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Research ArticleOriginal Article
Open Access

Molecular epidemiology of pneumococcal isolates from children in China

Li-Hua Kang, Meng-Juan Liu, Wen-Chun Xu, Jing-Jing Cui, Xue-Mei Zhang, Kai-Feng Wu and Qun Zhang
Saudi Medical Journal April 2016, 37 (4) 403-413; DOI: https://doi.org/10.15537/smj.2016.4.14507
Li-Hua Kang
From the Key Laboratory of Diagnostic Medicine designated by the Ministry of Education (Kang, Liu, Xu, Cui, Zhang X, Wu), College of Laboratory Medicine, Chongqing Medical University, the Medicine Laboratory (Zhang Q), Children’s Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, the Department of Laboratory Medicine (Wu), the Third Affiliated Hospital of Zunyi Medical College, Zunyi, China
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Meng-Juan Liu
From the Key Laboratory of Diagnostic Medicine designated by the Ministry of Education (Kang, Liu, Xu, Cui, Zhang X, Wu), College of Laboratory Medicine, Chongqing Medical University, the Medicine Laboratory (Zhang Q), Children’s Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, the Department of Laboratory Medicine (Wu), the Third Affiliated Hospital of Zunyi Medical College, Zunyi, China
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Wen-Chun Xu
From the Key Laboratory of Diagnostic Medicine designated by the Ministry of Education (Kang, Liu, Xu, Cui, Zhang X, Wu), College of Laboratory Medicine, Chongqing Medical University, the Medicine Laboratory (Zhang Q), Children’s Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, the Department of Laboratory Medicine (Wu), the Third Affiliated Hospital of Zunyi Medical College, Zunyi, China
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Jing-Jing Cui
From the Key Laboratory of Diagnostic Medicine designated by the Ministry of Education (Kang, Liu, Xu, Cui, Zhang X, Wu), College of Laboratory Medicine, Chongqing Medical University, the Medicine Laboratory (Zhang Q), Children’s Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, the Department of Laboratory Medicine (Wu), the Third Affiliated Hospital of Zunyi Medical College, Zunyi, China
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Xue-Mei Zhang
From the Key Laboratory of Diagnostic Medicine designated by the Ministry of Education (Kang, Liu, Xu, Cui, Zhang X, Wu), College of Laboratory Medicine, Chongqing Medical University, the Medicine Laboratory (Zhang Q), Children’s Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, the Department of Laboratory Medicine (Wu), the Third Affiliated Hospital of Zunyi Medical College, Zunyi, China
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Kai-Feng Wu
From the Key Laboratory of Diagnostic Medicine designated by the Ministry of Education (Kang, Liu, Xu, Cui, Zhang X, Wu), College of Laboratory Medicine, Chongqing Medical University, the Medicine Laboratory (Zhang Q), Children’s Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, the Department of Laboratory Medicine (Wu), the Third Affiliated Hospital of Zunyi Medical College, Zunyi, China
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Qun Zhang
From the Key Laboratory of Diagnostic Medicine designated by the Ministry of Education (Kang, Liu, Xu, Cui, Zhang X, Wu), College of Laboratory Medicine, Chongqing Medical University, the Medicine Laboratory (Zhang Q), Children’s Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, the Department of Laboratory Medicine (Wu), the Third Affiliated Hospital of Zunyi Medical College, Zunyi, China
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References

  1. ↵
    1. O’Brien KL,
    2. Wolfson LJ,
    3. Watt JP,
    4. Henkle E,
    5. Deloria-Knoll M,
    6. McCall N,
    7. et al.
    (2009) Burden of disease caused by Streptococcus pneumoniae in children younger than 5 years: global estimates. Lancet 374:893–902.
    OpenUrlCrossRefPubMedWeb of Science
  2. ↵
    1. Wierzbowski AK,
    2. Karlowsky JA,
    3. Adam HJ,
    4. Nichol KA,
    5. Hoban DJ,
    6. Zhanel GG
    (2014) Canadian Antimicrobial Resistance Alliance. Evolution and molecular characterization of macrolide-resistant Streptococcus pneumoniae in Canada between 1998 and 2008. J Antimicrob Chemother 69:59–66.
    OpenUrlCrossRefPubMedWeb of Science
  3. ↵
    1. Kim SH,
    2. Song JH,
    3. Chung DR,
    4. Thamlikitkul V,
    5. Yang Y,
    6. Wang H,
    7. et al.
