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Review ArticleSystematic Reviews
Open Access

Do statins really cause diabetes?

A meta-analysis of major randomized controlled clinical trials

Alaa J. Rahal, Ahmed I. ElMallah, Rita J. Poushuju and Rana Itani
Saudi Medical Journal October 2016, 37 (10) 1051-1060; DOI: https://doi.org/10.15537/smj.2016.10.16078
Alaa J. Rahal
From the Department of Pharmacology and Therapeutics (Rahal, Poushijian, Itani), Faculty of Pharmacy, Beirut Arab University, Beirut, Lebanon, and the Department of Pharmacology & Therapeutics (ElMallah), Faculty of Pharmacy, Pharos University in Alexandria, Alexandria, Egypt
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  • For correspondence: [email protected]
Ahmed I. ElMallah
From the Department of Pharmacology and Therapeutics (Rahal, Poushijian, Itani), Faculty of Pharmacy, Beirut Arab University, Beirut, Lebanon, and the Department of Pharmacology & Therapeutics (ElMallah), Faculty of Pharmacy, Pharos University in Alexandria, Alexandria, Egypt
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Rita J. Poushuju
From the Department of Pharmacology and Therapeutics (Rahal, Poushijian, Itani), Faculty of Pharmacy, Beirut Arab University, Beirut, Lebanon, and the Department of Pharmacology & Therapeutics (ElMallah), Faculty of Pharmacy, Pharos University in Alexandria, Alexandria, Egypt
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Rana Itani
From the Department of Pharmacology and Therapeutics (Rahal, Poushijian, Itani), Faculty of Pharmacy, Beirut Arab University, Beirut, Lebanon, and the Department of Pharmacology & Therapeutics (ElMallah), Faculty of Pharmacy, Pharos University in Alexandria, Alexandria, Egypt
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    Figure 1

    Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines flow diagram of literature search for identification of studies.

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    Figure 2

    Association between statin therapy and incident diabetes in 14 major randomized controlled trials. 4S - Scandinavian Simvastatin Survival Study Group, AFCAPS/TexCAPS - Air Force/Texas Coronary Atherosclerosis Prevention Study, GISSI Prev - Gruppo Italiano per lo Studio della Sopravvivenza nell’Infarto Miocardico Prevention, WOSCOPS - West of Scotland Coronary Prevention Study, PROSPER - Pravastatin in elderly individuals at risk of vascular disease, ALLHAT - Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial, ASCOT-LLA - Anglo-Scandinavian Cardiac Outcomes Trial-Lipid Lowering Arm, LIPID - Long-Term Intervention with Pravastatin in Ischaemic Disease Group, HPS - Heart Protection Study, MEGA - Management of Elevated Cholesterol in the Primary Prevention Group of Adult Japanese, CORONA - Controlled Rosuvastatin Multinational Trial in Heart Failure Trial, JUPITER - Justification for the Use of Statins in Primary Prevention: An Intervention Trial Evaluating Rosuvastatin trial, HR - heart failure, SPARCL - Stroke Prevention by Aggressive Reduction in Cholesterol Levels, 95% CI - 95% confidence interval

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    Figure 3

    Cumulative meta-analysis of the studied clinical trial by year of publication. 4S - Scandinavian Simvastatin Survival Study Group, AFCAPS/TexCAPS - Air Force/Texas Coronary Atherosclerosis Prevention Study, GISSI Prev - Gruppo Italiano per lo Studio della Sopravvivenza nell’Infarto Miocardico Prevention, WOSCOPS - West of Scotland Coronary Prevention Study, PROSPER - Pravastatin in elderly individuals at risk of vascular disease, ALLHAT - Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial, ASCOT-LLA - Anglo-Scandinavian Cardiac Outcomes Trial-Lipid Lowering Arm, LIPID - Long-Term Intervention with Pravastatin in Ischaemic Disease Group, HPS - Heart Protection Study, MEGA - Management of Elevated Cholesterol in the Primary Prevention Group of Adult Japanese, CORONA - Controlled Rosuvastatin Multinational Trial in Heart Failure Trial, JUPITER - Justification for the Use of Statins in Primary Prevention: An Intervention Trial Evaluating Rosuvastatin trial, HR - heart failure, SPARCL - Stroke Prevention by Aggressive Reduction in Cholesterol Levels, 95% CI - 95% confidence interval

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    Figure 4

    Funnel plot of standard error by log odds ratio for the included studies on statin induced diabetes.

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    Figure 5

    Association between individual statins and incidental diabetes mellitus. 95% CI - 95% confidence interval

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Saudi Medical Journal: 37 (10)
Saudi Medical Journal
Vol. 37, Issue 10
1 Oct 2016
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Do statins really cause diabetes?
Alaa J. Rahal, Ahmed I. ElMallah, Rita J. Poushuju, Rana Itani
Saudi Medical Journal Oct 2016, 37 (10) 1051-1060; DOI: 10.15537/smj.2016.10.16078

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Do statins really cause diabetes?
Alaa J. Rahal, Ahmed I. ElMallah, Rita J. Poushuju, Rana Itani
Saudi Medical Journal Oct 2016, 37 (10) 1051-1060; DOI: 10.15537/smj.2016.10.16078
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