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Research ArticleOriginal Article
Open Access

Comparison of herbal-based and synthetic hemostatic agents for efficacy on a rat partial nephrectomy model. Experimental study

Murat Bagcioglu, Emre Huri, Mumtaz Dadali, Hesna M. Astarci, Mustafa F. Sargon and Muzaffer Eroglu
Saudi Medical Journal January 2014, 35 (1) 33-38;
Murat Bagcioglu
Department of Urology, Ankara Training and Research Hospital, Ankara, Turkey
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Emre Huri
Department of Urology, Ankara Training and Research Hospital, Ankara, Turkey
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Mumtaz Dadali
Department of Urology, Ankara Training and Research Hospital, Ankara, Turkey
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Hesna M. Astarci
Department of Urology, Ankara Training and Research Hospital, Ankara, Turkey
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Mustafa F. Sargon
Department of Urology, Ankara Training and Research Hospital, Ankara, Turkey
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Muzaffer Eroglu
Department of Urology, Ankara Training and Research Hospital, Ankara, Turkey
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Abstract

OBJECTIVE: To compare the efficacy of herbal based and synthetic hemostatic agents in partial nephrectomy.

METHODS: Our experimental study was carried out at the Ankara Training and Research Hospital, Ankara, Turkey between May and November 2012. Twenty rats were randomly divided into 4 groups. Intracorporeal sutures (group K), TachoSil (group T), HaemoCer (group H), and Ankaferd Blood Stopper (group A) were used to achieve hemostasis in partial nephrectomy. Warm ischemia time (WIT), hemostasis time (HT), and blood loss for all groups were measured. The specimens were examined histopathologically and electron microscopically after sacrificing the rats.

RESULTS: The fastest hemostasis was detected in group T, followed by group H, and group A. The WIT and HT were significantly different for all groups (p<0.001). The greatest blood loss was found in group K. The histopathologic examination revealed that the giant cell reaction in group K was significantly more than in group H and group A (p<0.001). No pathologic findings were observed in the ultrastructural examination of specimens taken from group K. On ultrastructural examination of group T, tubule cells had many vacuoles in their cytoplasm with marked intracellular edema. Ultrastructural findings for groups H and A were similar.

CONCLUSION: At the histopathologic and ultrastructural levels, herbal-based hemostatic agents had a positive impact on renal tissue and glomerular function when applied during partial nephrectomy.

  • Copyright: © Saudi Medical Journal

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Saudi Medical Journal: 35 (1)
Saudi Medical Journal
Vol. 35, Issue 1
1 Jan 2014
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Comparison of herbal-based and synthetic hemostatic agents for efficacy on a rat partial nephrectomy model. Experimental study
Murat Bagcioglu, Emre Huri, Mumtaz Dadali, Hesna M. Astarci, Mustafa F. Sargon, Muzaffer Eroglu
Saudi Medical Journal Jan 2014, 35 (1) 33-38;

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Comparison of herbal-based and synthetic hemostatic agents for efficacy on a rat partial nephrectomy model. Experimental study
Murat Bagcioglu, Emre Huri, Mumtaz Dadali, Hesna M. Astarci, Mustafa F. Sargon, Muzaffer Eroglu
Saudi Medical Journal Jan 2014, 35 (1) 33-38;
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© 2025 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

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