    (2012) Changing trends in antimicrobial resistance and serotypes of Streptococcus pneumoniae isolates in Asian countries: an Asian Network for Surveillance of Resistant Pathogens (ANSORP) study. Antimicrob Agents Chemother 56:1418–1426.
    OpenUrlAbstract/FREE Full Text
  4. ↵
    1. Geng Q,
    2. Zhang T,
    3. Ding Y,
    4. Tao Y,
    5. Lin Y,
    6. Wang Y,
    7. et al.
    (2014) Molecular characterization and antimicrobial susceptibility of Streptococcus pneumoniae isolated from children hospitalized with respiratory infections in Suzhou, China. PLoS One 9:e93752.
    OpenUrlCrossRefPubMed
  5. ↵
    1. Hanquet G,
    2. Kissling E,
    3. Fenoll A,
    4. George R,
    5. Lepoutre A,
    6. Lernout T,
    7. et al.
    (2010) Pneumococcal serotypes in children in 4 European countries. Emerg Infect Dis 16:1428–1439.
    OpenUrlCrossRefPubMed
  6. ↵
    1. Esposito S,
    2. Principi N
    (2015) Impacts of the 13-valent pneumococcal conjugate vaccine in children. J Immunol Res 2015:591580.
    OpenUrl
  7. ↵
    1. Zhou L,
    2. Yu SJ,
    3. Gao W,
    4. Yao KH,
    5. Shen AD,
    6. Yang YH
    (2011) Serotype distribution and antibiotic resistance of 140 pneumococcal isolates from pediatric patients with upper respiratory infections in Beijing 2010. Vaccine 29:7704–7710.
    OpenUrl
  8. ↵
    1. Xue L,
    2. Yao K,
    3. Xie G,
    4. Zheng Y,
    5. Wang C,
    6. Shang Y,
    7. et al.
    (2010) Serotype distribution and antimicrobial resistance of Streptococcus pneumoniae isolates that cause invasive disease among Chinese children. Clin Infect Dis 50:741–744.
    OpenUrlCrossRefPubMed
  9. ↵
    1. Zhao C,
    2. Zhang F,
    3. Chu Y,
    4. Liu Y,
    5. Cao B,
    6. Chen M,
    7. et al.
    (2013) Phenotypic and genotypic characteristic of invasive pneumococcal isolates from both children and adult patients from a multicenter surveillance in China 2005-2011. PLoS One 8:e82361.
    OpenUrlCrossRefPubMed
  10. ↵
    1. Hill PC,
    2. Townend J,
    3. Antonio M,
    4. Akisanya B,
    5. Ebruke C,
    6. Lahai G,
    7. et al.
    (2010) Transmission of Streptococcus pneumoniae in rural Gambian villages: a longitudinal study. Clin Infect Dis 50:1468–1476.
    OpenUrlCrossRefPubMed
  11. ↵
    1. Browall S,
    2. Norman M,
    3. Tangrot J,
    4. Galanis I,
    5. Sjostrom K,
    6. Dagerhamn J,
    7. et al.
    (2014) Intraclonal variations among Streptococcus pneumoniae isolates influence the likelihood of invasive disease in children. J Infect Dis 209:377–388.
    OpenUrlCrossRefPubMed
  12. ↵
    1. Sakai F,
    2. Talekar SJ,
    3. Klugman KP,
    4. Vidal JE
    (2013) Expression of virulence-related genes in the nasopharynx of healthy children. PLoS One 8:e67147.
    OpenUrlCrossRefPubMed
  13. ↵
    1. Abdullahi O,
    2. Karani A,
    3. Tigoi CC,
    4. Mugo D,
    5. Kungu S,
    6. Wanjiru E,
    7. et al.
    (2012) Rates of acquisition and clearance of pneumococcal serotypes in the nasopharynges of children in Kilifi District, Kenya. J Infect Dis 206:1020–1029.
    OpenUrlCrossRefPubMed
  14. ↵
    1. Bogaert D,
    2. De Groot R,
    3. Hermans P
    (2004) Streptococcus pneumoniae colonisation: the key to pneumococcal disease. Lancet Infect Dis 4:144–154.
    OpenUrlCrossRefPubMedWeb of Science
  15. ↵
    1. Resti M,
    2. Moriondo M,
    3. Cortimiglia M,
    4. Indolfi G,
    5. Canessa C,
    6. Becciolini L,
    7. et al.
