 2013, 34 (6) 591-596;
Serdal Korkmaz
Department of Hematology, Medical Faculty, Cumhuriyet University, 58140, Sivas, Turkey. Tel. +90 (346) 2580809. Fax: +90 (346) 2581305. E-mail: [email protected]
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Ali U. Uslu
Department of Hematology, Medical Faculty, Cumhuriyet University, 58140, Sivas, Turkey. Tel. +90 (346) 2580809. Fax: +90 (346) 2581305. E-mail: [email protected]
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Bahattin Aydin
Department of Hematology, Medical Faculty, Cumhuriyet University, 58140, Sivas, Turkey. Tel. +90 (346) 2580809. Fax: +90 (346) 2581305. E-mail: [email protected]
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Ozgur Dogan
Department of Hematology, Medical Faculty, Cumhuriyet University, 58140, Sivas, Turkey. Tel. +90 (346) 2580809. Fax: +90 (346) 2581305. E-mail: [email protected]
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Mehmet Sencan
Department of Hematology, Medical Faculty, Cumhuriyet University, 58140, Sivas, Turkey. Tel. +90 (346) 2580809. Fax: +90 (346) 2581305. E-mail: [email protected]
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Abstract

OBJECTIVE: To investigate if there is a correlation between pre- and post-treatment mean platelet volume (MPV), platelet size deviation width (PDW), and platecrit (PCT) values and to investigate whether we can use them as laboratory parameters to estimate the relapses of immune thrombocytopenia (ITP) patients.

METHODS: Patients with ITP diagnosed at the Hematology Clinic, School of Medicine, Cumhuriyet University, Sivas, Turkey between January 2005 and December 2011 were evaluated by a retrospective review of our patients' records. Eighty-one patients with ITP were collected. The first relapse was termed as the hospitalization day before second-line therapy, and the second relapse was termed as the hospitalization day before alternate second-line therapy. We provided the following data of ITP patients at diagnosis, before and after first relapses, and before and after second relapses: presenting symptoms, platelet count, MPV, PDW, and PCT values.

RESULTS: We obtained significant statistical differences between MPV values after initial treatment and before second-line therapy (first relapse) (p=0.005), between MPV values after splenectomy and before immunosuppressive or immune modulator therapy (second relapse) (p=0.028), and also, between PCT values after splenectomy and before second relapse (p=0.043).

CONCLUSION: Mean platelet volume is gradually increasing before first and second relapses, and again normal values are being obtained after appropriate therapies. We conclude that MPV is a useful parameter as a predictor of relapses.

  • Copyright: © Saudi Medical Journal

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial License (CC BY-NC), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Saudi Medical Journal: 34 (6)
Saudi Medical Journal
Vol. 34, Issue 6
1 Jun 2013
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Pre-treatment and post-treatment changes in platelet indices in patients with immune thrombocytopenia
Serdal Korkmaz, Ali U. Uslu, Bahattin Aydin, Ozgur Dogan, Mehmet Sencan
Saudi Medical Journal Jun 2013, 34 (6) 591-596;

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Pre-treatment and post-treatment changes in platelet indices in patients with immune thrombocytopenia
Serdal Korkmaz, Ali U. Uslu, Bahattin Aydin, Ozgur Dogan, Mehmet Sencan
Saudi Medical Journal Jun 2013, 34 (6) 591-596;
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© 2025 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

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