Skip to main content

Main menu

  • Home
  • Content
    • Latest
    • Archive
    • home
  • Info for
    • Authors
    • Reviewers
    • Subscribers
    • Institutions
    • Advertisers
    • Join SMJ
  • About Us
    • About Us
    • Editorial Office
    • Editorial Board
  • More
    • Advertising
    • Alerts
    • Feedback
    • Folders
    • Help
  • Other Publications
    • NeuroSciences Journal

User menu

  • My alerts
  • Log in

Search

  • Advanced search
Saudi Medical Journal
  • Other Publications
    • NeuroSciences Journal
  • My alerts
  • Log in
Saudi Medical Journal

Advanced Search

  • Home
  • Content
    • Latest
    • Archive
    • home
  • Info for
    • Authors
    • Reviewers
    • Subscribers
    • Institutions
    • Advertisers
    • Join SMJ
  • About Us
    • About Us
    • Editorial Office
    • Editorial Board
  • More
    • Advertising
    • Alerts
    • Feedback
    • Folders
    • Help
  • Follow psmmc on Twitter
  • Visit psmmc on Facebook
  • RSS
Research ArticleOriginal Article
Open Access

Clinical utility of dabigatran in United Arab Emirates

A pharmacovigilance study

Abdulla Shehab, Asim A. Elnour, Adel Sadik, Mahmoud Abu Mandil, Ali AlShamsi, Aesha Al Suwaidi, AkshayaSrikanth Bhagavathula, Pinar Erkekoglu, Farah Hamad and Saif K. Al Nuaimi
Saudi Medical Journal November 2015, 36 (11) 1290-1298; DOI: https://doi.org/10.15537/smj.2015.11.12154
Abdulla Shehab
From the Departments of Internal Medicine (Shehab), Pharmacology (Elnour), College of Medicine and Health Sciences, United Arab Emirates University, the Pharmaceutical Institute (Elnour, Sadik, Abu Mandil), Internal Medicine Department (Al Suwaidi), Al-Ain Hospital, the Internal Medicine Department (AlShamsi, Al Nuaimi), Tawam Hospital, Abu Dhabi Health Services (SEHA), Al-Ain, and the Department of Pharmaceutics (Hamad), Ajman University of Sciences and Technology, Ajman, United Arab Emirates, and the Department of Clinical Pharmacy (Bhagavathula), College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia, and the Department of Toxicology (Erkekoglu), Faculty of Pharmacy, Hacettepe University, Sihhiye, Ankara, Turkey
FRCP, PhD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: [email protected]
Asim A. Elnour
From the Departments of Internal Medicine (Shehab), Pharmacology (Elnour), College of Medicine and Health Sciences, United Arab Emirates University, the Pharmaceutical Institute (Elnour, Sadik, Abu Mandil), Internal Medicine Department (Al Suwaidi), Al-Ain Hospital, the Internal Medicine Department (AlShamsi, Al Nuaimi), Tawam Hospital, Abu Dhabi Health Services (SEHA), Al-Ain, and the Department of Pharmaceutics (Hamad), Ajman University of Sciences and Technology, Ajman, United Arab Emirates, and the Department of Clinical Pharmacy (Bhagavathula), College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia, and the Department of Toxicology (Erkekoglu), Faculty of Pharmacy, Hacettepe University, Sihhiye, Ankara, Turkey
MSc, PhD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Adel Sadik
From the Departments of Internal Medicine (Shehab), Pharmacology (Elnour), College of Medicine and Health Sciences, United Arab Emirates University, the Pharmaceutical Institute (Elnour, Sadik, Abu Mandil), Internal Medicine Department (Al Suwaidi), Al-Ain Hospital, the Internal Medicine Department (AlShamsi, Al Nuaimi), Tawam Hospital, Abu Dhabi Health Services (SEHA), Al-Ain, and the Department of Pharmaceutics (Hamad), Ajman University of Sciences and Technology, Ajman, United Arab Emirates, and the Department of Clinical Pharmacy (Bhagavathula), College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia, and the Department of Toxicology (Erkekoglu), Faculty of Pharmacy, Hacettepe University, Sihhiye, Ankara, Turkey
MSc, PhD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mahmoud Abu Mandil
From the Departments of Internal Medicine (Shehab), Pharmacology (Elnour), College of Medicine and Health Sciences, United Arab Emirates University, the Pharmaceutical Institute (Elnour, Sadik, Abu Mandil), Internal Medicine Department (Al Suwaidi), Al-Ain Hospital, the Internal Medicine Department (AlShamsi, Al Nuaimi), Tawam Hospital, Abu Dhabi Health Services (SEHA), Al-Ain, and the Department of Pharmaceutics (Hamad), Ajman University of Sciences and Technology, Ajman, United Arab Emirates, and the Department of Clinical Pharmacy (Bhagavathula), College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia, and the Department of Toxicology (Erkekoglu), Faculty of Pharmacy, Hacettepe University, Sihhiye, Ankara, Turkey
MSc
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ali AlShamsi