    (2010) Community-acquired bacteremic pneumococcal pneumonia in children: diagnosis and serotyping by real-time polymerase chain reaction using blood samples. Clin Infect Dis 51:1042–1049.
    OpenUrlCrossRefPubMedWeb of Science
  16. ↵
    1. Siira L,
    2. Kaijalainen T,
    3. Lambertsen L,
    4. Nahm MH,
    5. Toropainen M,
    6. Virolainen A
    (2012) From Quellung to multiplex PCR, and back when needed, in pneumococcal serotyping. J Clin Microbiol 50:2727–2731.
    OpenUrlAbstract/FREE Full Text
  17. ↵
    1. Donkor ES,
    2. Stabler RA,
    3. Hinds J,
    4. Adegbola RA,
    5. Antonio M,
    6. Wren BW
    (2012) Comparative phylogenomics of Streptococcus pneumoniae isolated from invasive disease and nasopharyngeal carriage from West Africans. BMC Genomics 13:569.
    OpenUrlPubMed
  18. ↵
    1. Wayne P
    (2012) Methods for Dilution Antimicrobial Susceptibility Tests f or Bacteria That Grow Aerobically; Approved Standard - Ninth Edition. CLSI Document M07-A9. Wayne (Pennsylvania): Clinical and Laboratory Standards Institute. Available from:antimicrobianos.com.ar/ATB/wp-content/.../03-CLSI-M07-A9-2012.pdf.
  19. ↵
    1. Wayne P
    (2014) Performance Standards for Antimicrobial Susceptibility Testing; Twenty-Fourth Informational Supplement. CLSI Document M100-S24. Wayne (Pennsylvania): Clinical and Laboratory Standards Institute, Available from:http://ncipd.org/control/images/NCIPD_docs/CLSI_M100-S24.pdf.
  20. ↵
    1. Melin M,
    2. Trzciński K,
    3. Antonio M,
    4. Meri S,
    5. Adegbola R,
    6. Kaijalainen T,
    7. et al.
    (2010) Serotype-related variation in susceptibility to complement deposition and opsonophagocytosis among clinical isolates of Streptococcus pneumoniae. Infect Immun 78:5252–5261.
    OpenUrlAbstract/FREE Full Text
  21. ↵
    1. Aguinagalde L,
    2. Corsini B,
    3. Domenech A,
    4. Domenech M,
    5. Camara J,
    6. Ardanuy C,
    7. et al.
    (2015) Emergence of amoxicillin-resistant variants of Spain9V-ST156 pneumococci expressing serotype 11A correlates with their ability to evade the host immune response. PLoS One 10:e0137565.
    OpenUrlCrossRef
  22. ↵
    1. Jaiswal N,
    2. Singh M,
    3. Das RR,
    4. Jindal I,
    5. Agarwal A,
    6. Thumburu KK,
    7. et al.
    (2014) Distribution of serotypes, vaccine coverage, and antimicrobial susceptibility pattern of Streptococcus pneumoniae in children living in SAARC countries: a systematic review. PLoS One 9:e108617.
    OpenUrlCrossRefPubMed
    1. Bewick T,
    2. Sheppard C,
    3. Greenwood S,
    4. Slack M,
    5. Trotter C,
    6. George R,
    7. et al.
    (2012) Serotype prevalence in adults hospitalised with pneumococcal non-invasive community-acquired pneumonia. Thorax 67:540–545.
    OpenUrlAbstract/FREE Full Text
  23. ↵
    1. Saha SK,
    2. Naheed A,
    3. El Arifeen S,
    4. Islam M,
    5. Al-Emran H,
    6. Amin R,
    7. et al.
    (2009) Surveillance for invasive Streptococcus pneumoniae disease among hospitalized children in Bangladesh: antimicrobial susceptibility and serotype distribution. Clin Infect Dis 48(Suppl 2):S75–S81.
    OpenUrlCrossRefPubMed
  24. ↵
    1. Balaji V,
    2. Jayaraman R,
    3. Verghese VP,
    4. Baliga PR,
    5. Kurien T
    (2015) Pneumococcal serotypes associated with invasive disease in under five children in India and implications for vaccine policy. Indian J Med Res 142:286–292.
    OpenUrlCrossRefPubMed
  25. ↵
    1. Jauneikaite E,
    2. Mary Carnon Jefferies J,
    3. William Vere Churton N,
    4. Tzer Pin Lin R,
    5. Lloyd Hibberd M,
    6. Charles Clarke S
    (2014) Genetic diversity of Streptococcus pneumoniae causing meningitis and sepsis in Singapore during the first year of PCV7 implementation. Emerg Microbes Infect 3:e39.
