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Research ArticleOriginal Article
Open Access

Visual and neurologic sequelae of methanol poisoning in Saudi Arabia

Alberto Galvez-Ruiz, Sahar M. Elkhamary, Nasira Asghar and Thomas M. Bosley
Saudi Medical Journal May 2015, 36 (5) 568-574; DOI: https://doi.org/10.15537/smj.2015.5.11142
Alberto Galvez-Ruiz
From the Departments of Ophthalmology (Galvez-Ruiz), Diagnostic Imaging (Elkhamary), and Research (Ashgar), King Khaled Eye Specialist Hospital, and the Department of Ophthalmology (Bosley), College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia
MD
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  • For correspondence: [email protected]
Sahar M. Elkhamary
From the Departments of Ophthalmology (Galvez-Ruiz), Diagnostic Imaging (Elkhamary), and Research (Ashgar), King Khaled Eye Specialist Hospital, and the Department of Ophthalmology (Bosley), College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia
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Nasira Asghar
From the Departments of Ophthalmology (Galvez-Ruiz), Diagnostic Imaging (Elkhamary), and Research (Ashgar), King Khaled Eye Specialist Hospital, and the Department of Ophthalmology (Bosley), College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia
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Thomas M. Bosley
From the Departments of Ophthalmology (Galvez-Ruiz), Diagnostic Imaging (Elkhamary), and Research (Ashgar), King Khaled Eye Specialist Hospital, and the Department of Ophthalmology (Bosley), College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia
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References

  1. ↵
    1. Barceloux DG,
    2. Bond GR,
    3. Krenzelok EP,
    4. Cooper H,
    5. Vale JA
    (2002) American Academy of Clinical Toxicology Ad Hoc Committee on the Treatment Guidelines for Methanol Poisoning. American Academy of Clinical Toxicology Practice Guidelines on the Treatment of Methanol Poisoning. J Toxicol Clin Toxicol 40:415–446.
    OpenUrlCrossRefPubMedWeb of Science
  2. ↵
    1. Kraut JA,
    2. Kurtz I
    (2008) Toxic alcohol ingestions: clinical features, diagnosis, and management. Clin J Am Soc Nephrol 3:208–225.
    OpenUrlAbstract/FREE Full Text
  3. ↵
    1. Ingemansson SO
    (1984) Clinical observations on ten cases of methanol poisoning with particular reference to ocular manifestations. Acta Ophthalmol (Copenh) 62:15–24.
    OpenUrlPubMed
  4. ↵
    1. Bennett IL Jr.,
    2. Cary FH,
    3. Mitchell GL Jr.,
    4. Cooper MN
    (1953) Acute methyl alcohol poisoning: a review based on experiences in an outbreak of 323 cases. Medicine (Baltimore) 32:431–463.
    OpenUrlCrossRefPubMedWeb of Science
  5. ↵
    1. Hovda KE,
    2. Hunderi OH,
    3. Tafjord AB,
    4. Dunlop O,
    5. Rudberg N,
    6. Jacobsen D
    (2005) Methanol outbreak in Norway 2002-2004: epidemiology, clinical features and prognostic signs. J Intern Med 258:181–190.
    OpenUrlCrossRefPubMedWeb of Science
  6. ↵
    1. Paasma R,
    2. Hovda KE,
    3. Jacobsen D
    (2009) Methanol poisoning and long term sequelae - a six years follow-up after a large methanol outbreak. BMC Clin Pharmacol 9:5.
    OpenUrlCrossRefPubMed
  7. ↵
    1. Paasma R,
    2. Hovda KE,
    3. Tikkerberi A,
    4. Jacobsen D
    (2007) Methanol mass poisoning in Estonia: outbreak in 154 patients. Clin Toxicol (Phila) 45:152–157.
    OpenUrlPubMed
  8. ↵
    1. Sanaei-Zadeh H,
    2. Zamani N,
    3. Shadnia S
    (2011) Outcomes of visual disturbances after methanol poisoning. Clin Toxicol (Phila) 49:102–107.
