Research ArticleOriginal Article
Open Access

Molecular subtypes of breast carcinoma in Saudi Arabia

A retrospective study

Norah A. Alnegheimish, Razan A. Alshatwi, Reem M. Alhefdhi, Maha M. Arafah, Ammar C. AlRikabi and Sufia Husain
Saudi Medical Journal May 2016, 37 (5) 506-512; DOI: https://doi.org/10.15537/smj.2016.5.15000

References

  1. ↵
    1. Ferlay J,
    2. Soerjomataram I,
    3. Dikshit R,
    4. Eser S,
    5. Mathers C,
    6. Rebelo M,
    7. et al.
    (2015) Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012: Globocan 2012. Int J Cancer 136:E359–E386.
    OpenUrlCrossRefPubMedWeb of Science
  2. ↵
    1. National Cancer Institute
    SEER Cancer Statistics Review 1975-2005, Available from: http://seer.cancer.gov/archive/csr/1975_2005/. Cited 2015 May 2.
  3. ↵
    1. Saudi Cancer Registry
    (2014) Cancer Incidence Report, Saudi Arabia 2010 (Saudi Cancer Registry, Riyadh (KSA)), p 36.
  4. ↵
    1. Al-Rikabi A,
    2. Husain S
    (2012) Increasing prevalence of breast cancer among Saudi patients attending a tertiary referral hospital: a retrospective epidemiologic study. Croat Med J 53:239–243.
    OpenUrlPubMed
  5. ↵
    1. Ezzat AA,
    2. Ibrahim EM,
    3. Raja MA,
    4. Al-Sobhi S,
    5. Rostom A,
    6. Stuart RK
    (1999) Locally advanced breast cancer in Saudi Arabia: high frequency of stage III in a young population. Med Oncol 16:95–103.
    OpenUrlPubMed
  6. ↵
    1. Carey LA,
    2. Dees EC,
    3. Sawyer L,
    4. Gatti L,
    5. Moore DT,
    6. Collichio F,
    7. et al.
    (2007) The triple negative paradox: primary tumor chemosensitivity of breast cancer subtypes. Clin Cancer Res 13:2329–2334.
    OpenUrlAbstract/FREE Full Text
  7. ↵
    1. Sorlie T,
    2. Tibshirani R,
    3. Parker J,
    4. Hastie T,
    5. Marron JS,
    6. Nobel A,
    7. et al.
    (2003) Repeated observation of breast tumor subtypes in independent gene expression data sets. Proc Natl Acad Sci U S A 100:8418–8423.
    OpenUrlAbstract/FREE Full Text
  8. ↵
    1. Viale G
    (2012) The current state of breast cancer classification. Ann Oncol 23(Suppl 10):x207–x210.
    OpenUrlCrossRefPubMed
  9. ↵
    1. Kumar V,
    2. Abbas AK,
    3. Aster JC,
    4. Robbins SL
    (2013) Robbins basic pathology (Elsevier, Saunders, Philadelphia (PA)), 9th ed, pp 708–710.
  10. ↵
    1. Goldhirsch A,
    2. Wood WC,
    3. Coates AS,
    4. Gelber RD,
    5. Thürlimann B,
    6. Senn H-J,
    7. et al.
    (2011) Strategies for subtypes--dealing with the diversity of breast cancer: highlights of the St. Gallen International Expert Consensus on the primary therapy of early breast cancer 2011. Ann Oncol 22:1736–1747.
    OpenUrlCrossRefPubMedWeb of Science
  11. ↵
    1. Andre F,
    2. Pusztai L
    (2006) Molecular classification of breast cancer: implications for selection of adjuvant chemotherapy. Nat Clin Pract Oncol 3:621–632.
    OpenUrlCrossRefPubMedWeb of Science
  12. ↵
    1. Shawarby M,
    2. Al-Tamimi D,
    3. Ahmed A
    (2013) Molecular classification of breast cancer: An overview with emphasis on ethnic variations and future perspectives. Saudi Journal of Medicine and Medical Sciences 1:14.
    OpenUrl
  13. ↵
    1. Kurian AW,
    2. Fish K,
    3. Shema SJ,
    4. Clarke CA
    (2010) Lifetime risks of specific breast cancer subtypes among women in four racial/ethnic groups. Breast Cancer Res 12:R99.
    OpenUrlCrossRefPubMed
  14. ↵
    1. Kwan ML,
    2. Kushi LH,
    3. Weltzien E,
    4. Maring B,
    5. Kutner SE,
    6. Fulton RS,
    7. et al.
    (2009) Epidemiology of breast cancer subtypes in two prospective cohort studies of breast cancer survivors. Breast Cancer Res 11:R31.
    OpenUrlCrossRefPubMed
  15. ↵
    1. Stead LA,
    2. Lash TL,
    3. Sobieraj JE,
    4. Chi DD,
    5. Westrup JL,
    6. Charlot M,
    7. et al.
    (2009) Triple-negative breast cancers are increased in black women regardless of age or body mass index. Breast Cancer Res 11:R18.
    OpenUrlCrossRefPubMed
  16. ↵
    1. Mehdi I,
    2. Monem AA,
    3. Al Bahrani B,
    4. Ramadhan FA
    (2014) Breast cancer molecular subtypes in oman: correlation with age, histology, and stage distribution-analysis of 542 cases. Gulf J Oncolog 1:38–48.
    OpenUrl
  17. ↵
    1. Fourati A,
    2. Boussen H,
    3. El May MV,
    4. Goucha A,
    5. Dabbabi B,
    6. Gamoudi A,
    7. et al.
    (2014) Descriptive analysis of molecular subtypes in Tunisian breast cancer. Asia Pac J Clin Oncol 10:e69–e74.
    OpenUrl
  18. ↵