    OpenUrl
    1. Ho PL,
    2. Chiu SS,
    3. Ang I,
    4. Lau YL
    (2011) Serotypes and antimicrobial susceptibilities of invasive Streptococcus pneumoniae before and after introduction of 7-valent pneumococcal conjugate vaccine, Hong Kong 1995-2009. Vaccine 29:3270–3275.
    OpenUrlCrossRefPubMedWeb of Science
  26. ↵
    1. Harboe ZB,
    2. Valentiner-Branth P,
    3. Ingels H,
    4. Rasmussen JN,
    5. Andersen PH,
    6. Bjerre CC,
    7. et al.
    (2013) Pediatric invasive pneumococcal disease caused by vaccine serotypes following the introduction of conjugate vaccination in Denmark. PLoS One 8:e51460.
    OpenUrlCrossRefPubMed
  27. ↵
    1. Mendes RE,
    2. Hollingsworth RC,
    3. Costello A,
    4. Jones RN,
    5. Isturiz RE,
    6. Hewlett D Jr.,
    7. et al.
    (2015) Noninvasive Streptococcus pneumoniae serotypes recovered from hospitalized adult patients in the United States in 2009 to 2012. Antimicrob Agents Chemother 59:5595–5601.
    OpenUrlAbstract/FREE Full Text
  28. ↵
    1. De Serres G,
    2. Pilishvili T,
    3. Link-Gelles R,
    4. Reingold A,
    5. Gershman K,
    6. Petit S,
    7. et al.
    (2012) Use of surveillance data to estimate the effectiveness of the 7-valent conjugate pneumococcal vaccine in children less than 5 years of age over a 9 year period. Vaccine 30:4067–4072.
    OpenUrlCrossRefPubMed
  29. ↵
    1. Ochoa-Gondar O,
    2. Gómez-Bertomeu F,
    3. Vila-Córcoles A,
    4. Raga X,
    5. Aguirre C,
    6. Utrera J,
    7. et al.
    (2015) [Prevalence of serotypes causing invasive pneumococcal disease in the region of Tarragona, Spain 2006-2009: vaccine-serotype coverage for the distinct antipneumococcal vaccine formulations]. Rev Esp Quimioter 28:29–35, Spanish.
    OpenUrl
  30. ↵
    1. Pilishvili T,
    2. Lexau C,
    3. Farley MM,
    4. Hadler J,
    5. Harrison LH,
    6. Bennett NM,
    7. et al.
    (2010) Sustained reductions in invasive pneumococcal disease in the era of conjugate vaccine. J Infect Dis 201:32–41, J Infect Dis 2010; 201: 32-41.
    OpenUrlCrossRefPubMedWeb of Science
  31. ↵
    1. Rodrigo C,
    2. Bewick T,
    3. Sheppard C,
    4. Greenwood S,
    5. Macgregor V,
    6. Trotter C,
    7. et al.
    (2014) Pneumococcal serotypes in adult non-invasive and invasive pneumonia in relation to child contact and child vaccination status. Thorax 69:168–173.
    OpenUrlAbstract/FREE Full Text
  32. ↵
    1. Pfaller MA,
    2. Farrell DJ,
    3. Sader HS,
    4. Jones RN
    (2012) AWARE Ceftaroline Surveillance Program (2008-2010): trends in resistance patterns among Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis in the United States. Clin Infect Dis 55(Suppl 3), S187, S193.
  33. ↵
    1. Donkor ES,
    2. Adegbola RA,
    3. Wren BW,
    4. Antonio M
    (2013) Population biology of Streptococcus pneumoniae in West Africa: multilocus sequence typing of serotypes that exhibit different predisposition to invasive disease and carriage. PLoS One 8:e53925.
    OpenUrlCrossRefPubMed
  34. ↵
    1. Siripongpreeda N,
    2. Hattasingh W,
    3. Amornvipas P,
    4. Eampokalap B,
    5. Sakoolgnam S,
    6. Pancharoen C,
    7. et al.
    (2010) Frequency and clinical course of invasive pneumococcal disease caused by penicillin-resistant and penicillin-sensitive Streptococcus pneumoniae in Thai children. J Med Assoc Thai 93(Suppl 5):S1–S5.
