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Research ArticleOriginal Article
Open Access

The role of interleukin-6 promoter polymorphism -174G/C in Saudi women with hypertensive disorders of pregnancy

Nervana M. Bayoumy, Ashwag S. Al-Sharaidh, Zainab H. Babay and Abdulgalil M. Abdulgader
Saudi Medical Journal July 2013, 34 (7) 689-694;
Nervana M. Bayoumy
Physiology Department, College of Medicine, Center of Excellence in Thrombosis & Hemostasis, King Khalid University Hospital, King Saud University, PO Box 2925, Riyadh 11461, Kingdom of Saudi Arabia. Tel. +966 550555217. Fax. +966 (11) 4699147. E-mail: [email protected]
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Ashwag S. Al-Sharaidh
Physiology Department, College of Medicine, Center of Excellence in Thrombosis & Hemostasis, King Khalid University Hospital, King Saud University, PO Box 2925, Riyadh 11461, Kingdom of Saudi Arabia. Tel. +966 550555217. Fax. +966 (11) 4699147. E-mail: [email protected]
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Zainab H. Babay
Physiology Department, College of Medicine, Center of Excellence in Thrombosis & Hemostasis, King Khalid University Hospital, King Saud University, PO Box 2925, Riyadh 11461, Kingdom of Saudi Arabia. Tel. +966 550555217. Fax. +966 (11) 4699147. E-mail: [email protected]
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Abdulgalil M. Abdulgader
Physiology Department, College of Medicine, Center of Excellence in Thrombosis & Hemostasis, King Khalid University Hospital, King Saud University, PO Box 2925, Riyadh 11461, Kingdom of Saudi Arabia. Tel. +966 550555217. Fax. +966 (11) 4699147. E-mail: [email protected]
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Abstract

OBJECTIVE: To study the relationship between -174 GC interleukin-6 single nucleotide polymorphism and hypertensive disorders of pregnancy (HDP) in Saudi women.

METHODS: In this case-control study, 109 HDP patients and 100 women with normal pregnancy as a control group were studied. The HDP study group constituted of 60 women with gestational hypertension (GH) and 49 women with preeclampsia (PE). All women were randomly selected from the antenatal clinic and the prenatal and postnatal wards at the Antenatal Clinic and the Obstetric Ward of King Khalid University Hospital, Riyadh, Kingdom of Saudi Arabia from April 2010 to December 2011. The -174 GC of IL-6 SNP was determined using real time polymerase chain reaction, allele discrimination technique.

RESULTS: Distribution of -174 GC of IL-6 genotype in HDP patients was GG (58.5%), GC (31.1%), and CC (10.4%), while in the control group was GG (67%), GC (30.9%), and CC (2.1%). The CC homozygosity was significantly associated with HDP (odds ratio [OR] = 5.76; 95% confidence interval [CI] 1.23-27.06, p=0.03). This association only manifested with GH (OR = 7.65; 95% CI = 1.54-38.03, p=0.01). However, no significant association was found with PE (OR = 3.48; 95% CI = 0.55-21.99, p=0.19).

CONCLUSION: The results indicate a positive association between -174 GC of IL-6 genotype and the risk of HDP. Genotypes CC and GC are associated with increased risk of GH but not with PE, suggesting that they are of differing genetic predisposition/pathophysiology.

  • Copyright: © Saudi Medical Journal

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial License (CC BY-NC), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Saudi Medical Journal: 34 (7)
Saudi Medical Journal
Vol. 34, Issue 7
1 Jul 2013
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The role of interleukin-6 promoter polymorphism -174G/C in Saudi women with hypertensive disorders of pregnancy
Nervana M. Bayoumy, Ashwag S. Al-Sharaidh, Zainab H. Babay, Abdulgalil M. Abdulgader
Saudi Medical Journal Jul 2013, 34 (7) 689-694;

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The role of interleukin-6 promoter polymorphism -174G/C in Saudi women with hypertensive disorders of pregnancy
Nervana M. Bayoumy, Ashwag S. Al-Sharaidh, Zainab H. Babay, Abdulgalil M. Abdulgader
Saudi Medical Journal Jul 2013, 34 (7) 689-694;
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© 2025 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

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