From the Departments of Internal Medicine (Shehab), Pharmacology (Elnour), College of Medicine and Health Sciences, United Arab Emirates University, the Pharmaceutical Institute (Elnour, Sadik, Abu Mandil), Internal Medicine Department (Al Suwaidi), Al-Ain Hospital, the Internal Medicine Department (AlShamsi, Al Nuaimi), Tawam Hospital, Abu Dhabi Health Services (SEHA), Al-Ain, and the Department of Pharmaceutics (Hamad), Ajman University of Sciences and Technology, Ajman, United Arab Emirates, and the Department of Clinical Pharmacy (Bhagavathula), College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia, and the Department of Toxicology (Erkekoglu), Faculty of Pharmacy, Hacettepe University, Sihhiye, Ankara, Turkey
MD, FRCP
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Aesha Al Suwaidi
From the Departments of Internal Medicine (Shehab), Pharmacology (Elnour), College of Medicine and Health Sciences, United Arab Emirates University, the Pharmaceutical Institute (Elnour, Sadik, Abu Mandil), Internal Medicine Department (Al Suwaidi), Al-Ain Hospital, the Internal Medicine Department (AlShamsi, Al Nuaimi), Tawam Hospital, Abu Dhabi Health Services (SEHA), Al-Ain, and the Department of Pharmaceutics (Hamad), Ajman University of Sciences and Technology, Ajman, United Arab Emirates, and the Department of Clinical Pharmacy (Bhagavathula), College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia, and the Department of Toxicology (Erkekoglu), Faculty of Pharmacy, Hacettepe University, Sihhiye, Ankara, Turkey
MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
AkshayaSrikanth Bhagavathula
From the Departments of Internal Medicine (Shehab), Pharmacology (Elnour), College of Medicine and Health Sciences, United Arab Emirates University, the Pharmaceutical Institute (Elnour, Sadik, Abu Mandil), Internal Medicine Department (Al Suwaidi), Al-Ain Hospital, the Internal Medicine Department (AlShamsi, Al Nuaimi), Tawam Hospital, Abu Dhabi Health Services (SEHA), Al-Ain, and the Department of Pharmaceutics (Hamad), Ajman University of Sciences and Technology, Ajman, United Arab Emirates, and the Department of Clinical Pharmacy (Bhagavathula), College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia, and the Department of Toxicology (Erkekoglu), Faculty of Pharmacy, Hacettepe University, Sihhiye, Ankara, Turkey
Pharm D
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Pinar Erkekoglu
From the Departments of Internal Medicine (Shehab), Pharmacology (Elnour), College of Medicine and Health Sciences, United Arab Emirates University, the Pharmaceutical Institute (Elnour, Sadik, Abu Mandil), Internal Medicine Department (Al Suwaidi), Al-Ain Hospital, the Internal Medicine Department (AlShamsi, Al Nuaimi), Tawam Hospital, Abu Dhabi Health Services (SEHA), Al-Ain, and the Department of Pharmaceutics (Hamad), Ajman University of Sciences and Technology, Ajman, United Arab Emirates, and the Department of Clinical Pharmacy (Bhagavathula), College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia, and the Department of Toxicology (Erkekoglu), Faculty of Pharmacy, Hacettepe University, Sihhiye, Ankara, Turkey
MSc, PhD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Farah Hamad
From the Departments of Internal Medicine (Shehab), Pharmacology (Elnour), College of Medicine and Health Sciences, United Arab Emirates University, the Pharmaceutical Institute (Elnour, Sadik, Abu Mandil), Internal Medicine Department (Al Suwaidi), Al-Ain Hospital, the Internal Medicine Department (AlShamsi, Al Nuaimi), Tawam Hospital, Abu Dhabi Health Services (SEHA), Al-Ain, and the Department of Pharmaceutics (Hamad), Ajman University of Sciences and Technology, Ajman, United Arab Emirates, and the Department of Clinical Pharmacy (Bhagavathula), College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia, and the Department of Toxicology (Erkekoglu), Faculty of Pharmacy, Hacettepe University, Sihhiye, Ankara, Turkey
MSc, PhD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Saif K. Al Nuaimi
From the Departments of Internal Medicine (Shehab), Pharmacology (Elnour), College of Medicine and Health Sciences, United Arab Emirates University, the Pharmaceutical Institute (Elnour, Sadik, Abu Mandil), Internal Medicine Department (Al Suwaidi), Al-Ain Hospital, the Internal Medicine Department (AlShamsi, Al Nuaimi), Tawam Hospital, Abu Dhabi Health Services (SEHA), Al-Ain, and the Department of Pharmaceutics (Hamad), Ajman University of Sciences and Technology, Ajman, United Arab Emirates, and the Department of Clinical Pharmacy (Bhagavathula), College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia, and the Department of Toxicology (Erkekoglu), Faculty of Pharmacy, Hacettepe University, Sihhiye, Ankara, Turkey
MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • eLetters
  • Info & Metrics
  • References
  • PDF
Loading