    OpenUrlCrossRefPubMed
  9. ↵
    1. Benton CD Jr.,
    2. Calhoun FP Jr.
    (1952) The ocular effects of methyl alcohol poisoning: report of a catastrophe involving three hundred and twenty persons. Trans Am Acad Ophthalmol Otolaryngol 56:875–885.
    OpenUrlPubMed
  10. ↵
    1. Jain N,
    2. Himanshu D,
    3. Verma SP,
    4. Parihar A
    (2013) Methanol poisoning: characteristic MRI findings. Ann Saudi Med 33:68–69.
    OpenUrlPubMed
  11. ↵
    1. Hovda KE,
    2. Froyshov S,
    3. Gudmundsdottir H,
    4. Rudberg N,
    5. Jacobsen D
    (2005) Fomepizole may change indication for hemodialysis in methanol poisoning: prospective study in seven cases. Clin Nephrol 64:190–197.
    OpenUrlCrossRefPubMedWeb of Science
  12. ↵
    1. Prabhakaran V,
    2. Ettler H,
    3. Mills A
    (1993) Methanol poisoning: two cases with similar plasma methanol concentrations but different outcomes. CMAJ 148:981–984.
    OpenUrlPubMed
  13. ↵
    1. Sharpe JA,
    2. Hostovsky M,
    3. Bilbao JM,
    4. Rewcastle NB
    (1982) Methanol optic neuropathy: a histopathological study. Neurology 32:1093–1100.
    OpenUrlCrossRefPubMed
  14. ↵
    1. Karayel F,
    2. Turan AA,
    3. Sav A,
    4. Pakis I,
    5. Akyildiz EU,
    6. Ersoy G
    (2010) Methanol intoxication: pathological changes of central nervous system (17 cases). Am J Forensic Med Pathol 31:34–36.
    OpenUrlCrossRefPubMed
  15. ↵
    1. Reddy NJ,
    2. Sudini M,
    3. Lewis LD
    (2010) Delayed neurological sequelae from ethylene glycol, diethylene glycol and methanol poisonings. Clin Toxicol (Phila) 48:967–973.
    OpenUrlPubMed
  16. ↵
    1. Lee SL,
    2. Shih HT,
    3. Chi YC,
    4. Li YP,
    5. Yin SJ
    (2011) Oxidation of methanol, ethylene glycol, and isopropanol with human alcohol dehydrogenases and the inhibition by ethanol and 4-methylpyrazole. Chem Biol Interact 191:26–31.
    OpenUrlCrossRefPubMed
  17. ↵
    1. Martin-Amat G,
    2. Tephly TR,
    3. McMartin KE,
    4. Makar AB,
    5. Hayreh MS,
    6. Hayreh SS,
    7. et al.
    (1977) Methyl alcohol poisoning. II. Development of a model for ocular toxicity in methyl alcohol poisoning using the rhesus monkey. Arch Ophthalmol 95:1847–1850.
    OpenUrlCrossRefPubMedWeb of Science
    1. Hayreh MS,
    2. Hayreh SS,
    3. Baumbach GL,
    4. Cancilla P,
    5. Martin-Amat G,
    6. Tephly TR,
    7. et al.
    (1977) Methyl alcohol poisoning III. Ocular toxicity. Arch Ophthalmol 95:1851–1858.
    OpenUrlCrossRefPubMedWeb of Science
  18. ↵
    1. Baumbach GL,
    2. Cancilla PA,
    3. Martin-Amat G,
    4. Tephly TR,
    5. McMartin KE,
    6. Makar AB,
    7. et al.
    (1977) Methyl alcohol poisoning. IV. Alterations of the morphological findings of the retina and optic nerve. Arch Ophthalmol 95:1859–1865.
    OpenUrlCrossRefPubMedWeb of Science
  19. ↵
    1. Sadun A
    (1998) Acquired mitochondrial impairment as a cause of optic nerve disease. Trans Am Ophthalmol Soc 96:881–923.
    OpenUrlPubMed
  20. ↵
    1. Barron MJ,
    2. Griffiths P,
    3. Turnbull DM,
    4. Bates D,
    5. Nichols P
    (2004) The distributions of mitochondria and sodium channels reflect the specific energy requirements and conduction properties of the human optic nerve head. Br J Ophthalmol 88:286–290.
