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Research ArticleOriginal Article
Open Access

Genetic polymorphisms in paraoxonase 1 and G protein-coupled receptor 77, and the risk of glucose-6-phosphate dehydrogenase deficiency in a Saudi population

Khalid K. Alharbi
Saudi Medical Journal May 2015, 36 (5) 544-548; DOI: https://doi.org/10.15537/smj.2015.5.11860
Khalid K. Alharbi
From the Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Kingdom of Saudi Arabia
MSc, PhD
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References

  1. ↵
    1. Renzaho AM,
    2. Husser E,
    3. Polonsky M
    (2014) Should blood donors be routinely screened for glucose-6-phosphate dehydrogenase deficiency?A systematic review of clinical studies focusing on patients transfused with glucose-6-phosphate dehydrogenase-deficient red cells. Transfus Med Rev 28:7–17.
    OpenUrl
  2. ↵
    1. Olusanya BO,
    2. Emokpae AA,
    3. Zamora TG,
    4. Slusher TM
    (2014) Addressing the burden of neonatal hyperbilirubinaemia in countries with significant glucose-6-phosphate dehydrogenase deficiency. Acta Paediatr, Epub ahead of print.
    1. Relling MV,
    2. McDonagh EM,
    3. Chang T,
    4. Caudle KE,
    5. McLeod HL,
    6. Haidar CE,
    7. et al.
    (2014) Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for rasburicase therapy in the context of G6PD deficiency genotype. Clin Pharmacol Ther 96:169–174.
    OpenUrlCrossRefPubMed
  3. ↵
    1. Alharbi KK,
    2. Khan IA
    (2014) Prevalence of glucose-6-phosphate dehydrogenase deficiency and the role of the A- variant in a Saudi population. J Int Med Res 42:1161–1167.
    OpenUrlCrossRefPubMed
  4. ↵
    1. Francis RO,
    2. Jhang JS,
    3. Pham HP,
    4. Hod EA,
    5. Zimring JC,
    6. Spitalnik SL
    (2013) Glucose-6-phosphate dehydrogenase deficiency in transfusion medicine: the unknown risks. Vox Sang 105:271–282.
    OpenUrl
  5. ↵
    1. Alharbi KK,
    2. Khan IA,
    3. Abed AS,
    4. Syed R
    (2013) Insertion/Deletion polymorphisms do play any role in G6PD deficiency individuals in the Kingdom of the Saudi Arabia. Bioinformation 9:49–53.
    OpenUrlCrossRefPubMed
  6. ↵
    1. Gari MA,
    2. Chaudhary AG,
    3. Al-Qahtani MH,
    4. Abuzenadah AM,
    5. Waseem A,
    6. Banni H,
    7. et al.
    (2010) Frequency of Mediterranean mutation among a group of Saudi G6PD patients in Western region-Jeddah. Int J Lab Hematol 32:17–21.
    OpenUrlCrossRefPubMed
  7. ↵
    1. Al-Jaouni SK,
    2. Jarullah J,
    3. Azhar E,
    4. Moradkhani K
    (2011) Molecular characterization of glucose-6-phosphate dehydrogenase deficiency in Jeddah, Kingdom of Saudi Arabia. BMC Res Notes 4:436.
    OpenUrlCrossRefPubMed
  8. ↵
    1. Alharbi KK,
    2. Khan IA,
    3. Syed R
    (2012) Thrombophilic gene polymorphism studies in G6PD deficient individuals from Saudi population. Bioinformation 8:1255–1259.
    OpenUrl
  9. ↵
    1. Hassan MA,
    2. Al-Attas OS,
    3. Hussain T,
    4. Al-Daghri NM,
    5. Alokail MS,
    6. Mohammed AK,
    7. et al.
    (2013) The Q192R polymorphism of the paraoxonase 1 gene is a risk factor for coronary artery disease in Saudi subjects. Mol Cell Biochem 380:121–128.
    OpenUrlCrossRefPubMed
  10. ↵
    1. Al-Hakeem MM,
    2. Abotalib Z,
    3. Alharbi KK,
    4. Khan IA
    (2014) Relationship between the paraoxonase 1 gene glutamine 192 to arginine polymorphism and gestational diabetes mellitus in Saudi women. Clin Biochem 47:122–125.
    OpenUrl
  11. ↵
    1. Alharbi KK,
    2. Khan IA,
    3. Syed R
    (2013) Circulating C5L2 gene polymorphism is associated with type 2 diabetes mellitus in Saudi population. Mol Biol Rep 40:6323–6327.
    OpenUrl
  12. ↵
    1. Phompradit P,
    2. Kuesap J,
    3. Chaijaroenkul W,
    4. Rueangweerayut R,
    5. Hongkaew Y,
    6. Yamnuan R,
    7. et al.
    (2011) Prevalence and distribution of glucose-6-phosphate dehydrogenase (G6PD) variants in Thai and Burmese populations in malaria endemic areas of Thailand. Malar J 10:368.
    OpenUrlCrossRefPubMed
  13. ↵
    1. Gomez-Manzo S,
    2. Terron-Hernandez J,
    3. de la Mora-de la Mora I,
    4. Garcia-Torres I,
    5. Lopez-Velazquez G,
    6. Reyes-Vivas H,
    7. et al.
    (2013) Cloning, expression, purification and characterization of his-tagged human glucose-6-phosphate dehydrogenase: a simplified method for protein yield. Protein J 32:585–592.
    OpenUrl
  14. ↵
    1. Pinna A,
    2. Contini EL,
    3. Carru C,
    4. Solinas G
    (2013) Glucose-6-phosphate dehydrogenase deficiency and diabetes mellitus with severe retinal complications in a Sardinian population, Italy. Int J Med Sci 10:1907–1913.
