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Research ArticleOriginal Article
Open Access

Protective effect of seed oil of Herpetospermum pedunculosum against carbon tetrachloride-induced liver injury in rats

Gang Li, Xiao-Yan Wang, You-Rui Suo and Hong-Lun Wang
Saudi Medical Journal September 2014, 35 (9) 981-987;
Gang Li
School of Life Science, Yantai University, Yantai, and the Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining, China. E-mail. [email protected]
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Xiao-Yan Wang
School of Life Science, Yantai University, Yantai, and the Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining, China. E-mail. [email protected]
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You-Rui Suo
School of Life Science, Yantai University, Yantai, and the Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining, China. E-mail. [email protected]
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Hong-Lun Wang
School of Life Science, Yantai University, Yantai, and the Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining, China. E-mail. [email protected]
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Abstract

OBJECTIVES: To investigate the protective effect of Herpetospermum pedunculosum (H. pedunculosum) seed oil against carbon tetrachloride (CCl4)-induced liver damage.

METHODS: This experimental study was conducted at the Northwest Institute of Plateau Biology, Chinese Academy of Sciences, and Yantai University, China from November 2012 to May 2013. The H. pedunculosum seed oil was extracted using supercritical carbon dioxide. The antioxidant activities of H. pedunculosum seed oil were assayed in vitro by 2,2-diphenyl-1-picrylhydrazyl assay, lipid peroxidation assay, and antihemolytic assay. Adult Sprague Dawley rats were randomly divided into 6 groups (10 rats/group) including control, CCl4, CCl4+bifendate, and CCl4+H. pedunculosum seed oil (3 different doses) groups.

RESULTS: The CCl4-induced liver lesions include hepatocyte necrosis, ballooning degeneration, calcification, and fibrosis. Moreover, CCl4 damage results in an obvious increase of serum triglycerides, high-density lipoprotein, low-density lipoprotein, malondialdehyde, total bilirubin, alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase activity. In addition, CCl4 also significantly decreased the activities of superoxide dismutase (SOD). By contrast, H. pedunculosum seed oil administration significantly ameliorated the CCl4-induced liver lesions, lowered the serum levels of hepatic enzyme markers, and increased the activities of SOD.

CONCLUSION: The results of this study show that H. pedunculosum seed oil can be proposed to protect the liver against CCl4-induced oxidative damage in rats, and the hepatoprotective effect might be correlated with its potent antioxidant and free radical scavenging effect.

  • Copyright: © Saudi Medical Journal

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Saudi Medical Journal: 35 (9)
Saudi Medical Journal
Vol. 35, Issue 9
1 Sep 2014
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Protective effect of seed oil of Herpetospermum pedunculosum against carbon tetrachloride-induced liver injury in rats
Gang Li, Xiao-Yan Wang, You-Rui Suo, Hong-Lun Wang
Saudi Medical Journal Sep 2014, 35 (9) 981-987;

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Protective effect of seed oil of Herpetospermum pedunculosum against carbon tetrachloride-induced liver injury in rats
Gang Li, Xiao-Yan Wang, You-Rui Suo, Hong-Lun Wang
Saudi Medical Journal Sep 2014, 35 (9) 981-987;
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© 2025 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

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