    OpenUrlAbstract/FREE Full Text
  21. ↵
    1. McKellar MJ,
    2. Hidajat RR,
    3. Elder MJ
    (1997) Acute ocular methanol toxicity: clinical and electrophysiological features. Aust N Z J Ophthalmol 25:225–230.
    OpenUrlCrossRefPubMedWeb of Science
  22. ↵
    1. Eells JT,
    2. Henry MM,
    3. Summerfelt P,
    4. Wong-Riley MT,
    5. Buchmann EV,
    6. Kane M,
    7. et al.
    (2003) Therapeutic photobiomodulation for methanol-induced retinal toxicity. Proc Natl Acad Sci U S A 100:3439–3444.
    OpenUrlAbstract/FREE Full Text
  23. ↵
    1. Sanaei-Zadeh H
    (2012) Typical bilateral putaminal lesions of methanol intoxication. J Emerg Med 42:178–179.
    OpenUrlPubMed
  24. ↵
    1. Taheri MS,
    2. Moghaddam HH,
    3. Moharamzad Y,
    4. Dadgari S,
    5. Nahvi V
    (2010) The value of brain CT findings in acute methanol toxicity. Eur J Radiol 73:211–214.
    OpenUrlCrossRefPubMed
  25. ↵
    1. Leng Y,
    2. Liu Y,
    3. Fang X,
    4. Li Y,
    5. Yu L,
    6. Yuan Y,
    7. et al.
    (2015) The mitochondrial DNA 10197 G>A mutation causes MELAS/Leigh overlap syndrome presenting with acute auditory agnosia. Mitochondrial DNA 26:208–212.
    OpenUrlCrossRefPubMed
  26. ↵
    1. Abu-Amero KK,
    2. Bosley TM,
    3. Bohlega S,
    4. McLean D
    (2005) Complex I respiratory defect in LHON plus dystonia with no mitochondrial DNA mutation. Br J Ophthalmol 89:1380–1381.
    OpenUrlFREE Full Text
  27. ↵
    1. Hovda KE,
    2. Andersson KS,
    3. Urdal P,
    4. Jacobsen D
    (2005) Methanol and formate kinetics during treatment with fomepizole. Clin Toxicol (Phila) 43:221–227.
    OpenUrlPubMed
  28. ↵
    1. Sanaei-Zadeh H,
    2. Zamani N,
    3. Shahmohammadi F
    (2011) Can fomepizole be substituted by abacavir in the treatment of methanol poisoning? J Med Toxicol 7:179–180.
    OpenUrlPubMed
  29. ↵
    1. Sanaei-Zadeh H
    (2012) Is high-dose intravenous steroid effective on preserving vision in acute methanol poisoning? Optom Vis Sci 89:244.
    OpenUrlPubMed
  30. ↵
    1. Stelmach MZ,
    2. O’Day J
    (1992) Partly reversible visual failure with methanol toxicity. Aust N Z J Ophthalmol 20:57–64.
    OpenUrlCrossRefPubMedWeb of Science
  31. ↵
    1. Al Aseri Z,
    2. Altamimi S
    (2009) Keeping a high index of suspicion: lessons learned in the management of methanol ingestion. BMJ Case Rep 2009:pii:bcr09.2008.1013.
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Saudi Medical Journal: 36 (5)
Saudi Medical Journal
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1 May 2015
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Visual and neurologic sequelae of methanol poisoning in Saudi Arabia
Alberto Galvez-Ruiz, Sahar M. Elkhamary, Nasira Asghar, Thomas M. Bosley
Saudi Medical Journal May 2015, 36 (5) 568-574; DOI: 10.15537/smj.2015.5.11142

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Visual and neurologic sequelae of methanol poisoning in Saudi Arabia
Alberto Galvez-Ruiz, Sahar M. Elkhamary, Nasira Asghar, Thomas M. Bosley
Saudi Medical Journal May 2015, 36 (5) 568-574; DOI: 10.15537/smj.2015.5.11142
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