    1. Tamimi DMA,
    2. Shawarby MA,
    3. Ahmed A,
    4. Hassan AK,
    5. AlOdaini AA
    (2010) Protein expression profile and prevalence pattern of the molecular classes of breast cancer - a Saudi population based study. BMC Cancer 10:223.
    OpenUrlCrossRefPubMed
  19. ↵
    1. Carey LA,
    2. Perou CM,
    3. Livasy CA,
    4. Dressler LG,
    5. Cowan D,
    6. Conway K,
    7. et al.
    (2006) Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study. JAMA 295:2492–2502.
    OpenUrlCrossRefPubMedWeb of Science
  20. ↵
    1. Engstrøm MJ,
    2. Opdahl S,
    3. Hagen AI,
    4. Romundstad PR,
    5. Akslen LA,
    6. Haugen OA,
    7. et al.
    (2013) Molecular subtypes, histopathological grade and survival in a historic cohort of breast cancer patients. Breast Cancer Res Treat 140:463–473.
    OpenUrlCrossRefPubMedWeb of Science
  21. ↵
    1. Lester SC,
    2. Bose S,
    3. Chen Y-Y,
    4. Connolly JL,
    5. de Baca ME,
    6. Fitzgibbons PL,
    7. et al.
    (2009) Protocol for the Examination of Specimens From Patients With Invasive Carcinoma of the Breast. Arch Pathol Lab Med 133:1515–1538.
    OpenUrlPubMed
  22. ↵
    1. Yang XR,
    2. Sherman ME,
    3. Rimm DL,
    4. Lissowska J,
    5. Brinton LA,
    6. Peplonska B,
    7. et al.
    (2007) Differences in risk factors for breast cancer molecular subtypes in a population-based study. Cancer Epidemiol Biomarkers Prev 16:439–443.
    OpenUrlAbstract/FREE Full Text
  23. ↵
    1. Elesawy BH,
    2. Abd El Hafez A,
    3. Shawky AE,
    4. Arafa M
    (2014) Immunohistochemistry-based subtyping of breast carcinoma in Egyptian women: a clinicopathologic study on 125 patients. Ann Diagn Pathol 18:21–26.
    OpenUrl
  24. ↵
    1. Rao C,
    2. Shetty J,
    3. Prasad KH
    (2013) Immunohistochemical profile and morphology in triple - negative breast cancers. J Clin Diagn Res 7:1361–1365.
    OpenUrl
  25. ↵
    1. Cheng H,
    2. Huang T,
    3. Wang W,
    4. Yue J,
    5. Shen N,
    6. Guo H,
    7. et al.
    (2013) Clinicopathological features of breast cancer with different molecular subtypes in Chinese women. J Huazhong Univ Sci Technolog Med Sci 33:117–121.
    OpenUrl
  26. ↵
    1. Dent R,
    2. Trudeau M,
    3. Pritchard KI,
    4. Hanna WM,
    5. Kahn HK,
    6. Sawka CA,
    7. et al.
    (2007) Triple-Negative Breast Cancer: Clinical Features and Patterns of Recurrence. Clin Cancer Res 13:4429–4434.
    OpenUrlAbstract/FREE Full Text
  27. ↵
    1. Kadivar M,
    2. Mafi N,
    3. Joulaee A,
    4. Shamshiri A,
    5. Hosseini N
    (2012) Breast cancer molecular subtypes and associations with clinicopathological characteristics in Iranian women 2002-2011. Asian Pac J Cancer Prev 13:1881–1886.
    OpenUrlPubMed
  28. ↵
    1. Wiechmann L,
    2. Sampson M,
    3. Stempel M,
    4. Jacks LM,
    5. Patil SM,
    6. King T,
    7. et al.
    (2009) Presenting features of breast cancer differ by molecular subtype. Ann Surg Oncol 16:2705–2710.
    OpenUrlCrossRefPubMed
  29. ↵
    1. Cheang MCU,
    2. Voduc D,
    3. Bajdik C,
    4. Leung S,
    5. McKinney S,
    6. Chia SK,
    7. et al.
    (2008) Basal-like breast cancer defined by five biomarkers has superior prognostic value than triple-negative phenotype. Clin Cancer Res 14:1368–1376.
    OpenUrlAbstract/FREE Full Text
  30. ↵
    1. Zaha DC,
    2. Lazăr E,
    3. Lăzureanu C
    (2010) Clinicopathologic features and five years survival analysis in molecular subtypes of breast cancer. Rom J Morphol Embryol 51:85–89.
    OpenUrlPubMed
  31. ↵
    1. Sihto H,
    2. Lundin J,
    3. Lehtimäki T,
    4. Sarlomo-Rikala M,
    5. Bützow R,
    6. Holli K,
    7. et al.
    (2008) Molecular subtypes of breast cancers detected in mammography screening and outside of screening. Clin Cancer Res 14:4103–4110.
    OpenUrlAbstract/FREE Full Text
  32. ↵
    1. Al-Tamimi DM,
    2. Bernard PS,
    3. Shawarby MA,
    4. Al-Amri AM,
    5. Hadi MA
    (2009) Distribution of molecular breast cancer subtypes in middle eastern-saudi arabian women: a pilot study. Ultrastruct Pathol 33:141–150.
    OpenUrlCrossRefPubMed
    1. Vallejos CS,
    2. Gómez HL,
    3. Cruz WR,
    4. Pinto JA,
    5. Dyer RR,
    6. Velarde R,
    7. et al.
    (2010) Breast cancer classification according to immunohistochemistry markers: subtypes and association with clinicopathologic variables in a peruvian hospital database. Clin Breast Cancer 10:294–300.
    OpenUrlPubMed
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