References

  1. ↵
    1. Centers for Disease Control and Prevention (CDC)
    Atrial Fibrillation. CDC, Available from:http://www.cdc.gov/dhdsp/data_statistics/fact_sheets/docs/fs_atrial_fibrillation.pdf. Accessed 2014 December.
  2. ↵
    1. Lip GY,
    2. Brechin CM,
    3. Lane DA
    (2012) The global burden of atrial fibrillation and stroke: a systematic review of the epidemiology of atrial fibrillation in regions outside North America and Europe. Chest 142:1489–1498.
    OpenUrlCrossRefPubMedWeb of Science
  3. ↵
    1. Pan X,
    2. Simon TA,
    3. Hamilton M,
    4. Kuznik A
    (2015) Comparison of costs and discharge outcomes for patients hospitalized for ischemic or hemorrhagic stroke with or without atrial fibrillation in the United States. J Thromb Thrombolysis 39:508–515.
    OpenUrlCrossRefPubMed
  4. ↵
    1. McBride D,
    2. Mattenklotz AM,
    3. Willich SN,
    4. Brüggenjürgen B
    (2009) The costs of care in atrial fibrillation and the effect of treatment modalities in Germany. Value Health 12:293–301.
    OpenUrlCrossRefPubMedWeb of Science
  5. ↵
    1. European Heart Rhythm Association; European Association for Cardio-Thoracic Surgery,
    2. Camm AJ,
    3. Kirchhof P,
    4. Lip GY,
    5. Schotten U,
    6. et al.
    (2010) Guidelines for the management of atrial fibrillation: the Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology (ESC). Eur Heart J 31:2369–2429.
    OpenUrlCrossRefPubMedWeb of Science
  6. ↵
    1. Yap YG,
    2. Camm J
    (2014) Epidemiology of Atrial fibrillation. In Essentials of Atrial fibrillation (Springer Healthcare, London (UK)), pp 1–5.
  7. ↵
    1. Wolowacz SE,
    2. Samuel M,
    3. Brennan VK,
    4. Jasso-Mosqueda JG,
    5. Van Gelder IC
    (2011) The cost of illness of atrial fibrillation: a systematic review of the recent literature. Europace 13:1375–1385.
    OpenUrlCrossRefPubMedWeb of Science
  8. ↵
    1. Gladstone DJ,
    2. Bui E,
    3. Fang J,
    4. Laupacis A,
    5. Lindsay MP,
    6. Tu JV,
    7. et al.
    (2009) Potentially preventable strokes in high-risk patients with atrial fibrillation who are not adequately anticoagulated. Stroke 40:235–240.
    OpenUrlAbstract/FREE Full Text
  9. ↵
    1. Banerjee A,
    2. Fauchier L,
    3. Vourc’h P,
    4. Andres CR,
    5. Taillandier S,
    6. Halimi JM,
    7. et al.
    (2013) Renal impairment and ischemic stroke risk assessment in patients with atrial fibrillation: the Loire Valley Atrial Fibrillation Project. J Am Coll Cardiol 61:2079–2087.
    OpenUrlFREE Full Text
  10. ↵
    1. Coppens M,
    2. Eikelboom JW,
    3. Hart RG,
    4. Yusuf S,
    5. Lip GY,
    6. Dorian P,
    7. et al.
    (2013) The CHA2DS2-VASc score identifies those patients with atrial fibrillation and a CHADS2 score of 1 who are unlikely to benefit from oral anticoagulant therapy. Eur Heart J 34:170–176.
    OpenUrlCrossRefPubMedWeb of Science
  11. ↵
    1. Pisters R,
    2. Lane DA,
    3. Nieuwlaat R,
    4. de Vos CB,
    5. Crijns HJ,
    6. Lip GY
    (2010) A novel user-friendly score (HAS-BLED) to assess 1-year risk of major bleeding in patients with atrial fibrillation: the Euro Heart Survey. Chest 138:1093–1100.
    OpenUrlCrossRefPubMedWeb of Science