    OpenUrl
    1. Heymann AD,
    2. Cohen Y,
    3. Chodick G
    (2012) Glucose-6-phosphate dehydrogenase deficiency and type 2 diabetes. Diabetes Care 35:e58.
    OpenUrlFREE Full Text
  15. ↵
    1. Cappai G,
    2. Songini M,
    3. Doria A,
    4. Cavallerano JD,
    5. Lorenzi M
    (2011) Increased prevalence of proliferative retinopathy in patients with type 1 diabetes who are deficient in glucose-6-phosphate dehydrogenase. Diabetologia 54:1539–1542.
    OpenUrlCrossRefPubMedWeb of Science
  16. ↵
    1. von Seidlein L,
    2. Auburn S,
    3. Espino F,
    4. Shanks D,
    5. Cheng Q,
    6. McCarthy J,
    7. et al.
    (2013) Review of key knowledge gaps in glucose-6-phosphate dehydrogenase deficiency detection with regard to the safe clinical deployment of 8-aminoquinoline treatment regimens: a workshop report. Malar J 12:112.
    OpenUrlCrossRefPubMed
  17. ↵
    1. Hussein YM,
    2. Gharib AF,
    3. Etewa RL,
    4. ElSawy WH
    (2011) Association of L55M and Q192R polymorphisms in paraoxonase 1 (PON1) gene with breast cancer risk and their clinical significance. Mol Cell Biochem 351:117–123.
    OpenUrlCrossRefPubMed
  18. ↵
    1. Ergun MA,
    2. Yurtcu E,
    3. Demirci H,
    4. Ilhan MN,
    5. Barkar V,
    6. Yetkin I,
    7. et al.
    (2011) PON1 55 and 192 gene polymorphisms in type 2 diabetes mellitus patients in a Turkish population. Biochem Genet 49:1–8.
    OpenUrlCrossRefPubMed
  19. ↵
    1. Ruperez AI,
    2. Lopez-Guarnido O,
    3. Gil F,
    4. Olza J,
    5. Gil-Campos M,
    6. Leis R,
    7. et al.
    (2013) Paraoxonase 1 activities and genetic variation in childhood obesity. Br J Nutr 110:1639–1647.
    OpenUrl
    1. Bhaskar S,
    2. Ganesan M,
    3. Chandak GR,
    4. Mani R,
    5. Idris MM,
    6. Khaja N,
    7. et al.
    (2011) Association of PON1 and APOA5 gene polymorphisms in a cohort of Indian patients having coronary artery disease with and without type 2 diabetes. Genet Test Mol Biomarkers 15:507–512.
    OpenUrlPubMed
    1. Zhang G,
    2. Li W,
    3. Li Z,
    4. Lv H,
    5. Ren Y,
    6. Ma R,
    7. et al.
    (2013) Association between paraoxonase gene and stroke in the Han Chinese population. BMC Med Genet 14:16.
    OpenUrl
    1. Pi Y,
    2. Zhang L,
    3. Chang K,
    4. Li B,
    5. Guo L,
    6. Fang C,
    7. et al.
    (2012) Lack of an association between Paraoxonase 1 gene polymorphisms (Q192R, L55M) and Alzheimer’s disease: a meta-analysis. Neurosci Lett 523:174–179.
    OpenUrlPubMed
  20. ↵
    1. Saadat M
    (2012) Paraoxonase 1 genetic polymorphisms and susceptibility to breast cancer: a meta-analysis. Cancer Epidemiol 36:e101–e103.
    OpenUrlPubMed
  21. ↵
    1. Sibireva OF
    (2011) Association of hemostatic disorders in diabetic patients with methylenetetrahydrofolate reductase (C677T) and coagulation factors II (G20210A) and V (G1691A) gene polymorphism. Klin Lab Diagn 3:36–39.
    OpenUrl
    1. Rahimi Z,
    2. Felehgari V,
    3. Rahimi M,
    4. Mozafari H,
    5. Yari K,
    6. Vaisi-Raygani A,
    7. et al.
    (2011) The frequency of factor V Leiden mutation, ACE gene polymorphism, serum ACE activity and response to ACE inhibitor and angiotensin II receptor antagonist drugs in Iranians type II diabetic patients with microalbuminuria. Mol Biol Rep 38:2117–2123.
    OpenUrlCrossRefPubMed
  22. ↵
    1. Rahimi Z,
    2. Hasanvand A,
    3. Felehgari V
    (2012) Interaction of MTHFR 1298C with ACE D allele augments the risk of diabetic nephropathy in Western Iran. DNA Cell Biol 31:553–559.
    OpenUrlCrossRefPubMedWeb of Science
  23. ↵
    1. Flora SJ,
    2. Mittal M,
    3. Pachauri V,
    4. Dwivedi N
    (2012) A possible mechanism for combined arsenic and fluoride induced cellular and DNA damage in mice. Metallomics 4:78–90.
    OpenUrlPubMed
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Saudi Medical Journal: 36 (5)
Saudi Medical Journal
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1 May 2015
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Genetic polymorphisms in paraoxonase 1 and G protein-coupled receptor 77, and the risk of glucose-6-phosphate dehydrogenase deficiency in a Saudi population
Khalid K. Alharbi
Saudi Medical Journal May 2015, 36 (5) 544-548; DOI: 10.15537/smj.2015.5.11860

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Genetic polymorphisms in paraoxonase 1 and G protein-coupled receptor 77, and the risk of glucose-6-phosphate dehydrogenase deficiency in a Saudi population
Khalid K. Alharbi
Saudi Medical Journal May 2015, 36 (5) 544-548; DOI: 10.15537/smj.2015.5.11860
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