    OpenUrl
    1. Shah AS,
    2. Knoll MD,
    3. Sharma PR,
    4. Moisi JC,
    5. Kulkarni P,
    6. Lalitha MK,
    7. et al.
    (2009) Invasive pneumococcal disease in Kanti Children’s Hospital, Nepal, as observed by the South Asian Pneumococcal Alliance network. Clin Infect Dis 48(Suppl 2):S123–S128.
    OpenUrlCrossRefPubMed
  35. ↵
    1. Phongsamart W,
    2. Srifeungfung S,
    3. Chatsuwan T,
    4. Nunthapisud P,
    5. Treerauthaweeraphong V,
    6. Rungnobhakhun P,
    7. et al.
    (2014) Changing trends in serotype distribution and antimicrobial susceptibility of Streptococcus pneumoniae causing invasive diseases in Central Thailand 2009-2012. Hum Vaccin Immunother 10:1866–1873.
    OpenUrl
  36. ↵
    1. Godfroid F,
    2. Hermand P,
    3. Verlant V,
    4. Denoël P,
    5. Poolman JT
    (2011) Preclinical evaluation of the Pht proteins as potential cross-protective pneumococcal vaccine antigens. Infect Immun 79:238–245.
    OpenUrlAbstract/FREE Full Text
  37. ↵
    1. Min X,
    2. Zhang X,
    3. Wang H,
    4. Gong Y,
    5. Li M,
    6. Xu W,
    7. et al.
    (2012) Protection against pneumococcal infection elicited by immunization with glutamyl tRNA synthetase, polyamine transport protein D and sortase A. Vaccine 30:3624–3633.
    OpenUrlPubMed
    1. Harfouche C,
    2. Filippini S,
    3. Gianfaldoni C,
    4. Ruggiero P,
    5. Moschioni M,
    6. Maccari S,
    7. et al.
    (2012) RrgB321, a fusion protein of the three variants of the pneumococcal pilus backbone RrgB, is protective in vivo and elicits opsonic antibodies. Infect Immun 80:451–460.
    OpenUrlAbstract/FREE Full Text
  38. ↵
    1. Liu Y,
    2. Wang H,
    3. Zhang S,
    4. Zeng L,
    5. Xu X,
    6. Wu K,
    7. et al.
    (2014) Mucosal immunization with recombinant fusion protein DnaJ-DeltaA146Ply enhances cross-protective immunity against Streptococcus pneumoniae infection in mice via interleukin 17A. Infect Immun 82:1666–1675.
    OpenUrlAbstract/FREE Full Text
  39. ↵
    1. Xu JH,
    2. Dai WJ,
    3. Chen B,
    4. Fan XY
    (2015) Mucosal immunization with PsaA protein, using chitosan as a delivery system, increases protection against acute otitis media and invasive infection by Streptococcus pneumoniae. Scand J Immunol 81:177–185.
    OpenUrlCrossRef
  40. ↵
    1. Ricketson LJ,
    2. Wood ML,
    3. Vanderkooi OG,
    4. MacDonald JC,
    5. Martin IE,
    6. Demczuk WH,
    7. et al.
    (2014) Trends in asymptomatic nasopharyngeal colonization with Streptococcus pneumoniae after introduction of the 13-valent pneumococcal conjugate vaccine in Calgary, Canada. Pediatr Infect Dis J 33:724–730.
    OpenUrl
  41. ↵
    1. Kumar KL,
    2. Ashok V,
    3. Ganaie F,
    4. Ramesh AC
    (2014) Nasopharyngeal carriage, antibiogram and serotype distribution of Streptococcus pneumoniae among healthy under five children. Indian J Med Res 140:216–220.
    OpenUrlPubMed
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Molecular epidemiology of pneumococcal isolates from children in China
Li-Hua Kang, Meng-Juan Liu, Wen-Chun Xu, Jing-Jing Cui, Xue-Mei Zhang, Kai-Feng Wu, Qun Zhang
Saudi Medical Journal Apr 2016, 37 (4) 403-413; DOI: 10.15537/smj.2016.4.14507

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Molecular epidemiology of pneumococcal isolates from children in China
Li-Hua Kang, Meng-Juan Liu, Wen-Chun Xu, Jing-Jing Cui, Xue-Mei Zhang, Kai-Feng Wu, Qun Zhang
Saudi Medical Journal Apr 2016, 37 (4) 403-413; DOI: 10.15537/smj.2016.4.14507
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