  12. ↵
    1. Ahrens I,
    2. Lip GY,
    3. Peter K
    (2010) New oral anticoagulant drugs in cardiovascular disease. Thromb Haemost 104:49–60.
    OpenUrlPubMedWeb of Science
  13. ↵
    1. Contractor T,
    2. Levin V,
    3. Martinez MW,
    4. Marchlinski FE
    (2013) Novel oral anticoagulants for stroke prevention in patients with atrial fibrillation: dawn of a new era. Postgrad Med 125:34–44.
    OpenUrlCrossRef
  14. ↵
    1. U.S. Food and Drug Administration
    FDA approves Pradaxa to prevent stroke in people with atrial fibrillation, Available from:http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm230241.htm. Updated 2013 April 19, Accessed 2014 November.
  15. ↵
    1. Marshall S,
    2. Fearon P,
    3. Dawson J,
    4. Quinn TJ
    (2013) Stop the clots, but at what cost? Pharmacoeconomics of dabigatran etexilate for the prevention of stroke in subjects with atrial fibrillation: a systematic literature review. Expert Rev Pharmacoecon Outcomes Res 13:29–42.
    OpenUrl
  16. ↵
    1. Connolly SJ,
    2. Ezekowitz MD,
    3. Yusuf S,
    4. Eikelboom J,
    5. Oldgren J,
    6. Parekh A,
    7. et al.
    (2009) Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med 361:1139–1151.
    OpenUrlCrossRefPubMedWeb of Science
    1. Wallentin L,
    2. Yusuf S,
    3. Ezekowitz MD,
    4. Alings M,
    5. Flather M,
    6. Franzosi MG,
    7. et al.
    (2010) Efficacy and safety of dabigatran compared with warfarin at different levels of international normalised ratio control for stroke prevention in atrial fibrillation: an analysis of the RE-LY trial. Lancet 376:975–983.
    OpenUrlCrossRefPubMedWeb of Science
  17. ↵
    1. Eikelboom JW,
    2. Wallentin L,
    3. Connolly SJ,
    4. Ezekowitz M,
    5. Healey JS,
    6. Oldgren J,
    7. et al.
    (2011) Risk of bleeding with 2 doses of dabigatran compared with warfarin in older and younger patients with atrial fibrillation: an analysis of the randomized evaluation of long-term anticoagulant therapy (RE-LY) trial. Circulation 123:2363–2372.
    OpenUrlAbstract/FREE Full Text
  18. ↵
    1. Southworth MR,
    2. Reichman ME,
    3. Unger EF
    (2013) Dabigatran and postmarketing reports of bleeding. N Engl J Med 368:1272–1274.
    OpenUrlCrossRefPubMedWeb of Science
  19. ↵
    1. Hernandez I,
    2. Baik SH,
    3. Piñera A,
    4. Zhang Y
    (2015) Risk of bleeding with dabigatran in atrial fibrillation. JAMA Intern Med 175:18–24.
    OpenUrl
  20. ↵
    1. Joppi R,
    2. Cinconze E,
    3. Mezzalira L,
    4. Pase D,
    5. Poggiani C,
    6. Rossi E,
    7. et al.
    (2013) Hospitalized patients with atrial fibrillation compared to those included in recent trials on novel oral anticoagulants: a population-based study. Eur J Intern Med 24:318–323.
    OpenUrlCrossRefPubMed
  21. ↵
    1. Camm AJ,
    2. Lip GY,
    3. De Caterina R,
    4. Savelieva I,
    5. Atar D,
    6. Hohnloser SH,
    7. et al.
    (2012) 2012 focused update of the ESC Guidelines for the management of atrial fibrillation: an update of the 2010 ESC Guidelines for the management of atrial fibrillation. Developed with the special contribution of the European Heart Rhythm Association. Eur Heart J 33:2719–2747.
