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Research ArticleOriginal Article
Open Access

Effect of infliximab against cisplatin-induced nephrotoxicity

Erkan Cure, Aynur Kirbas, Levent Tumkaya, Medine C. Cure, Osman Z. Şahin, Yildiray Kalkan, Suleyman Yuce and Durdu Altuner
Saudi Medical Journal September 2014, 35 (9) 953-958;
Erkan Cure
Department of Internal Medicine, School of Medicine, Recep Tayyip Erdogan University, Rize 53100, Turkey. Tel. +90 (464) 2130491 Ext. 1859. Fax. +90 (464) 2170364. E-mail. [email protected]
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Aynur Kirbas
Department of Internal Medicine, School of Medicine, Recep Tayyip Erdogan University, Rize 53100, Turkey. Tel. +90 (464) 2130491 Ext. 1859. Fax. +90 (464) 2170364. E-mail. [email protected]
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Levent Tumkaya
Department of Internal Medicine, School of Medicine, Recep Tayyip Erdogan University, Rize 53100, Turkey. Tel. +90 (464) 2130491 Ext. 1859. Fax. +90 (464) 2170364. E-mail. [email protected]
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Medine C. Cure
Department of Internal Medicine, School of Medicine, Recep Tayyip Erdogan University, Rize 53100, Turkey. Tel. +90 (464) 2130491 Ext. 1859. Fax. +90 (464) 2170364. E-mail. [email protected]
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Osman Z. Şahin
Department of Internal Medicine, School of Medicine, Recep Tayyip Erdogan University, Rize 53100, Turkey. Tel. +90 (464) 2130491 Ext. 1859. Fax. +90 (464) 2170364. E-mail. [email protected]
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Yildiray Kalkan
Department of Internal Medicine, School of Medicine, Recep Tayyip Erdogan University, Rize 53100, Turkey. Tel. +90 (464) 2130491 Ext. 1859. Fax. +90 (464) 2170364. E-mail. [email protected]
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Suleyman Yuce
Department of Internal Medicine, School of Medicine, Recep Tayyip Erdogan University, Rize 53100, Turkey. Tel. +90 (464) 2130491 Ext. 1859. Fax. +90 (464) 2170364. E-mail. [email protected]
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Durdu Altuner
Department of Internal Medicine, School of Medicine, Recep Tayyip Erdogan University, Rize 53100, Turkey. Tel. +90 (464) 2130491 Ext. 1859. Fax. +90 (464) 2170364. E-mail. [email protected]
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Abstract

OBJECTIVES: To investigate whether infliximab (Ib), an inhibitor of tumor necrosis factor alpha (TNF-±), prevents cisplatin (Cis)-induced nephrotoxicity.

METHODS: The study was performed in the Department of Internal Medicine, Recep Tayyip Erdogan University, Rize, Turkey, between November 2012 and May 2013. Thirty male Wistar albino rats were divided into 3 groups, a control group, a Cis group, and a Cis+Ib group. The animals of the Cis group were injected with a single dose (7 mg/kg) of Cis intraperitoneally. The animals of the Cis+Ib group were injected with a single dose (7 mg/kg) of Ib 72 hours prior to Cis injection.

RESULTS: The TNF-±, interleukin-1 beta (IL-1b), nitric oxide (NO) and adenosine deaminase (ADA) levels of the Cis group were higher than both the control group TNF-± (p<0.001), IL-1± (p<0.001), NO (p<0.001) and ADA (p<0.001), and the Cis+Ib group TNF-± (p<0.001), IL-1b (p<0.001), NO (p<0.001), and ADA (p=0.003). Histopathological examination revealed extensive damage in the Cis group, while the damage in the Cis+Ib group was lower. While the carbonic anhydrase II (CA-II) level of the Cis group was lower than both groups, it was similar in the Cis+Ib and the control groups.

CONCLUSION: Infliximab acts against Cis-induced nephrotoxicity by a strong inhibition of TNF-±. Additionally, the combination of these 2 drugs does not obviously change the level of CA-II.

  • Copyright: © Saudi Medical Journal

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Saudi Medical Journal: 35 (9)
Saudi Medical Journal
Vol. 35, Issue 9
1 Sep 2014
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Effect of infliximab against cisplatin-induced nephrotoxicity
Erkan Cure, Aynur Kirbas, Levent Tumkaya, Medine C. Cure, Osman Z. Şahin, Yildiray Kalkan, Suleyman Yuce, Durdu Altuner
Saudi Medical Journal Sep 2014, 35 (9) 953-958;

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Effect of infliximab against cisplatin-induced nephrotoxicity
Erkan Cure, Aynur Kirbas, Levent Tumkaya, Medine C. Cure, Osman Z. Şahin, Yildiray Kalkan, Suleyman Yuce, Durdu Altuner
Saudi Medical Journal Sep 2014, 35 (9) 953-958;
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© 2025 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

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