    OpenUrlCrossRefPubMedWeb of Science
    1. You JJ,
    2. Singer DE,
    3. Howard PA,
    4. Lane DA,
    5. Eckman MH,
    6. Fang MC,
    7. et al.
    (2012) Antithrombotic therapy for atrial fibrillation: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 141(2 Suppl):e531S–e575S.
    OpenUrlCrossRefPubMedWeb of Science
  22. ↵
    1. Skanes AC,
    2. Healey JS,
    3. Cairns JA,
    4. Dorian P,
    5. Gillis AM,
    6. McMurtry MS,
    7. et al.
    (2012) Focused 2012 update of the Canadian Cardiovascular Society atrial fibrillation guidelines: recommendations for stroke prevention and rate/rhythm control. Can J Cardiol 28:125–136.
    OpenUrlCrossRefPubMed
  23. ↵
    1. Lakkireddy D,
    2. Reddy YM,
    3. Di Biase L,
    4. Vanga SR,
    5. Santangeli P,
    6. Swarup V,
    7. et al.
    (2012) Feasibility and safety of dabigatran versus warfarin for periprocedural anticoagulation in patients undergoing radiofrequency ablation for atrial fibrillation: results from a multicenter prospective registry. J Am Coll Cardiol 59:1168–1174.
    OpenUrlFREE Full Text
  24. ↵
    1. Connolly SJ,
    2. Reilly PA,
    3. Pogue J,
    4. Eikelboom J,
    5. Oldgren J,
    6. Ezekowitz MD,
    7. et al.
    (2012) Randomized comparison of the effects of two doses of dabigatran etexilate on clinical outcomes over 4.3 years: results of the RELY-ABLE double-blind randomized trial. Circulation 126:2793.
    OpenUrl
  25. ↵
    1. Connolly SJ,
    2. Ezekowitz MD,
    3. Yusuf S,
    4. Reilly PA,
    5. Wallentin L
    (2010) Randomized Evaluation of Long-Term Anticoagulation Therapy Investigators. Newly identified events in the RE-LY trial. N Engl J Med 363:1875–1876.
    OpenUrlCrossRefPubMedWeb of Science
  26. ↵
    1. Lip GY,
    2. Larsen TB,
    3. Skjøth F,
    4. Rasmussen LH
    (2012) Indirect comparisons of new oral anticoagulant drugs for efficacy and safety when used for stroke prevention in atrial fibrillation. J Am Coll Cardiol 60:738–746.
    OpenUrlFREE Full Text
  27. ↵
    1. Uchino K,
    2. Hernandez AV
    (2012) Dabigatran association with higher risk of acute coronary events: meta-analysis of noninferiority randomized controlled trials. Arch Intern Med 172:397–402.
    OpenUrlCrossRefPubMedWeb of Science
  28. ↵
    1. Larsen TB,
    2. Rasmussen LH,
    3. Skjøth F,
    4. Due KM,
    5. Callréus T,
    6. Rosenzweig M,
    7. et al.
    (2013) Efficacy and safety of dabigatran etexilate and warfarin in “real-world” patients with atrial fibrillation: a prospective nationwide cohort study. J Am Coll Cardiol 61:2264–2273.
    OpenUrlFREE Full Text
  29. ↵
    1. Huisman MV,
    2. Lip GY,
    3. Diener HC,
    4. Dubner SJ,
    5. Halperin JL,
    6. Ma CS,
    7. et al.
    (2014) Design and rationale of Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation: a global registry program on long-term oral antithrombotic treatment in patients with atrial fibrillation. Am Heart J 167:329–334.
    OpenUrlCrossRefPubMedWeb of Science
  30. ↵
    1. Dogliotti A,
    2. Paolasso E,
    3. Giugliano RP
    (2013) Novel oral anticoagulants in atrial fibrillation: a meta-analysis of large, randomized, controlled trials vs warfarin. Clin Cardiol 36:61–67.
    OpenUrlCrossRefPubMed
  31. ↵
    1. Granger CB,
    2. Alexander JH,
    3. McMurray JJ,
    4. Lopes RD,
    5. Hylek EM,
    6. Hanna M,
    7. et al.
    (2011) Apixaban versus warfarin in patients with atrial fibrillation. N Engl J Med 365:981–992.
    OpenUrlCrossRefPubMedWeb of Science
    1. Giugliano RP,
    2. Ruff CT,
    3. Braunwald E,
    4. Murphy SA,
    5. Wiviott SD,
    6. Halperin JL,
    7. et al.
    (2013) Edoxaban versus warfarin in patients with atrial fibrillation. N Engl J Med 369:2093–2104.
    OpenUrlCrossRefPubMedWeb of Science
  32. ↵
    1. Patel MR,
    2. Mahaffey KW,
    3. Garg J,
    4. Pan G,
    5. Singer DE,
    6. Hacke W,
    7. et al.
    (2011) Rivaroxaban versus warfarin in nonvalvular atrial fibrillation. N Engl J Med 365:883–891.
    OpenUrlCrossRefPubMedWeb of Science
  33. ↵
    1. Larock AS,
    2. Mullier F,
    3. Sennesael AL,
    4. Douxfils J,
    5. Devalet B,
    6. Chatelain C,
    7. et al.
    (2014) Appropriateness of prescribing dabigatran etexilate and rivaroxaban in patients with nonvalvular atrial fibrillation: a prospective study. Ann Pharmacother 48:1258–1268.
    OpenUrlCrossRefPubMed
  34. ↵
    1. Troncoso A,
    2. Diogène E
    (2014) Dabigatran and rivaroxaban prescription for atrial fibrillation in Catalonia, Spain: the need to manage the introduction of new drugs. Euro J Clin Pharmacol 70:249–250.
    OpenUrl
  35. ↵
    1. Malmström RE,
    2. Godman BB,
    3. Diogene E,
    4. Baumgärtel C,
    5. Bennie M,
    6. Bishop I,
    7. et al.
    (2013) Dabigatran - a case history demonstrating the need for comprehensive approaches to optimize the use of new drugs. Front Pharmacol 4:39.
    OpenUrl
  36. ↵
    1. Harper P,
    2. Young L,
    3. Merriman E
    (2012) Bleeding Risk with Dabigatran in the Frail Elderly. N Eng J Med 366:864–866.
    OpenUrlCrossRefPubMed
  37. ↵
    1. Reilly PA,
    2. Lehr T,
    3. Haertter S,
    4. Connolly SJ,
    5. Yusuf S,
    6. Eikelboom JW,
    7. et al.
    (2014) The effect of dabigatran plasma concentrations and patient characteristics on the frequency of ischemic stroke and major bleeding in atrial fibrillation patients: the RE-LY Trial (Randomized Evaluation of Long-Term Anticoagulation Therapy). J Am Coll Cardiol 63:321–328.
    OpenUrlFREE Full Text
  38. ↵
    1. Cohen D
    (2014) Dabigatran: how the drug company withheld important analyses. BMJ 349:g4670.
    OpenUrlFREE Full Text
  39. ↵
    1. Moore TJ,
    2. Cohen MR,
    3. Mattison DR
    (2014) Dabigatran, bleeding, and the regulators. BMJ 349:g4517.
    OpenUrlFREE Full Text
  40. ↵
    1. Huisman MV,
    2. Lip GY,
    3. Diener HC,
    4. Brueckmann M,
    5. van Ryn J,
    6. Clemens A
    (2012) Dabigatran etexilate for stroke prevention in patients with atrial fibrillation: resolving uncertainties in routine practice. Thromb Haemost 107:838–847.
    OpenUrlCrossRefPubMed
  41. ↵
    1. Godman B,
    2. Malmström RE,
    3. Diogene E,
    4. Jayathissa S,
    5. McTaggart S,
    6. Cars T,
    7. et al.
    (2014) Dabigatran - a continuing exemplar case history demonstrating the need for comprehensive models to optimize the utilization of new drugs. Front Pharmacol 5:109.
    OpenUrl
PreviousNext
Back to top

In this issue

Saudi Medical Journal: 36 (11)
Saudi Medical Journal
Vol. 36, Issue 11
1 Nov 2015
  • Table of Contents
  • Cover (PDF)
  • Index by author
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on Saudi Medical Journal.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Clinical utility of dabigatran in United Arab Emirates
(Your Name) has sent you a message from Saudi Medical Journal
(Your Name) thought you would like to see the Saudi Medical Journal web site.
Citation Tools
Clinical utility of dabigatran in United Arab Emirates
Abdulla Shehab, Asim A. Elnour, Adel Sadik, Mahmoud Abu Mandil, Ali AlShamsi, Aesha Al Suwaidi, AkshayaSrikanth Bhagavathula, Pinar Erkekoglu, Farah Hamad, Saif K. Al Nuaimi
Saudi Medical Journal Nov 2015, 36 (11) 1290-1298; DOI: 10.15537/smj.2015.11.12154

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Clinical utility of dabigatran in United Arab Emirates
Abdulla Shehab, Asim A. Elnour, Adel Sadik, Mahmoud Abu Mandil, Ali AlShamsi, Aesha Al Suwaidi, AkshayaSrikanth Bhagavathula, Pinar Erkekoglu, Farah Hamad, Saif K. Al Nuaimi
Saudi Medical Journal Nov 2015, 36 (11) 1290-1298; DOI: 10.15537/smj.2015.11.12154
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Bookmark this article

Jump to section

  • Article
    • Abstract
    • Methods
    • Results
    • Discussion
    • Acknowledgment
    • Footnotes
    • References
  • Figures & Data
  • eLetters
  • References
  • Info & Metrics
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • No citing articles found.
  • Google Scholar

More in this TOC Section

  • The factors affecting comfort and the comfort levels of patients hospitalized in the coronary intensive care unit
  • Exploring communication challenges with children and parents among pharmacists in Saudi Arabia
  • Exploring hypothyroidism’s effects on lipid profiles
Show more Original Article

Similar Articles

CONTENT

  • home

JOURNAL

  • home

AUTHORS

  • home
Saudi Medical Journal

© 2025 Saudi Medical Journal Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.

Powered by HighWire